This book tackles a number of different perspectives concerning the parasitic helminth Ascaris, both in animals and in humans and the disease known as ascariasis. It seeks to identify interesting, exciting and novel aspects, which will interest readers from a broad range of disciplines.
Over a quarter of the world's population are infected with the human roundworm, and the equivalent in pigs is equally ubiquitous. Both contribute to insidious and chronic nutritional morbidity, and this has been quantified, in humans, as disability adjusted life years approximating 10.5 million. Ascaris larvae develop in host parenteral tissues, and the resultant pathology has been condemnation. Ascariasis, despite its staggering global prevalence and the sheer numbers of people it infects, remains a classic neglected disease. However, renewed interest in the consequences of early infection with worms from the perspective of immune modulation, co-infections and the development of allergy further enhances the relevance of these parasites.
- Brings together a wide range of topics and approaches and recent, comprehensive and progressive research concerning the neglected parasite Ascaris
- Provides a blueprint of how a single parasite entity can stimulate interest in basic biology, clinical science, veterinary science, public health and epidemiology
- Presents a wealth of new insights given that a book on this parasite has not been published for over 20 years
- 16 chapters from a range of top authors from around the world
Advanced researchers and students in helminthology, parasitology, epidemiology, molecular and immunological biology. Parasitologists and life scientists working on nematode parasites, veterinary surgeons, veterinary parasitologists, clinicians interested in human parasitology and human health, epidemiologists, World Health professionals.
Section I: Biology of Ascaris
1. Immunology of Ascaris and immunomodulation
2. Ascaris and allergy
3. The significance of ABA-1
4. Implications of co-infection with Ascaris
Section II: Model systems
5. The use of the mouse model to explore the role of the liver in susceptibility and resistance to Ascaris
6. Unique attributes of Ascaris as a model system: Neurobiology
Section III: Epidemiology of ascariasis
7. Ascaris lumbricoides: new epidemiological insights and mathematical approaches
8. Genetic epidemiology of Ascaris
9. Mathematical Modeling
Section IV. Host and parasite genetics
10. New insights into evolutionary-history and phylogeography of Ascaris
11. Ascaris genomics
12. Human host susceptibility to ascariasis
Section V. Clinical aspects and public health
13. The extent of the problem: numbers and impact (Ascaris lumbricoides)
14. Impact of Ascaris suum in livestock
15. Approaches to control of STHs including ascariasis
16. Diagnosis and control of Ascaris suum
- No. of pages:
- © Academic Press 2013
- 10th June 2013
- Academic Press
- eBook ISBN:
- Hardcover ISBN:
Professor Celia Holland, BSc, PhD, MRIA is a Professor of Parasitology at Trinity College Dublin and currently Head of School of Natural Sciences, Trinity College. Her main research interests are in the epidemiology and control of the soil-transmitted helminths including Ascaris and Toxocara. She is also involved in the development of laboratory models for larval ascarids and aspects of ecological parasitology including helminth community structure. She was elected to Fellowship of Trinity College and as a member of the Royal Irish Academy, in recognition of her research.
Professor Holland is an Invited Expert on the WHO Advisory Panel on Parasitic Diseases and currently Secretary General of the European Federation of Parasitology. She is an Editor of the journal Parasitology (CUP). She was previously President and Secretary of the Irish Society for Parasitology. Author of over 100 publications including peer-reviewed journal articles, books, and book chapters on parasitology and related topics; including the senior editorship of “Toxocara the enigmatic parasite” and “The Geohelminths: Ascaris, Trichuris and Hookworm” as part of the World Class Parasites series.
"The publication of this book is…very welcome, with its aim to highlight this state of affairs and to stimulate interest in this much neglected parasite…this volume can be highly recommended to all with an interest in parasitic nematode infection and neglected tropical diseases. It is both an excellent summary of the current state of knowledge of Ascaris infection, and a very useful resource for those studying other parasites."--Parasites & Vectors, January 17, 2014
"Ascaris lumbricoides is a parasitic nematode worm that primarily infects children in impoverished conditions throughout the tropics. As many as 1.2 billion people may be infected. It causes both developmental and cognitive problems in the infected. In spite of being such a common affliction Ascaris remains little studied. This volume of essays…attempts to address that."--Reference & Research Book News, December 2013