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Arterial Stiffness and Pulsatile Hemodynamics in Health and Disease - 1st Edition - ISBN: 9780128202937

Arterial Stiffness and Pulsatile Hemodynamics in Health and Disease

1st Edition

Editor: Julio Chirinos
Hardcover ISBN: 9780128202937
Imprint: Academic Press
Published Date: 1st October 2021
Page Count: 750
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Arterial Stiffness and Pulsatile Hemodynamics in Health and Disease cover the principles, physiology, biologic pathways, clinical implications and therapeutics surrounding the topic, providing a thorough overview of the field and presenting complex engineering concepts in a way that those in science and medicine can more easily understand. Additionally, advanced bioengineering concepts are presented in boxes for the reader who wants more in-depth biophysical knowledge. This is a must-have reference for students, researchers and clinicians interested in learning more about this field. It includes detailed illustrations, animations and slideshows to assist readers with learning objectives.

Key Features

  • Provides a comprehensive review of the clinical implications of arterial stiffness and pulsatile hemodynamics and its role in human disease
  • Incorporates case studies and calculations/worked examples with mathematical principles explained in a conceptual manner without complicated formulas
  • Features chapter contributions from leading international researchers and clinicians


Researchers, clinicians (cardiologists, hypertension specialists, general internists, nephrologists, neurologists, geriatricians) and bioengineers interested in physiology, arterial stiffness and pulsatile hemodynamics, students and clinicians in life science, genetics and medicine; medical device companies

Table of Contents

Section I. Biophysical and Technical Principles

1. Basic Principles of pulsatile pressure and flow phenomena in elastic vessels

2. Measurements of arterial pressure and flow in vivo

3. Essential Principles of Pulsatile Pressure-flow relations in the arterial tree

4. Magnetic Resonance Imaging for the assessment of aortic stiffness and pulsatile hemodynamics

5. Computed tomography of the aorta

6. Radionuclide-based Imaging of the aortic wall

7. Arterial wall stiffness: basic principles and methods of measurement in vivo

8. Ambulatory measurements of pulsatile hemodynamics

9. Animal Models and Ex-vivo Methods to Study Arterial Stiffness

Section II. Basic and Applied Physiology

10. Hemodynamic role of the Aorta

11. Wave Reflections in the arterial tree

12. Linking Arterial Stiffness to Microvascular Remodeling

13. Myocardial function: from myofilaments to cardiac pump

14. Systolic-diastolic coupling

15. Ventricular-arterial coupling: The pressure-volume plane

16. Myocardial wall stress and the systolic loading sequence

17. Assessment of Ventricular Arterial Interactions via arterial pressure-flow relations in humans

18. Hemodynamic Determinants of Myocardial Oxygen Demand and Supply

Section III. Biologic pathways leading to arterial stiffness and dysfunctional pulsatile hemodynamics

19. Role of elastin and elastin-derived peptides in arterial stiffness: from synthesis to potential therapeutic interventions

20. Inflammation and arterial stiffness

21. Mechanisms of Aortic Wall Calcification

22. Vascular smooth muscle dysfunction and arterial stiffness

23. Endothelial cell dysfunction and Senescence: Biologic mechanisms and Hemodynamic consequences

24. Autonomic and neuroendocrine modulation of arterial stiffness and hemodynamics

25. Cellular mechanisms of ageing and their impact on the aortic/arterial wall

SECTION IV. Clinical significance of arterial stiffness and pulsatile hemodynamics

26. Normal Aging: Arterial Stiffness and remodeling over the life course

27. Early Vascular Aging and Supernormal Vascular Aging: Genetics, Epigenetics, and Environment

28. Ethnic differences in arterial stiffness and central aortic hemodynamics

29. Arterial Stiffness and Pulsatile hemodynamics in Systemic Hypertension

30. Arterial Stiffness and Pulsatile hemodynamics in Diabetes and Obesity

31. Cardiovascular Risk Prevention in Clinical Practice: Current Guidelines in the USA and Europe

32. Cardiovascular Risk Prevention in Clinical Practice: Current Guidelines in Asia

33. Arterial Stiffness, Cardiovascular Risk and Strategies for enhancing risk Stratification

34. Role of the arterial tree in Physiologic Adaptations to exercise

35. Invasive Hemodynamic Assessments during exercise: Normal patterns and clinical value

36. Arterial Stiffness and Pulsatile hemodynamics in Heart Failure with Reduced and Preserved Ejection Fraction

37. Ventricular-Arterial Coupling and Arterial Load in Aortic Valvular Disease

38. Arterial Stiffness and Atherosclerosis: Mechanistic and Pathophysiologic Interactions

39. Arterial Stiffness and Pulsatile hemodynamics in Coronary Artery Disease and other forms of Atherosclerotic vascular diseases

40. Arterial Stiffness and Pulsatile hemodynamics in Renal disease -

41. Arterial Stiffness, Pulsatile hemodynamics, Cognitive dysfunction

42. Arterial Stiffness and Pulsatile hemodynamics in pregnancy and pregnancy-related vascular complications

43. Arterial Stiffness and Pulsatile Hemodynamics in Pediatric populations

44. Aortopathies and Arteriopathies

45. Pulsatile hemodynamics and arterial stiffness in primary aortopathies

46. Arterial Hemodynamics and Pulsatile Hemodynamics in Congenital Heart Disease

47. Arterial Stiffness and Pulsatile Hemodynamics in Acute and Chronic Infectious Diseases

48. Arterial Stiffness, Hemodynamics and Microvascular Complications in conditions characterized by low arterial pulsatility

SECTION V. Therapeutic approaches to improve arterial stiffness and pulsatile hemodynamics

49. Effects of common antihypertensive treatments on pulsatile arterial hemodynamics

50. Pharmacologic approaches to reduce arterial stiffness

51. Organic and dietary nitrates, inorganic nitrite, NO donors, and sCG stimulation

52. Effect of Exercise Training and Weight Loss on Arterial Stiffness and Pulsatile Hemodynamics

53. Dietary Salt and Arterial Stiffness

54. Role of Arterial Stiffness and Central Hemodynamics in Personalized medicine in hypertension

Section VI. Arterial Stiffness and Pulsatile Hemodynamics in the Pulmonary Circulation

55. Pulsatile hemodynamics and Ventricular-Arterial Interactions in the pulmonary circulation: Physiologic Concepts

56. Pulmonary arterial load and its impact on the right ventricle in pulmonary hypertension

57. Biologic mechanisms and consequences of pulmonary artery stiffening in Pulmonary Hypertension

58. Therapeutic approaches to improve right ventricular load


No. of pages:
© Academic Press 2021
1st October 2021
Academic Press
Hardcover ISBN:

About the Editor

Julio Chirinos

Julio A. Chirinos, MD, PhD, FAHA, FESC Associate Professor of Medicine Adjunct Faculty, Center for Magnetic Resonance and Optical Imaging University of Pennsylvania Perelman School of Medicine Associate Editor, Circulation: Heart Failure Vice-President elect, North American Artery

Affiliations and Expertise

Director, Core Laboratory and Associate Professor of Medicine, University of Pennsylvania Perelman School of Medicine, USA

Ratings and Reviews