Antioxidants in Food, Vitamins and Supplements - 1st Edition - ISBN: 9780124058729, 9780124059177

Antioxidants in Food, Vitamins and Supplements

1st Edition

Prevention and Treatment of Disease

Authors: Amitava Dasgupta Kimberly Klein
Hardcover ISBN: 9780124058729
eBook ISBN: 9780124059177
Imprint: Elsevier
Published Date: 20th March 2014
Page Count: 360
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Antioxidants in Food, Vitamins and Supplements bridges the gap between books aimed at consumers and technical volumes written for investigators in antioxidant research. It explores the role of oxidative stress in the pathophysiology of various diseases as well as antioxidant foods, vitamins, and all antioxidant supplements, including herbal supplements. It offers healthcare professionals a rich resource of key clinical information and basic scientific explanations relevant to the development and prevention of specific diseases. The book is written at an intermediate level, and can be easily understood by readers with a college level chemistry and biology background.

Key Features

  • Covers both oxidative stress-induced diseases as well as antioxidant-rich foods (not the chemistry of antioxidants)
  • Contains easy-to-read tables and figures for quick reference information on antioxidant foods and vitamins
  • Includes a glycemic index and a table of ORAC values of various fruits and vegetables for clinicians to easily make recommendations to patients


Primary: health care professionals including practicing physicians, resident physicians, nurse practitioners and pharmacists; Secondary: pathologists, clinical chemists and toxicologists will also buy the book because these health care professionals are interested in developing laboratory tests.

Table of Contents


Chapter 1. Introduction to Free Radicals and the Body’s Antioxidant Defense

1.1 Introduction

1.2 Free Radicals

1.3 The Body’s Antioxidant Defense

1.4 Conclusion


Chapter 2. Methods for Measuring Oxidative Stress in the Laboratory

2.1 Introduction

2.2 Measuring Total Antioxidant Capacity

2.3 Markers of Oxidative Stress in Human Blood and Other Parameters

2.4 Markers of Lipid Peroxidation

2.5 Markers of Protein and DNA Damage

2.6 Measurement of Antioxidant Enzymes and Other Compounds

2.7 Electron Spin Resonance and Related Methods to Study Free Radicals

2.8 Conclusion


Chapter 3. Oxidative Stress Induced by Air Pollution and Exposure to Sunlight

3.1 Introduction

3.2 Composition of Polluted Air

3.3 Outdoor Air Pollution is Linked to Many Diseases

3.4 Indoor Air Quality is also Linked to Diseases

3.5 Air Pollution and Diseases: Role of Oxidative Stress

3.6 Air Quality: Seasonal Variation and Urban Versus Rural Area

3.7 Air Quality Index: Cleanest and Dirtiest US Cities

3.8 Exposure to Sunlight and the Ultraviolet Index

3.9 Exposure to Sunlight, Oxidative Stress, and Skin Cancer

3.10 Exposure to Sunlight, Oxidative Stress, and Ophthalmological Disorders

3.11 Conclusion


Chapter 4. Oxidative Stress Caused by Cigarette Smoking, Alcohol Abuse, and Drug Abuse

4.1 Introduction

4.2 Cigarette Smoking in the United States and Related Health Hazards

4.3 Alcohol and Drug Abuse in the United States

4.4 Conclusion


Chapter 5. Oxidative Stress Induced by Household Chemicals

5.1 Introduction

5.2 Various Household Products and Their Active Ingredients

5.3 Glue and Solvent Abuse: A Significant Problem with Adolescents

5.4 Skin Contact with Household Chemicals and Oxidative Stress

5.5 Conclusion


Chapter 6. Psychological Stress-Induced Oxidative Stress: Differences Between Personality Types, Gender, and Race

6.1 Introduction

6.2 Effect of Stress on HPA Axis, Cortisol, and Other Biomolecules

6.3 Psychological Stress Induces Oxidative Stress: Role of Elevated Cortisol Level

6.4 Effect of Personality Traits on Experiencing Psychological Stress

6.5 Gender Difference in Experiencing Psychological Stress

6.6 Cortisol and Ethnicity: Effect of Psychological Stress

6.7 Conclusion


Chapter 7. Oxidative Stress and Cardiovascular Diseases

7.1 Introduction

7.2 Oxidative Stress and Mechanism of Atherosclerosis

7.3 Elevated Levels of Markers of Oxidative Stress in Patients with Cardiovascular Diseases

7.4 Exercise, Yoga, Oxidative Stress, and Cardiovascular Diseases

7.5 Diet, Oxidative Stress, and Cardiovascular Diseases

7.6 Dietary Supplements and Cardiovascular Diseases

7.7 Conclusion


Chapter 8. Oxidative Stress and Cancer

8.1 Introduction

8.2 Link Between Oxidative Stress and Cancer

8.3 Oxidative Stress Generated by Chemotherapy and Radiation Therapy in Cancer Patients

8.4 Bladder Cancer and Oxidative Stress

8.5 Breast Cancer and Oxidative Stress

8.6 Colon and Rectal Cancer and Oxidative Stress

8.7 Kidney Cancer and Oxidative Stress

8.8 Liver Cancer and Oxidative Stress

8.9 Leukemia and Oxidative Stress

8.10 Lung Cancer and Oxidative Stress

8.11 Oral (Head and Neck) Cancer and Oxidative Stress

8.12 Melanoma and Oxidative Stress

8.13 Ovarian Cancer and Oxidative Stress

8.14 Pancreatic Cancer and Oxidative Stress

8.15 Prostate Cancer and Oxidative Stress

8.16 Thyroid Cancer and Oxidative Stress

8.17 Diet/Dietary Supplementation, Cancer, and Oxidative Stress

8.18 Exercise, Cancer, and Oxidative Stress

8.19 Conclusion


Chapter 9. Diabetes and Oxidative Stress

9.1 Introduction

9.2 Various Types of Diabetes

9.3 Elevated Markers of Oxidative Stress in Patients with Diabetes Mellitus

9.4 Hyperglycemia, Oxidative Stress, and Impaired Insulin Secretion

9.5 Diabetic Complications, Morbidity, and Oxidative Stress

9.6 Exercise, Oxidative Stress, and Diabetes

9.7 Diet, Oxidative Stress, and Diabetes

9.8 Antioxidant Supplementation, Oxidative Stress, and Diabetes

9.9 Conclusion


Chapter 10. Role of Oxidative Stress in Neurodegenerative Diseases and Other Diseases Related to Aging

10.1 Introduction

10.2 Role of Oxidative Stress in Aging

10.3 Oxidative Stress and Age-Related Neurodegenerative Diseases

10.4 Parkinson’s Disease and Oxidative Stress

10.5 Huntington Disease and Oxidative Stress

10.6 Amyotrophic Lateral Sclerosis and Oxidative Stress

10.7 Alzheimer’s Disease and Oxidative Stress

10.8 Oxidative Stress and Age-Related Eye Disease

10.9 Oxidative Stress and Age-Related Hearing Loss

10.10 Oxidative Stress and Age-Related Musculoskeletal System

10.11 Oxidative Stress, the Integumentary System, and Skin Appendages

10.12 Role of Genetic Variability and Lifestyle in Response to Oxidative Stress/Aging

10.13 Conclusion


Chapter 11. Oxidative Stress Related to Other Diseases

11.1 Introduction

11.2 Alcohol Abuse and Oxidative Stress

11.3 Drug Abuse and Oxidative Stress

11.4 Role of Oxidative Stress in Liver and Kidney Disease

11.5 Elevated Oxidative Stress in Patients with Diseases Linked to Chronic Inflammation

11.6 Increased Oxidative Stress in Patients with Asthma, COPD, and Related Diseases

11.7 Oxidative Stress in Patients with Seizure

11.8 Oxidative Stress in Transplant Patients

11.9 Oxidative Stress in Psychiatric Disorders

11.10 Other Diseases Linked to Elevated Oxidative Stress

11.11 Conclusion


Chapter 12. Fruits, Vegetables, and Nuts: Good Sources of Antioxidants

12.1 Introduction

12.2 Various Antioxidants in Fruits and Vegetables

12.3 Organic Food Versus Processed Food

12.4 Fruits and Vegetables Rich in Antioxidant Vitamins

12.5 USDA Dietary Guidelines and Amount of Antioxidant Phytochemicals Consumed by Americans

12.6 Relation Between Food and Vegetable Consumption and Reduced Oxidative Stress

12.7 Conclusion


Chapter 13. Tea, Coffee, and Chocolate: Rich Sources of Antioxidants

13.1 Introduction

13.2 Consumption of Tea and Coffee

13.3 Chocolate: A Historical Perspective

13.4 Tea, Coffee, and Chocolate: Glycemic Index

13.5 Conclusion


Chapter 14. Alcoholic Beverages: Antioxidant and Other Health Benefits of Moderate Consumption

14.1 Introduction

14.2 Alcoholic Beverages: Alcohol Content

14.3 Antioxidants Present in Beer

14.4 Antioxidants Present in Wine

14.5 Alcohol Increases Antioxidant Levels in Strawberries and Blackberries

14.6 Guidelines for Drinking in Moderation

14.7 The French Paradox and Health Benefits of Drinking in Moderation

14.8 Antioxidant and Pro-Oxidant Effects of Alcoholic Beverages

14.9 Beneficial Effects of Alcohol on the Heart: Are These Effects Due To Polyphenolic Compounds Alone?

14.10 Health Benefits of Dealcoholized Beverages

14.11 Conclusion


Chapter 15. Antioxidant Vitamins and Minerals

15.1 Introduction

15.2 Vitamin C: The Only Water-Soluble Antioxidant Vitamin

15.3 Vitamin E: Fat-Soluble Antioxidant Vitamin

15.4 Vitamin A and β-Carotene: Fat-Soluble Antioxidants

15.5 Antioxidant Trace Element Selenium

15.6 Is There Any Health Benefit to Antioxidant Vitamin/Mineral Supplementation?

15.7 Conclusion


Chapter 16. Herbal and Other Dietary Supplements That Are Antioxidants

16.1 Introduction

16.2 Antioxidant Herbal Supplements

16.3 Other Antioxidant Supplements

16.4 Conclusion


Chapter 17. Combating Oxidative Stress with a Healthy Lifestyle

17.1 Introduction

17.2 Interaction with Friends/Family Members and Laughter to Reduce Stress

17.3 Insomnia and Oxidative Stress: The Need for a Good Night’s Sleep

17.4 Health Benefits of Pet Ownership and Human–Animal Interaction

17.5 Meditation and Yoga to Combat Stress and Improve Antioxidant Defense

17.6 Benefits of Physical Activity and Exercise

17.7 Aromatherapy and Massage for Stress Reduction

17.8 Music for Stress Reduction

17.9 Sex for Stress Reduction

17.10 Leisurely Activities and Vacation for Stress Reduction

17.11 Conclusion




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About the Author

Amitava Dasgupta

Amitava Dasgupta received his PhD degree in Chemistry from Stanford University and his fellowship training in Clinical Chemistry from the Laboratory Medicine Department of the University of Washington School of Medicine at Seattle. He is a tenured Full Professor of Pathology and Laboratory Medicine at the University of Texas Health Sciences Center located at the Texas Medical Center at Houston. Dr. Dasgupta has published 210 scientific papers, written many invited review articles, and has edited, co-edited or written 15 books. He is on the Editorial Board of five major medical journals including American Journal of Clinical Pathology, Archives of Pathology and Laboratory Medicine, Therapeutic Drug Monitoring, Clinica Chimica Acta and Journal of Clinical Laboratory Analysis.

Affiliations and Expertise

Professor, Pathology and Laboratory Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA

Kimberly Klein

Kimberly Klein received her undergraduate degree in nutrition from the University of Florida and her Doctoral of Medicine degree from the University of Miami Miller School of Medicine. She completed her residency training in the department of pathology at University of Texas Health Sciences Center and her sub-specialization training in the field transfusion medicine at Baylor College of Medicine. She is an Assistant Professor of Pathology and Laboratory Medicine at the University of Texas Health Sciences Center located at the Texas Medical Center at Houston. She has several published papers in field of pathology in the in Transfusion, surgical infection, disease of the month, and the Journal of Breast.

Affiliations and Expertise

Assistant Professor, Department of Pathology and Laboratory Medicine, University of Texas – Houston Medical School, USA