Antioxidants in Disease Mechanisms and Therapy presents molecular actions of natural and synthetic antioxidants and emphasizes the potential role in disease mechanisms and therapeutic strategies. The modulationof gene expression by the induction of antioxidant enzymes is a novel role beyond the direct antioxidant action. The volume explores the current state of knowledge on oxidants and antioxidants in disease processes, including arteriosclerosis, adult respiratory distress syndrome, cystic fibrosis, Down's syndrome, inflammation, cataract, age-related macular degeneration, afflications of the nervous system, AIDS, liver diseases, diabetes, skin diseases, and cancer.

Key Features

@introbul:Key Features @bul:* Contains cutting-edge information on focused topics written by expert scientists * Provides the first in-depth treatment of novel compounds, such as melatonin and polyamines * Attempts molecular pathophysiology which links basic science and the clinic * Presents critical assessment of controversial topics


Students and researchers in pharmacology, biochemistry, and other biomedical disciplines. Academic neurologists, neuroscientists, and immunologists.

Table of Contents

Natural Antioxidants: B. Halliwell, Antioxidants: The Basics--What They are and How to Evaluate Them. A.M. Bode, Metabolism of Vitamin C in Health and Disease. M.G. Traber, Regulation of Human Plasma Vitamin E. M.E. Anderson, Glutathione and Glutathione Delivery Compounds. L. Packer, S. Roy, and C.K. Sen, a-Lipoic Acid: A Metabolic Antioxidant and Potential Redox Modulator of Transcription. R.J. Reiter, Antioxidant Actions and Melatonin. E. Lovaas, Antioxidative and Metal Chelating Effects of Polyamines. L.G. Korkina and I.B. Afanas'ev, Antioxidant and Chelating Properties of Flavonoids. Synthetic Antioxidants and Enzyme Mimics: J.-B. Galey, Potential Use of Iron Chelators Against Oxidative Damage. I.A. Cotgreave, N-Acetylcysteine: Pharmacological Considerations, Experimental and Clinical Applications. H. Sies and H. Masumoto, Ebselen as a Glutathione Peroxidase Mimic and as a Scavenger of Peroxynitrite. S.R. Doctrow, K. Huffman, C.B. Marcus, W. Musleh, A. Bruce, M. Baudry, and B. Malfroy, Salen Manganese Complexes: Combined Superoxide Dismutase/Catalase Mimics with Broad Pharmacological Efficacy. Antioxidant Enzyme Induction and Pathophysiology: A.C. Allison, Antioxidant Drug Targeting. T. Primiano, T.R. Sutter, and T.W. Kensier, Antioxidant-Inducible Genes. G. Powis, J.R. Gasdaska, and A. Baker, Redox Signaling and the Control of Cell Growth and Death. R.A. Floyd, Protective Action of Nitrone Based Free Radical Traps Against Oxidative Damage to the Central Nervous System. J.B. de Haan, E.J. Wolvetang, F. Cristiano, R. Iannello, C. Bladier,


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© 1996
Academic Press
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Electronic ISBN:


@from:Praise for the Serial @qu:"Recommended not only to pharmacologists but also to all those in related disciplines." @source:--NATURE @qu:"The works do represent an extensive compilation of recent data by outstanding researchers in this area. They are generally scientifically excellent, the bibliographies are good, and the individual reports are clear, concise, and extremely well illustrated." @source:--H.E. Kaufmann in CHEMOTHERAPY @qu:"Superb reading material." @source:--JOURNAL OF PHARMACEUTICAL SCIENCES @from:Praise for the Volume @qu:"...a must in the library of researchers in the area of free radical biology... it presents an invaluable indepth critical coverage of topics inherent in the 'antioxidant literature' and ranging from basic physical chemistry concepts to clinical therapy, prevention, and epidemiological perspectives... an excellent book, highly recommended, on topics of great current interest." @source:--Enrique Cadenas for FREE RADICAL RESEARCH @qu:"Comprehensive, concise, well-referenced and original, this book also includes appropriate illustrations to explain the text... This book covers the complete spectrum of the topics dealing with molecular actions of natural and synthetic antioxidants and their potential role in disease states and therapeutic strategies." @source:--Arshad Rahman, PhD, Rush Medical College of Rush University for DOODY'S PUBLISHING REVIEWS @qu:"Comprehensive, concise, well-referenced and original, this book also includes appropriate illustrations to explain the text. The layout is simple and appealing... Weighted numerical score: 90 - 4 stars!" @source:--Arshad Rahman in DOODY PUBLISHING