Aspects of Cell Regulation

Contributors

Preface

Supplements in Series

Cellular Factors Which Modulate Hormone Responses: Glucocorticoid Action in Perspective

I. Introduction

II. Cell Entry

III. Steroid-Receptor Interaction

IV. Receptor Activation and Nuclear Translocation

V. Nuclear Binding Sites of the Steroid-Receptor Complex

VI. Mechanism of Gene Activation

VII. Summary

References

Regulation of Genetic Activity by Thyroid Hormones

I. Introduction

II. Thyroid Hormones Participate in Cell Differentiation via Regulation of Nucleic Acid and Protein Syntheses

III. Binding of Thyroid Hormones to the Nuclear Receptor

IV. Binding of Thyroid Hormones to the Cytoplasmic Receptor

V. Binding of Thyroid Hormones to Other Intracellular Components

VI. Major Working Hypothesis on the Mechanisms of Genetic Activity Regulation by Thyroid Hormones

VII. Properties of the Thyroxine Cytoplasmic Receptor

VIII. The Role of the Thyroxine Cytoplasmic Receptor in Translocation of the Hormone from the Nucleus and Acceptance by Chromatin

IX. The Cytoplasmic Receptor as Mediator for the Action of Thyroid Hormones in the Nucleus

X. Interaction of the Hormone-Receptor Complex with DNA

XI. The TBPA-like Cytosol Receptor is a Universal Intracellular Receptor of Thyroid Hormones

References

The Partitioning of Cytoplasmic Organelles at Cell Division

I. Introduction

II. A Note on Terminology: Segregation and Partitioning

III. Numerical Partitioning of Organelles

IV. Compensating Replication

V. Numerical Partitioning of Organelle DNA

VI. Genetic Partitioning of Organelles

VII. Summary

References

Cell Cycle Mutants

I. Introduction

II. Cell Cycle Concept

III. Cell Cycle Mutants

IV. Future Considerations

V. Conclusions

References

Formation of Glyoxysomes

I. Introduction

II. Characterization of Glyoxysomes

III. Origin of Glyoxysomal Components

IV. General Conclusions

References

Mitochondria, Cell Surface, and Carcinogenesis

I. Introduction

II. The Mitochondrial System

III. Tumor Mitochondria

IV. Antimitochondrial Activity of Carcinogens

V. Mitochondria and Cell Surface Characteristics

VI. Mitochondria and Intracellular Systems

VII. Mechanism of Mitochondrial Control

VIII. Conclusions and Prospects

References

Transforming Genes of Tumor Cells

I. Demonstration of Altered DNA in Nonvirally Transformed Cells

II. Transforming DNA of Tumors Induced by Slowly Oncogenic Viruses

III. The Discrete Nature of These Transforming Sequences

IV. The Discovery of Tissue-Specific Oncogenes

V. Isolation of Active Oncogenes

VI. The Relationship of These Tumors to Other Known Oncogenes

VII. Additional Roles of one Genes

VIII. Perspectives

References

Viral Carcinogenesis

I. Introduction

II. Oncogenic DNA Viruses

III. Retroviruses

References

The Origin of Viruses from Cells

I. Introduction

II. Historical

III. Mechanisms for Change in Viruses

IV. The Evolutionary Age of Viruses

V. The Kinds of Cells

VI. The Kinds of Viruses

VII. Chlamydiae and Viruses Compared

VIII. Would a Cell → Virus Transition Be Possible?

IX. Origin of Viruses from Cellular Genetic Elements

X. Conclusions

References

Index