Asbestos and Disease

Asbestos and Disease

1st Edition - August 28, 1978

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  • Author: Author Unknown
  • eBook ISBN: 9780323140072

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Asbestos and Disease provides a much-needed comprehensive compendium and presentation of accumulated information on asbestos and disease. Organized into five parts, this book begins with the nature, occurrence, properties, mining, milling, manufacturing, and use of asbestos minerals. Some chapters follow on the identification, quantification, and environmental distribution of asbestos fibers. This book also tackles the asbestotic and neoplastic effects of asbestos. The pathogenic mechanisms, prevention, and control of asbestos are also addressed. This work will provide nonspecialists with easily comprehensible and meaningful data that will assist them in their endeavors in this field.

Table of Contents

  • Foreword


    Part I Asbestos and Its Distribution

    1 Historical Background

    Early Beginnings

    The Intermediate Years

    The Breakthrough Period

    Development of Manufacture and Use

    Recognition of Pathogenicity

    Appearance of Other Pathological Consequences

    State of Medical Knowledge in the Early 1960's

    2 Asbestos Minerals: Nature, Occurrence, and Properties

    Geological Formation

    Chemical Characteristics

    Physical Characteristics



    3 Mining, Milling, Manufacturing, and Use




    End Uses

    Disposal of Wastes Containing Asbestos

    4 Identification and Quantitation of Asbestos Fibers

    Basic Considerations in Sampling of Airborne Dust

    Collection of Airborne Dust Samples

    Dust Examination by Light Microscopy

    Dust Examination by Electron Beam Methods

    Constraints on Electron Beam Methods: Ancillary Techniques

    Determination of Asbestos in Tissue

    Examination of Water and Food for Asbestos

    5 Environmental Distribution

    Asbestos in Air

    Asbestos in Water

    Asbestos in Food and Drugs

    Asbestos in Consumer Products

    Part II Asbestotic Effects

    6 Basic Clinical Considerations

    7 Characteristics and Etiology of Parenchymal Asbestosis



    Clinical Characteristics


    8 Characteristics and Etiology of Pleural Asbestosis



    Clinical Characteristics


    9 Prevalence, Diagnosis, and Course of the Asbestoses



    Clinical Course

    Part III Neoplastic Effects

    10 Characteristics and Etiology of Mesothelioma



    Clinical Manifestations


    11 Prevalance, Diagnosis, and Course of Mesothelioma



    Clinical Course

    12 Characteristics, Etiology, and Prevalence of Asbestos-Associated Carcinoma


    Special Features



    Part IV Pathogenic Mechanisms

    13 Respiratory Portal of Entry


    Physiology of Air Flow

    Particle Desposition


    Effects of Disease and of Other Pollutants

    14 The Gastrointestinal Tract and Other Portals of Entry

    Sources of Alimentary Intake

    Physical Situation at the Bowel Wall

    Evidence for Penetration of Gastrointestinal Wall

    Pathogenic Significance of Ingested Asbestos

    Other Portals of Entry

    15 General Tissue Reactions and Cytotoxicity

    Some Problems

    Movement of Fibers

    Hemolytic Properties of Asbestos Fibers

    In Vitro Cytotoxic Effects of Asbestos

    Immunological Reactions

    16 Phagocytosis and the Asbestos Body

    Origin of Phagocytes

    Process of Phagocytosis

    Formation of Asbestos Bodies

    17 Fibrogenesis and Tumorigenesis

    Fibrogenesis from Asbestos

    Tumorigenesis from Asbestos

    Relation of Pathogenesis to Fiber Size

    Part V Prevention and Control

    18 Regulatory Principles and Objectives

    Information Required for Formulation of Criteria

    Status of Information on Asbestos

    19 Examples of National Regulatory Development

    Development of Standards in the United States

    Development of Workplace Standards in Great Britain

    Notes on Action Taken in Other Countries

    20 Procedures for Prevention and Control

    Substitution of Less Hazardous Materials

    Suppression of Dust at Source

    Rapid Removal

    Personal Protection

    Other Action





    Subject Index

Product details

  • No. of pages: 549
  • Language: English
  • Copyright: © Academic Press 1978
  • Published: August 28, 1978
  • Imprint: Academic Press
  • eBook ISBN: 9780323140072

About the Author

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