Applications of Nuclear and Radiochemistry

1st Edition - January 1, 1982
Editors: Richard M. Lambrecht, Nabil Morcos
Language: English
eBook ISBN:
9 7 8 - 1 - 4 8 3 1 - 6 2 3 0 - 0

Applications of Nuclear and Radiochemistry is a collection of articles focusing on contemporary applied research on radioactive isotopes. The monograph is based on the Second… Read more

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Applications of Nuclear and Radiochemistry is a collection of articles focusing on contemporary applied research on radioactive isotopes. The monograph is based on the Second Chemical Congress of the North American Continent, held at Las Vegas, Nevada in August 1980. The book contains articles on developments in nuclear chemistry and radiochemistry, emphasizing the topic of radiopharmaceutical chemistry. The text is composed of two parts, wherein the first part is comprised of papers dealing with advances in the production of radionuclides for nuclear medicine, in the synthesis of labeled pharmaceuticals, and in the design and use of specific diagnostic agents. These sections cover research areas on machines used for research, such as compact accelerators, positron emission, and single photon tomographs. Emphasis is given to the radiochemistry and design of radiopharmaceuticals for receptor studies and for determining physiological function and metabolism of the brain, heart, and tumors. The second part examines contemporary advances including the impact of radiochemistry in China pertaining to the fallout from Chinese nuclear tests. This part also contains a section covering a list of uncommon topics. The text is of interest to nuclear scientists, academicians in the field of radiology and radiochemistry, researchers in nuclear medicine, nuclear engineers, and environmental researchers.

Foreword

Preface

Contributing Authors

1. Introduction

Part I. Radiopharmaceutical Chemistry

Radionuclide Production and Generators

2. Production and Radiochemical Process Control for Short-Lived Medical Radionuclides

3. Production and Use of 13N Gases and Aerosols

4. Research-Scale Experimentation on the Production and Purification of Spallogenic 68Ge at Los Alamos for Nuclear Medicine Applications

5. Production and Purification of 52Fe

6. Biomedical Positron Generators

7. 202Pb/202Tl: A Permanent Radioactivity Reference and Minigenerator For 202T1

8. A New 1910S-191mIr Radionuclide Generator for First Pass Angiography

9. A Commercial Viewpoint for the Production of Radiopharmaceuticals

Radiopharmaceutical Synthesis and Labeling

10. Bifunctional Chelating Agents: Linking Radiometals to Biological Molecules

11. Radiolabeled Blood Cells: Agents for Diagnostic and Kinetic Studies

12. The Use of 99Tc and 99mTc in the Development and Characterization of New Radiotracers for Diagnostic Nuclear Medicine

13. The Inorganic Chemistry of 99mxc Myocardial Imaging Agents

14. Kit for In Vitro Labeling of Red Blood Cells with 99mTc

15. Organic Synthesis Involving 18F

16. Synthesis and Initial Evaluation of a Cimetidine Analog Labeled with 75Se

17. Rapid and Mild Syntheses of Radioiodinated Estrogen Derivatives via Organoborane Technology

18. Radioiodine-Labeled Amines as Brain Imaging Agents

19. Activable Tracers in the Study of Aerosol Deposition and Distribution in In Lung

Radiopharmaceutical Design

20. The Design of Potential Radiopharmaceuticals Based on Structure-Activity Relationships

21. Cerebral Functional Activity Mapped with 18F-2-Deoxy-2-Fluoro-D-Glucose

22. 11C-Radiopharmaceuticals for Brain Receptor Studies in Conjunction with Positron Emission Tomography

23. Radiotracers for Cerebral Blood Flow and Positron Emission Tomography

24. The Development of Muscarine Cholinergic Receptor-Binding Radiotracers

25. A Comparison of 0-(2-Iodobenzoyl)-Choline and 0-(2-Iodobenzoyl)-ß-Methyl Choline as Radiotracers for Myocardial Studies

26. Estrogen Receptor-Based Agents for Imaging Breast Tumors: Binding Selectivity as a Basis for Design and Optimization

27. Radioactive Labeling of Fatty Acids for Metabolic Studies

28. The Influence of Chain Length on the Myocardial Uptake of 75Se-Labeled Fatty Acids

29. The Mechanism of Tumor Localization of Gallium: An Update and Reassessment

Part II. Contemporary Advances

Impact of Radiochemistry in China

30. Photoreduction of the Uranyl Ion in an Aqueous Sulfuric and Ethanol Solution with a CW He-Cd Laser: Quantum Yield and Apparent Rate

31. A Study of Some Complex Compounds of Uranyl and Thorium Salts with Crown Ether

32. Analogue Study for Recovery of Am and Cm from the High Level Waste of Reactor Fuel with High Pressure Chromatography. Part 1. Steady-State Migration Rate of the Band. Part 2. The Composition of the Steady Zone

33. Separation of Rb and Cs by Extraction Ion Exchange

34. Determination of Light Elements in High Purity Materials by Charged Particle Activation Analysis

35. The Origin of Excess Polonium-210 in Natural Waters

36. The Measurement of Airborne Radionuclides Over Japan Since 1974

37. Use of Radioactive Isotopes as Atmospheric Tracers

Nuclear Probes

38. Application of Hot Atom Chemistry Techniques as an Indicator of Solute-Solute Interactions in Liquid and Frozen Water

39. Recovery of Underexposed Images by Autoradiographic Intensification Method

40. Radioactive and Stable Isotopes in the Early Solar System

41. Muonium Spin Rotation Applications to Model Biological Systems

42. Reference Nuclear Data

Glossary of Terms