Applied Dermatotoxicology

1st Edition

Clinical Aspects

Print ISBN: 9780124201309
eBook ISBN: 9780124201996
Imprint: Academic Press
Published Date: 15th May 2014
Page Count: 150
31.95 + applicable tax
24.99 + applicable tax
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Applied Dermatotoxicology: Clinical Aspects provides concise, systematic, and state-of-the-art information on the toxicological effects of substances on skin, and recent advances in dermal toxicity testing.

This book specifically addresses the clinical presentations borne out of exposure to a variety of chemicals. It begins with an overview of skin biology to provide toxicologists with a basic understanding of its anatomy and physiology. Next it presents a variety of dermatotoxicological effects, as well at the toxic agents that cause them, with color photographs to illustrate these effects.

Applied Dermatotoxicology: Clinical Aspects is an essential reference for toxicologists in industry, and for those medical professionals who encounter cases of dermal exposure to toxic agents.

Key Features

  • A concise, yet inclusive review of effects of chemical exposure
  • Includes background on basic skin biology
  • Provides vital clinical reference for toxicologists in non-clinical settings


Applied Dermatotoxicology: Clinical Aspects is intended for toxicologists, and for those medical professionals who encounter cases of dermal exposure to toxic agents.

Table of Contents

  • List of Contributors
  • Preface
  • Chapter 1. Skin Structure and Function

    • Introduction
    • Structure and Function
    • Skin Appendages
    • Skin a Route of Entry
    • Measuring Skin
    • References
  • Chapter 2. Irritant Contact Dermatitis: Clinical Aspects

    • Introduction
    • Clinical Manifestations of Irritant Dermatitis
    • Special Clinical Forms of Irritant Dermatitis
    • Summary
    • Toxicology
    • References
    • References
  • Chapter 3. Photoirritation (Phototoxicity): Clinical Aspects

    • Introduction
    • Basic Principles of Photobiology
    • Mechanisms of Phototoxic Reactions
    • Clinical Presentations
    • Main Topical and Systemic Photosensitizers
    • Summary
    • Phototoxicity Testing
    • References
    • References
  • Chapter 4. Allergic Contact Dermatitis: Clinical Aspects

    • Introduction
    • ACD Syndrome
    • Stage 1 of ACDS
    • Stage 2 of ACDS
    • Stage 3 of ACDS
    • ICD Versus ACD: Clinical Aspects
    • Hand Eczema (Hand Dermatitis) and ACD
    • Photoallergic Contact Dermatitis
    • ACD: The Patch Test, First-Line Diagnostic Tool
    • The Series of Patch Test Allergens
    • The Panoply of Additional Diagnostic Tools
    • Testing End-Products with Unknown Components
    • Treatment
    • Toxicology of Skin Sensitization
    • References
    • References
  • Chapter 5. Photoallergic Contact Dermatitis: Clinical Aspects

    • Definition and Background
    • History
    • Epidemiology
    • Mechanisms and Pathogenesis
    • Clinical Presentation of Photoallergic Contact Dermatitis
    • Investigation
    • Photopatch Testing Technique
    • Test Procedure
    • Test Material
    • Reading and Interpretation of Results
    • Current Common Topical Photoallergens
    • <


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© Academic Press 2014
Academic Press
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" excellent introduction to the extremely valuable text for anybody interested in how chemical and environmental factors can impact adversely on the skin."- btsNews

"It discusses the nuances and current knowledge on performing testing…written for researchers and dermatologists interested in contact and irritant dermatitis on a basic science level. Score: 79 - 3 Stars",December 19,2014