Antioxidants in Disease Mechanisms and Therapy

Antioxidants in Disease Mechanisms and Therapy

1st Edition - October 9, 1996

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  • Editor: Lester Packer
  • eBook ISBN: 9780080581309

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Antioxidants in Disease Mechanisms and Therapy presents molecular actions of natural and synthetic antioxidants and emphasizes the potential role in disease mechanisms and therapeutic strategies. The modulationof gene expression by the induction of antioxidant enzymes is a novel role beyond the direct antioxidant action. The volume explores the current state of knowledge on oxidants and antioxidants in disease processes, including arteriosclerosis, adult respiratory distress syndrome, cystic fibrosis, Down's syndrome, inflammation, cataract, age-related macular degeneration, afflications of the nervous system, AIDS, liver diseases, diabetes, skin diseases, and cancer.

Key Features

  • Contains cutting-edge information on focused topics written by expert scientists
  • Provides the first in-depth treatment of novel compounds, such as melatonin and polyamines
  • Attempts molecular pathophysiology which links basic science and the clinic
  • Presents critical assessment of controversial topics


Students and researchers in pharmacology, biochemistry, and other biomedical disciplines. Academic neurologists, neuroscientists, and immunologists.

Table of Contents

  • Natural Antioxidants:
    B. Halliwell, Antioxidants: The Basics--What They are and How to Evaluate Them.
    A.M. Bode, Metabolism of Vitamin C in Health and Disease.
    M.G. Traber, Regulation of Human Plasma Vitamin E.
    M.E. Anderson, Glutathione and Glutathione Delivery Compounds.
    L. Packer, S. Roy, and C.K. Sen, a-Lipoic Acid: A Metabolic Antioxidant and Potential Redox Modulator of Transcription.
    R.J. Reiter, Antioxidant Actions and Melatonin.
    E. Lovaas, Antioxidative and Metal Chelating Effects of Polyamines.
    L.G. Korkina and I.B. Afanas'ev, Antioxidant and Chelating Properties of Flavonoids.
    Synthetic Antioxidants and Enzyme Mimics:
    J.-B. Galey, Potential Use of Iron Chelators Against Oxidative Damage.
    I.A. Cotgreave, N-Acetylcysteine: Pharmacological Considerations, Experimental and Clinical Applications.
    H. Sies and H. Masumoto, Ebselen as a Glutathione Peroxidase Mimic and as a Scavenger of Peroxynitrite.
    S.R. Doctrow, K. Huffman, C.B. Marcus, W. Musleh, A. Bruce, M. Baudry, and B. Malfroy, Salen Manganese Complexes: Combined Superoxide Dismutase/Catalase Mimics with Broad Pharmacological Efficacy.
    Antioxidant Enzyme Induction and Pathophysiology: A.C. Allison, Antioxidant Drug Targeting.
    T. Primiano, T.R. Sutter, and T.W. Kensier, Antioxidant-Inducible Genes.
    G. Powis, J.R. Gasdaska, and A. Baker, Redox Signaling and the Control of Cell Growth and Death.
    R.A. Floyd, Protective Action of Nitrone Based Free Radical Traps Against Oxidative Damage to the Central Nervous System.
    J.B. de Haan, E.J. Wolvetang, F. Cristiano, R. Iannello, C. Bladier, M.J. Kelner, and I. Kola, Reactive Oxygen Species and Their Contribution to Pathology in Down Syndrome.
    P.G. Winyard and D.R. Blake, Antioxidants Redox-Regulated Transciption Factor and Inflammation.
    Disease Processes:
    H. Esterbauer, R. Schmidt, and M. Hayn, Relationships between Oxidation of LDL, Antioxidant Protection and Atherosclerosis.
    S. Louie, B. Halliwell, and C.E. Cross, Adult Respiratory Distress Syndrome: A Radical Perspective.
    A. van der Vliet, J.P. Eiserich, G.P. Marelich, B. Halliwell, and C.E. Cross, Oxidative Stress in Cystic Fibrosis: Does It Occur and Does It Matter?
    A. Taylor and T. Nowell, Oxidative Stress and Antioxidant Function in Relation To Risk for Cataract.
    J.T. Landrum, R.A. Bone, and M.D. Kilburn, The Macular Pigment: A Possible Role in Protection from Age-Related Macular Degeneration.
    D.P.R. Muller, Neurological Disease.
    W. Dröge, A. Grob, V. Hack, R. Kinscherf, M. Schykowski, M. Bockstette, S. Mihm, and D. Galter, Role of Cysteine and Glutathione in HIV Infection and Cancer Cachexia-Therapeutic Intervention with N-Acetyl-Cysteine.
    C.S. Lieber, Role of Oxidative Stress and Antioxidant Therapy in Alcoholic and Nonalcoholic Liver Disease.
    B. Heller, V. Burkart, E. Lampeter, and H. Kolb, Antioxidant Therapy for the Prevention of Type I Diabetes.
    K. Scharfetter-Kochanek, Photoaging of the Connective Tissue of the Skin, Its Prevention and Therapy.
    S. Taylor, Antioxidant Nutrients and Cancer Incidence and Mortality: An Epidemiologic Perspective.
    Chapter References.
    Subject Index.

Product details

  • No. of pages: 707
  • Language: English
  • Copyright: © Academic Press 1996
  • Published: October 9, 1996
  • Imprint: Academic Press
  • eBook ISBN: 9780080581309

About the Serial Volume Editor

Lester Packer

Lester Packer
Lester Packer received a PhD in Microbiology and Biochemistry in 1956 from Yale University. In 1961, he joined the University of California at Berkeley serving as Professor of Cell and Molecular Biology until 2000, and then was appointed Adjunct Professor, Pharmacology and Pharmaceutical Sciences, School of Pharmacy at the University of Southern California.

Dr Packer received numerous distinctions including three honorary doctoral degrees, several distinguished Professor appointments. He was awarded Chevalier de l’Ordre National du Merite (Knight of the French National Order of Merit) and later promoted to the rank of Officier. He served as President of the Society for Free Radical Research International (SFRRI), founder and Honorary President of the Oxygen Club of California.

He has edited numerous books and published research; some of the most cited articles have become classics in the field of free radical biology:

Dr Packer is a member of many professional societies and editorial boards. His research elucidated - the Antioxidant Network concept. Exogenous lipoic acid was discovered to be one of the most potent natural antioxidants and placed as the ultimate reductant or in the pecking order of the “Antioxidant Network” regenerating vitamins C and E and stimulating glutathione synthesis, thereby improving the overall cellular antioxidant defense. The Antioxidant Network is a concept addressing the cell’s redox status. He established a world-wide network of research programs by supporting and co-organizing conferences on free radical research and redox biology in Asia, Europe, and America.

Affiliations and Expertise

Department of Molecular Pharmacology and Toxicology, School of Pharmaceutical Sciences, University of Southern California, USA

About the Serial Editors

J. August

Affiliations and Expertise

John Hopkins University; Department of Pharmacology, Baltimore, Maryland, U.S.A.

Ferid Murad

Ferid Murad was born in Whiting, Indiana. Working concurrently on an M.D. and Ph.D. in Pharmacology, Dr. Murad graduated with both degrees from Case Western Reserve University, Cleveland, Ohio, in 1965. His many honors include the Alfred S. Maschke Award for Clinical Excellence from Case Western Reserve University in 1965. He has held several distinguished positions, including Acting Chairman in the Department of Medicine and Acting Division Chief, Division of Respiratory Medicine at Stanford University. He currently is CEO and President of Molecular Geriatrics Corporation in Lake Bluff, Illinois. Dr. Murad is married and has five children.

Affiliations and Expertise

University of Texas Medical School, Houston, U.S.A.

M. Anders

Affiliations and Expertise

University of Rochester; Department of Pharmacology, New York, U.S.A.

Joseph Coyle

Joseph T. Coyle, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA

Affiliations and Expertise

McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA

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