Antimetabolites in Biochemistry, Biology and Medicine

Proceedings of a Symposium on Antimetabolites in Biochemistry, Biology and Medicine, Held in Prague, Czechoslovakia, July 10-12, 1978

1st Edition - January 1, 1979
Editors: J. Skoda, P. Langen
Language: English
eBook ISBN:
9 7 8 - 1 - 4 8 3 1 - 8 9 0 9 - 3

FEBS: Federation of European Biochemical Societies, Volume 57: Antimetabolites in Biochemistry, Biology, and Medicine is a collection of papers that presents that advancement in… Read more

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FEBS: Federation of European Biochemical Societies, Volume 57: Antimetabolites in Biochemistry, Biology, and Medicine is a collection of papers that presents that advancement in the field of antimetabolites research. The title first covers the use of antimetabolites in enzymology, and then proceeds to tackling the consequences of analog incorporation into nucleic acids. Next, the selection discusses the rational approach to the use of antimetabolite in commination cancer chemotherapy an in immunosuppression. The text also covers the aspects of selective antiviral action. In the last part, the selection details various compounds, along with their synthesis and mechanisms of action. The book will be of great use to researchers and practitioners of biochemistry, biology, and medicine.

Introductory Remarks

Anti-metabolites as Tools in Enzymology

Recent Studies on the Interaction of 5-Fluoro-2'-deoxyuridylate with Thymidylate Synthetase

The Site of Action of Fluorouracil in Relation to the Amino Acid Sequence of Thymidylate Synthetase

Pharmacology of 5-AZA-2'-Deoxycytidine

Inhibitors of Thymidylate Synthetase

The Development of α-(N)-Heterocyclic Carboxaldehyde Thiosemicarbazones as Inhibitors of Ribonucleotide Reductase

Transformation and Incorporation of 5-aza-2'-Deoxycytidine in the Lymphatic System

Consequences of Analog Incorporation into Nucleic Acids

The Effect of 5-Fluoropyrimidines on the Processing of Ribonucleic Acids in Liver

The Interactions of BrdU-Substituted DNA with LAC Repressor and Histones

The Incorporation of Hydroxymethyldeoxyuridine into DNA of Ehrlich Ascites Carcinoma Cells and Some of its Consequences

The Effect of Substrate Modification on Transcription of DNA by DNA-dependent RNA Polymerase

Some Structural Aspects of Nucleoside Antimetabolites, with Particular Reference to Tautomerism and Conformation

Transition State Analogs as Antimetabolites

Rational Approach to the Use of Anti-metabolites in Combination Cancer Chemotherapy and in Immunosuppression

Antimetabolites in Cancer Chemotherapy: Past, Present and Future

Approaches to Improved Therapeutic Selectivity with Methotrexate

Rational Use of Antimetabolites of Specific Amino Acids in Combination Chemotherapy of Cancer

Selectivity of Anticancer Drug Action in the Modulation of the Immune Response

Synthesis, Antineoplastic Effect in Animals with Experimental Tumors, and Some Other Biological Properties of Compound 9777-VUFB (DAMVAR)

Localized Chemotherapy of Solid Experimental Tumors with Macromolecular Carriers Containing Antifolates

Rational Use of Antimetabolites in Cancer Chemotherapy with Special Reference to High Dose Methotrexate/Citrovorum Factor Rescue Therapy

Aspects of Selective Antiviral Action

Selective Inhibition of Oncornaviral Functions (a Molecular Approach)

Strategy for the Development of Selective Anti-Herpes Virus Agents based on the Unique Properties of Viral-induced Enzymes - Thymidine Kinase, DNase and DNA Polymerase

Comparative Study of the Potency and Selectivity of Anti-Herpes Compounds

Molecular Basis for Serendipitous Development of Antiviral and Anticancer Aminonucleosides

New Types of Compounds, their Synthesis and Mechanism of Action

Some Consequences of Inhibition of the de novo Pathway of Pyrimidine Biosynthesis

Manipulation of Purine Nucleotide Concentrations by Antimetabolites

Molecular Targets for Methotrexate

Rational Design of Anti-Herpes Virus Anti-Metabolites

Search for New Antimetabolites and New Latent Forms of Metabolites and Antimetabolites among the Nucleoside Alkylphosphonates

"3-Oxapyrimidines" (Derivatives of 2,3-Di-hydro-1,3-6H-Oxazine) - A New Category of Antimetabolites with a Short Half-life

Author Index

Subject Index