I: Basic concepts of pulsatile arterial hemodynamics
Principles and definitions of arterial stiffness, wave reflections and pulse pressure amplification. Large arteries, microcirculation and the mechanism of hypertension. Direct measurement of local arterial stiffness and pulse pressure. Determination of systemic and regional arterial stiffness. Interrelations of structure and function of large arteries in epidemiology.
II: Pathophysiological mechanisms
Mechanical stress and the arterial wall. Pulsatile stress, arterial stiffness and endothelial function. Endothelial-dependent vascular modulation by pulse perfusion. Central arterial aging: humans to molecules. Elastin, calcium and the arterial wall. Animal models for studies of arterial stiffness. Renin-angiotensin system, large arteries and micro-circulation. Arterial distensibility and the sympathetic nervous system.
III: Arterial stiffness, wave reflections, cardiovascular risk and end-organ damage
Brachial and central pulse pressure and cardiovascular risk. Large artery stiffness and cardiovascular risk: introduction to risk assessment and new strategies. Small artery elasticity index, endothelial function and cardiovascular risk. Genetic aspects of arterial stiffness and pulse pressure in clinical hypertension. Heart rate, pulse pressure and arterial stiffness. The relation of large arterial structure and function to cardiac hypertrophy in hypertension. Arterial stiffness in chronic heart failure. Arterial stiffness and various cardiovascular diseases . Arterial function in end-stage renal disease. Arterial changes in renal transplantation.Carotid intima-media thickness and arterial stiffness.
IV: Clinical aspects of arterial stiffness and wave reflections
Aging: a physical perspective. Hypertension in women: is it different. Arterial stiffness and wave reflections at the different stages of the hyper