Holcomb and Ashcraft's Pediatric Surgery

Holcomb and Ashcraft's Pediatric Surgery

7th Edition - April 14, 2019

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  • Authors: George Holcomb, J. Patrick Murphy, Shawn St Peter
  • Hardcover ISBN: 9780323549400
  • eBook ISBN: 9780323549769

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Description

Known for its readability, portability, and global perspectives, Holcomb and Ashcraft’s Pediatric Surgery remains the most comprehensive, up-to-date, single-volume text in its field. As technology and techniques continue to evolve, the 7th Edition provides state-of-the-art coverage—both in print and on video—of the full range of general surgical and urological problems in infants, children, and adolescents, equipping you to achieve optimal outcomes for every patient.

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Preface
  • List of Contributors
  • Dedication
  • Section I. General
  • 1. Physiology of the Newborn
  • Specific Physiologic Problems of the Newborn
  • Fluids and Electrolytes
  • Cardiovascular System of the Newborn
  • Monitoring
  • Shock
  • 2. Nutritional Support for the Pediatric Patient
  • The Metabolic Response to Stress
  • Body Composition and Nutrient Reserves
  • Energy Expenditure During Illness
  • Macronutrient Intake
  • Routes of Nutritional Provision
  • Conclusion
  • 3. Anesthetic Considerations for Pediatric Surgical Conditions
  • Risks of Anesthesia
  • Preoperative Anesthesia Evaluation
  • Clinical Scenarios and High-Risk Populations
  • Intraoperative Management
  • Postanesthesia Care
  • Discharge Criteria
  • Conclusion
  • 4. Renal Impairment and Renovascular Hypertension
  • Body Fluids and Electrolyte Regulation
  • Renal Function Evaluation
  • Acute Kidney Injury
  • Acute Kidney Injury in the Neonate
  • Obstructive Uropathy in the Neonate
  • Renovascular Hypertension
  • 5. Coagulopathies and Sickle Cell Disease
  • Clinical Evaluation
  • Laboratory Evaluation
  • Hemophilia A and B
  • Clotting Factor Dosing
  • Neonatal Hemostasis
  • Disseminated Intravascular Coagulation
  • Management of Quantitative and Qualitative Platelet Disorders
  • Disorders of Thrombin Generation and Fibrin Formation
  • Fibrinolytic and Thrombotic Disorders
  • Recombinant Activated Factor VII
  • Sickle Cell Disease
  • 6. Extracorporeal Membrane Oxygenation
  • History
  • Clinical Applications
  • Patient Selection Criteria
  • Indications for ECMO
  • Unique Indications for ECMO
  • Methods of Extracorporeal Support
  • Patient Management on ECMO
  • Complications
  • Outcomes
  • Long-Term Sequelae
  • Advances and Areas of Research
  • 7. Mechanical Ventilation in Pediatric Surgical Disease
  • Physiology of Gas Exchange During Mechanical Ventilation
  • Nonconventional Modes and Adjuncts to Mechanical Ventilation
  • Ventilator-Associated Pneumonia
  • 8. Vascular Access
  • Peripheral Venous Access
  • Umbilical Vein and Artery Access
  • Peripherally Introduced Central Catheter
  • Central Venous Catheters
  • Totally Implanted Central Venous Catheters
  • Intraosseous Access
  • Venous Cutdown
  • Alternative Routes for Central Venous Access
  • Arterial Catheter
  • Hemodialysis Catheters
  • 9. Surgical Infectious Disease
  • Pathogenesis of Infection
  • Defense Against Infection
  • Antibiotics
  • Prevention of Infections
  • Types of Infection
  • 10. Fetal Therapy
  • Guiding Principles
  • Fetal Access, Anesthesia, and Operative Setup
  • Anomalies Amenable to Fetal Surgery
  • Stem Cells and Gene Therapy
  • Fetal Surgery Programs
  • The Future
  • Section II. Trauma
  • 11. Ingestion of Foreign Bodies
  • Esophageal Foreign Bodies
  • Gastrointestinal Foreign Bodies
  • Special Topic Ingestions
  • Airway Foreign Bodies
  • 12. Bites
  • Bites
  • Tetanus
  • Rabies and Postexposure Prophylaxis
  • Spider Bites
  • Snake Bites
  • 13. Burns
  • Pathophysiology
  • Initial Management
  • Fluid Resuscitation
  • Inhalation Injury
  • Assessment of Burn Depth
  • Wound Care
  • Nonthermal Injuries
  • Toxic Epidermal Necrolysis and Stevens–Johnson Syndrome
  • Psychologic Sequelae of Burn Injuries
  • Multidisciplinary Care
  • 14. Early Assessment and Management of Trauma
  • Injury Epidemiology
  • Injury Risks
  • Injury Outcomes
  • Injury Prevention
  • Injury Patterns
  • Prehospital Care
  • Emergency Care
  • Special Considerations in Trauma Care
  • The Regional Pediatric Trauma System
  • 15. Thoracic Trauma
  • Anatomy and Physiology
  • Specific Injuries and Management
  • 16. Abdominal and Renal Trauma
  • Resuscitation of the Child With Blunt Abdominal Trauma
  • Evaluation of Blunt Abdominal Trauma
  • Liver and Spleen Injury Management
  • Renal Injury
  • Pancreatic Injury
  • Blunt Intestinal Injury
  • Blunt Abdominal Aortic Trauma
  • Blunt Diaphragmatic Injury
  • Laparoscopy In Trauma
  • Complications
  • Follow-Up Care
  • 17. Traumatic Brain Injury
  • Epidemiology and Anatomy
  • Brain Injury Mechanisms
  • Pathophysiology
  • Initial Evaluation FOR TBI
  • Outcome and Prognosis
  • 18. Pediatric Orthopedic Trauma
  • Pathophysiology
  • Complex Injuries
  • Fractures of the Lower Extremity
  • Spine Injuries
  • Fractures of the Upper Extremity
  • 19. Neurosurgical Conditions
  • Hydrocephalus
  • Neurosurgical Devices
  • Skull Masses
  • Neural Tube Defects
  • Craniosynostosis
  • Vascular Malformations of the Brain
  • Tethered Spinal Cord
  • Chiari I Malformations
  • Brain Tumors
  • Intracranial Infections
  • Section III. Thoracic
  • 20. Chest Wall Deformities
  • Pectus Excavatum
  • Pectus Carinatum
  • Poland Syndrome
  • Sternal Defects
  • Thoracic Insufficiency Syndrome Associated With Diffuse Skeletal Disorders
  • 21. Management of Laryngotracheal Obstruction in Children
  • Embryology and Anatomy
  • Subglottic and Tracheal Malformations
  • Tracheomalacia–Bronchomalacia
  • Inflammatory Obstructions
  • Airway Injuries
  • Laryngeal and Tracheal Clefts
  • Tracheal Repair
  • Tracheal Agenesis
  • 22. Congenital Bronchopulmonary Malformations
  • Embryology and Development of the Bronchopulmonary Tree
  • Prenatal Diagnosis and Classification of Congenital Bronchopulmonary Malformations
  • Prenatal and Perinatal Management of Bronchopulmonary Malformations
  • Postnatal Management of Bronchopulmonary Malformations
  • Thoracoscopic Lobectomy
  • 23. Acquired Lesions of the Lung and Pleura
  • Parapneumonic Effusions
  • Lung Abscess
  • Pneumatocele
  • Bronchiectasis
  • Chylothorax
  • Diffuse Interstitial Disease
  • Right Middle Lobe Syndrome
  • Spontaneous Pneumothorax
  • 24. Congenital Diaphragmatic Hernia and Eventration
  • Epidemiology
  • Genetics
  • Associated Anomalies
  • Cost
  • Embryology
  • Diagnosis
  • Treatment
  • Operative Repair
  • Anterior Hernias of Morgagni
  • Diaphragmatic Eventration
  • 25. Mediastinal Tumors
  • Clinical Features
  • Diagnostic Imaging
  • Principles of Management
  • Lymphoma
  • Germ Cell Tumors
  • Tumors and Cysts of the Thymus
  • Vascular Tumors and Anomalies
  • Foregut Cysts and Duplications
  • Neural Tumors
  • Other Rare Anterior Mediastinal Tumors
  • 26. The Esophagus
  • Surgical Anatomy and Physiology
  • Clinical Evaluation of the Esophagus
  • Congenital Anomalies of the Esophagus
  • Achalasia
  • Foreign Body Esophageal Injury
  • Esophageal Perforation
  • Caustic Ingestion
  • Esophageal Strictures
  • Esophageal Replacement
  • 27. Esophageal Atresia and Tracheoesophageal Fistula Malformations
  • Embryology
  • Epidemiology
  • Associated Anomalies
  • Classification
  • Diagnosis
  • Management
  • Operative Repair
  • Complications From Operative Repair
  • H-Type Fistula
  • Laryngeal and Laryngotracheoesophageal Cleft
  • Section IV. Abdomen
  • 28. Gastroesophageal Reflux
  • Pathophysiology
  • Barriers Against GERD
  • Clinical Manifestations
  • Medical Management of GER
  • Medical Management of GERD
  • Diagnostic Evaluation
  • Operative Management
  • Postoperative Care
  • Outcomes
  • Redo Fundoplication
  • 29. Lesions of the Stomach
  • Hypertrophic Pyloric Stenosis
  • Pyloric Atresia
  • Gastric Perforation
  • Peptic Ulcer Disease
  • Gastric Duplications
  • Microgastria
  • Antral Web
  • Gastric Volvulus
  • Foreign Bodies and Bezoar
  • 30. Duodenal and Intestinal Atresia and Stenosis
  • Duodenal Atresia and Stenosis
  • Jejunoileal Atresia and Stenosis
  • Colonic Atresia
  • 31. Malrotation
  • Embryology
  • Presentation
  • Diagnosis
  • Management
  • Postoperative Management
  • Special Considerations
  • 32. Meconium Disease
  • Meconium Ileus
  • Cystic Fibrosis
  • Simple Meconium Ileus
  • Complicated Meconium Ileus
  • Meconium Plug Syndrome
  • Complications of Meconium Ileus and Cystic Fibrosis
  • Outlook
  • 33. Necrotizing Enterocolitis
  • Epidemiology
  • Pathophysiology
  • Clinical Diagnosis
  • Differential Diagnosis
  • Grading System
  • Medical Management
  • Surgical Management
  • Outcomes
  • Prevention
  • Conclusion
  • 34. Hirschsprung Disease
  • Incidence and Spectrum of Disease
  • Etiology and Genetic Basis of Disease
  • Clinical Presentation and Diagnosis
  • Preoperative Preparation
  • Surgical Management
  • Postoperative Management
  • Long-Term Outcomes
  • Variant Hirschsprung Disease
  • Future Directions
  • 35. Anorectal Atresia and Cloacal Malformations
  • Male Anorectal Defects
  • Female Anorectal Defects
  • Associated Defects
  • Newborn Management
  • Definitive Repair: Male
  • Definitive Repair: Female
  • Postoperative Management
  • Functional Outcomes
  • Evaluation of Results
  • Summary
  • 36. Fecal Incontinence and Constipation
  • Mechanism of Continence
  • True Fecal Incontinence
  • Bowel Management: Key Steps
  • Constipation in Anorectal Malformations and Hirschsprung Disease
  • Functional Constipation
  • 37. Acquired Anorectal Disorders
  • Perianal and Perirectal Abscess
  • Fistula-in-Ano
  • Anal Fissure
  • Anal Skin Tags, Hemorrhoids, Polyps, and Other Perianal Vascular Lesions
  • Rectal Prolapse
  • Rectal Trauma
  • 38. Intussusception
  • Pathophysiology
  • Incidence
  • Clinical Presentation
  • Physical Examination
  • Diagnosis
  • Nonoperative Management
  • Operative Management
  • Recurrent Intussusception
  • Postoperative Intussusception
  • 39. Alimentary Tract Duplications
  • Embryology
  • Clinical Presentation and Diagnosis
  • Classification and Treatment by Location
  • Summary
  • 40. Meckel Diverticulum
  • Epidemiology
  • Clinical Presentation
  • Diagnosis
  • Treatment
  • 41. Inflammatory Bowel Disease
  • Ulcerative Colitis
  • Crohn Disease
  • Indeterminate Colitis
  • Transition to Adulthood
  • 42. Appendicitis
  • Pathophysiology and Natural History
  • Clinical Features
  • Appendicitis Risk Scores
  • Imaging Studies
  • Clinical Pathways
  • Alternative Diagnoses
  • Treatment
  • Nonperforated Appendicitis
  • Perforated Appendicitis
  • Abscess on Presentation
  • 43. Biliary Atresia
  • Incidence
  • Pathogenesis
  • Histopathology
  • Diagnosis
  • Screening
  • Surgical Intervention
  • Postoperative Management
  • Postoperative Complications
  • Results and Prognosis
  • Liver Transplantation
  • 44. Choledochal Cyst and Gallbladder Disease
  • Choledochal Cyst
  • Gallbladder Disease
  • 45. Solid Organ Transplantation in Children
  • Liver Transplantation
  • Intestinal Transplantation
  • Renal Transplantation
  • Metabolic Syndrome and Cardiovascular Disease
  • Pancreas Transplantation
  • 46. Lesions of the Pancreas
  • Congenital Anomalies
  • Pancreatitis
  • Functional Pancreatic Disorders
  • Pancreatic Tumors and Cysts
  • 47. Splenic Conditions
  • Embryology, Anatomy, and Physiology
  • Anatomic Abnormalities
  • Indications for Splenectomy
  • Splenectomy
  • Single-Incision Laparoscopic Surgery and Single-Incision Laparoendoscopic Surgery Splenectomy
  • Partial Splenectomy
  • Complications and Controversies With Laparoscopic Splenectomy
  • 48. Congenital Abdominal Wall Defects: Gastroschisis and Omphalocele
  • Gastroschisis
  • Postnatal Management
  • Omphalocele
  • 49. Umbilical and Other Abdominal Wall Hernias
  • Umbilical Hernia
  • Epigastric Hernia
  • Spigelian Hernia
  • Lumbar Hernia
  • Section V. Inguinal Region and Scrotum
  • 50. Inguinal Hernia
  • Incidence and Epidemiology
  • Embryology
  • Associations and Risk Factors
  • Classification
  • Clinical Findings
  • Operative Technique
  • Inguinal Hernia Repair in Infants
  • Comparison of Open Versus Laparoscopic Repairs
  • Special Circumstances
  • Complications
  • 51. Undescended Testes and Testicular Tumors
  • Undescended Testes
  • Testicular Neoplasms
  • 52. The Acute Scrotum
  • Testicular Torsion
  • Conditions Mimicking Testicular Torsion
  • Section VI. Urology
  • 53. Developmental and Positional Anomalies of the Kidneys
  • Renal Embryology
  • Renal Dysplasia and Hypoplasia
  • Renal Agenesis
  • Supernumerary Kidney
  • Renal Ectopia
  • Fusion Defects
  • Cystic Renal Disease and Cystic Tumors
  • 54. Ureteral Obstruction and Malformations
  • Ureteropelvic Junction Obstruction in Children
  • Surgical Results and Complications
  • Ureteral Abnormalities
  • Ectopic Ureter
  • Ureteroceles
  • 55. Urinary Tract Infections and Vesicoureteral Reflux
  • Urinary Tract Infections
  • Vesicoureteral Reflux
  • 56. Bladder and Urethra
  • Childhood Incontinence
  • Nocturnal Enuresis
  • Daytime Incontinence
  • Neurogenic Bladder
  • Urethral Disorders
  • 57. Posterior Urethral Valves
  • Embryology and Anatomy
  • Antenatal Diagnosis, Management, and Outcomes
  • Clinical Presentation
  • Radiographic Evaluation
  • Initial Management
  • Late Diagnosis
  • Vesicostomy Closure
  • Vesicoureteral Reflux
  • Bladder Dysfunction After Initial Therapy
  • Long-Term Risk of End-Stage Renal Disease
  • Renal Transplantation
  • Adult Sexual Function and Fertility
  • 58. Bladder and Cloacal Exstrophy
  • Bladder Exstrophy
  • Cloacal Exstrophy
  • 59. Hypospadias
  • Embryology
  • Historical Perspective
  • Clinical Aspects
  • Treatment
  • Operative Approaches
  • Technical Perspectives
  • Complications
  • Results
  • 60. Circumcision
  • The Prepuce
  • Medical Indications
  • Routine Circumcision at Birth
  • Surgical Technique
  • Complications
  • 61. Prune Belly Syndrome
  • Genetics
  • Embryology
  • Clinical Features
  • Clinical Presentation
  • Management Principles
  • Surgical Management
  • Conclusion
  • 62. Differences of Sexual Development
  • Normal Gender and Sexual Differentiation
  • Aberrant Genital Development
  • Evaluation of the Newborn With Ambiguous Genitalia
  • Fertility Potential and Preservation
  • Psychosexual Development
  • Reconstructive Genital Surgical Procedures
  • Section VII. Neoplasms
  • 63. Principles of Adjuvant Therapy in Childhood Cancer
  • History of Pediatric Oncology
  • Epidemiology and Survival Statistics for Childhood Cancer
  • Importance of Pathology of Childhood Tumors in Selecting Chemotherapy
  • Tumor Biology: Understanding Childhood Cancer and Treatment Principles
  • Cancer Cytogenetics
  • Chemotherapy Principles in Pediatric Oncology
  • Adjuvant and Neoadjuvant Chemotherapy
  • Chemotherapy Dose Intensity
  • Chemotherapeutic Agents
  • Acute Chemotherapy Toxicity and Supportive Care
  • Biologic Targeted Therapy
  • Local Tumor Control
  • Innovative Adjunctive Techniques
  • 64. Renal Tumors
  • Wilms Tumor
  • Renal Cell Carcinoma
  • Mesoblastic Nephroma
  • Cystic Nephroma
  • Ossifying Renal Tumor of Infancy
  • Angiomyolipomas
  • Renal Medullary Carcinoma
  • 65. Neuroblastoma
  • Pathology
  • Molecular Biology
  • Clinical Presentation
  • Risk-Directed Therapy Based on International Neuroblastoma Staging System
  • International Neuroblastoma Risk Group Risk Stratification
  • Surgery for Neuroblastoma
  • Special Management Situations
  • New Treatment Strategies
  • 66. Lesions of the Liver
  • Benign Hepatic Tumors
  • Malignant Hepatic Tumors
  • New Therapeutic Treatment Options for Liver Tumors
  • 67. Teratomas, Dermoids, and Other Soft Tissue Tumors
  • Teratomas
  • Dermoid, Epidermoid, and Related Cysts
  • Soft Tissue and Nerve Tumors
  • 68. Lymphomas
  • Hodgkin Lymphoma
  • Non-Hodgkin Lymphoma
  • 69. Rhabdomyosarcoma
  • Tumor Biology and Histology
  • Presentation
  • Assessment
  • Staging
  • Treatment
  • Metastatic Disease and Recurrent Rhabdomyosarcoma
  • Outcomes
  • Late Effects
  • Section VIII. Skin and Soft Tissue Diseases
  • 70. Nevus and Melanoma
  • Anatomy of the Dermis and Epidermis
  • Acquired Melanocytic Nevi
  • Congenital Melanocytic Nevi
  • Spitz Nevi
  • Melanoma
  • 71. Vascular Anomalies
  • Nomenclature
  • Classification
  • Vascular Tumors
  • Vascular Malformations
  • Combined Vascular Malformations
  • Interdisciplinary Vascular Anomalies Center
  • 72. Head and Neck Sinuses and Masses
  • Lesions of Embryonic Origin
  • Inflammatory Lesions
  • Section IX. Special Topics
  • 73. Pediatric and Adolescent Gynecology
  • Normal Anatomy
  • Genital Examination
  • Uterovaginal Anomalies
  • Adnexal Disease
  • Stratifying Adnexal Masses
  • Adnexal Torsion
  • Endometriosis
  • Fertility Preservation
  • 74. Breast Diseases
  • Development, Anatomy, and Physiology
  • Pathophysiology
  • Disorders of Development and Growth
  • Inflammatory Lesions
  • Nipple Discharge
  • Breast Masses
  • 75. Endocrine Disorders and Tumors
  • Thyroid Gland
  • Parathyroid Glands
  • Adrenal Glands
  • Precocious Puberty
  • Carcinoid Tumors
  • 76. Bariatric Surgical Procedures in Adolescence
  • Definitions
  • Consequences of Adolescent Obesity
  • Guidelines for Performing Bariatric Surgical Procedures in Adolescents
  • Surgical Options
  • Perioperative and Surgical Management
  • Postoperative Management
  • Long-Term Management
  • Outcomes in Adolescents
  • Summary
  • Index

Product details

  • No. of pages: 1316
  • Language: English
  • Copyright: © Elsevier 2019
  • Published: April 14, 2019
  • Imprint: Elsevier
  • Hardcover ISBN: 9780323549400
  • eBook ISBN: 9780323549769

About the Authors

George Holcomb

Affiliations and Expertise

Katharine Berry Richardson Professor of Surgery, Senior Vice-President, The Children's Mercy Hospital, Kansas City, MO, USA

J. Patrick Murphy

Affiliations and Expertise

Professor of Surgery, Department of Surgery, The Children’s Mercy Hospital, Kansas City, MO, USA

Shawn St Peter

Affiliations and Expertise

Surgeon-in-Chief, Thomas Holder and Keith Ashcraft Endowed Chair; Director, Pediatric Surgery Fellowship; Director, Center for Prospective Trials; Professor of Surgery, The Children’s Mercy Hospital, Kansas City, MO, USA

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