Aspects of Cell Regulation

Aspects of Cell Regulation

1st Edition - March 28, 1983

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  • Editors: G. H. Bourne, J. F. Danielli
  • eBook ISBN: 9781483266664

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Aspects of Cell Regulation deals with the various aspects of cellular control mechanisms. The book begins with a discussion of the role of hormones in the control of cell differentiation and biochemical control over the life of an organism. This is followed by separate chapters on an intracellular control problem, namely, the proper reproduction of cellular organelles and their apportionment between daughter cells at cell mitosis; cell mutants with different temporal order for macromolecular synthesis; and the control of a plant enzyme that converts triglycerides into carbohydrate during the early stages of postgerminative growth within seed cotyledon. Subsequent chapters deal with the possible role of mitochondria in changing the control mechanism of cells to that associated with carcinogenesis; the possibility of transforming genes being detectable in the genome after the transformation to neoplastic cell; the correlation between viruses and tumor cells; and whether viruses can originate from cells rather than coming before cells.

Table of Contents

  • Contributors


    Supplements in Series

    Cellular Factors Which Modulate Hormone Responses: Glucocorticoid Action in Perspective

    I. Introduction

    II. Cell Entry

    III. Steroid-Receptor Interaction

    IV. Receptor Activation and Nuclear Translocation

    V. Nuclear Binding Sites of the Steroid-Receptor Complex

    VI. Mechanism of Gene Activation

    VII. Summary


    Regulation of Genetic Activity by Thyroid Hormones

    I. Introduction

    II. Thyroid Hormones Participate in Cell Differentiation via Regulation of Nucleic Acid and Protein Syntheses

    III. Binding of Thyroid Hormones to the Nuclear Receptor

    IV. Binding of Thyroid Hormones to the Cytoplasmic Receptor

    V. Binding of Thyroid Hormones to Other Intracellular Components

    VI. Major Working Hypothesis on the Mechanisms of Genetic Activity Regulation by Thyroid Hormones

    VII. Properties of the Thyroxine Cytoplasmic Receptor

    VIII. The Role of the Thyroxine Cytoplasmic Receptor in Translocation of the Hormone from the Nucleus and Acceptance by Chromatin

    IX. The Cytoplasmic Receptor as Mediator for the Action of Thyroid Hormones in the Nucleus

    X. Interaction of the Hormone-Receptor Complex with DNA

    XI. The TBPA-like Cytosol Receptor is a Universal Intracellular Receptor of Thyroid Hormones


    The Partitioning of Cytoplasmic Organelles at Cell Division

    I. Introduction

    II. A Note on Terminology: Segregation and Partitioning

    III. Numerical Partitioning of Organelles

    IV. Compensating Replication

    V. Numerical Partitioning of Organelle DNA

    VI. Genetic Partitioning of Organelles

    VII. Summary


    Cell Cycle Mutants

    I. Introduction

    II. Cell Cycle Concept

    III. Cell Cycle Mutants

    IV. Future Considerations

    V. Conclusions


    Formation of Glyoxysomes

    I. Introduction

    II. Characterization of Glyoxysomes

    III. Origin of Glyoxysomal Components

    IV. General Conclusions


    Mitochondria, Cell Surface, and Carcinogenesis

    I. Introduction

    II. The Mitochondrial System

    III. Tumor Mitochondria

    IV. Antimitochondrial Activity of Carcinogens

    V. Mitochondria and Cell Surface Characteristics

    VI. Mitochondria and Intracellular Systems

    VII. Mechanism of Mitochondrial Control

    VIII. Conclusions and Prospects


    Transforming Genes of Tumor Cells

    I. Demonstration of Altered DNA in Nonvirally Transformed Cells

    II. Transforming DNA of Tumors Induced by Slowly Oncogenic Viruses

    III. The Discrete Nature of These Transforming Sequences

    IV. The Discovery of Tissue-Specific Oncogenes

    V. Isolation of Active Oncogenes

    VI. The Relationship of These Tumors to Other Known Oncogenes

    VII. Additional Roles of one Genes

    VIII. Perspectives


    Viral Carcinogenesis

    I. Introduction

    II. Oncogenic DNA Viruses

    III. Retroviruses


    The Origin of Viruses from Cells

    I. Introduction

    II. Historical

    III. Mechanisms for Change in Viruses

    IV. The Evolutionary Age of Viruses

    V. The Kinds of Cells

    VI. The Kinds of Viruses

    VII. Chlamydiae and Viruses Compared

    VIII. Would a Cell → Virus Transition Be Possible?

    IX. Origin of Viruses from Cellular Genetic Elements

    X. Conclusions



Product details

  • No. of pages: 298
  • Language: English
  • Copyright: © Academic Press 1983
  • Published: March 28, 1983
  • Imprint: Academic Press
  • eBook ISBN: 9781483266664

About the Editors

G. H. Bourne

Affiliations and Expertise

Department of Anatomy, Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia

J. F. Danielli

Affiliations and Expertise

Department of Biochemical Pharmacology,School of Pharmacy,State University of New York at Buffalo,Buffalo, New York

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