Antimetabolites in Biochemistry, Biology and Medicine - 1st Edition - ISBN: 9780080243849, 9781483189093

Antimetabolites in Biochemistry, Biology and Medicine

1st Edition

Proceedings of a Symposium on Antimetabolites in Biochemistry, Biology and Medicine, Held in Prague, Czechoslovakia, July 10-12, 1978

Editors: J. Skoda P. Langen
eBook ISBN: 9781483189093
Imprint: Pergamon
Published Date: 1st January 1979
Page Count: 384
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FEBS: Federation of European Biochemical Societies, Volume 57: Antimetabolites in Biochemistry, Biology, and Medicine is a collection of papers that presents that advancement in the field of antimetabolites research. The title first covers the use of antimetabolites in enzymology, and then proceeds to tackling the consequences of analog incorporation into nucleic acids. Next, the selection discusses the rational approach to the use of antimetabolite in commination cancer chemotherapy an in immunosuppression. The text also covers the aspects of selective antiviral action. In the last part, the selection details various compounds, along with their synthesis and mechanisms of action. The book will be of great use to researchers and practitioners of biochemistry, biology, and medicine.

Table of Contents

Introductory Remarks Anti-metabolites as Tools in Enzymology Recent Studies on the Interaction of 5-Fluoro-2'-deoxyuridylate with Thymidylate Synthetase The Site of Action of Fluorouracil in Relation to the Amino Acid Sequence of Thymidylate Synthetase Pharmacology of 5-AZA-2'-Deoxycytidine Inhibitors of Thymidylate Synthetase The Development of α-(N)-Heterocyclic Carboxaldehyde Thiosemicarbazones as Inhibitors of Ribonucleotide Reductase Transformation and Incorporation of 5-aza-2'-Deoxycytidine in the Lymphatic System Consequences of Analog Incorporation into Nucleic Acids The Effect of 5-Fluoropyrimidines on the Processing of Ribonucleic Acids in Liver The Interactions of BrdU-Substituted DNA with LAC Repressor and Histones The Incorporation of Hydroxymethyldeoxyuridine into DNA of Ehrlich Ascites Carcinoma Cells and Some of its Consequences The Effect of Substrate Modification on Transcription of DNA by DNA-dependent RNA Polymerase Some Structural Aspects of Nucleoside Antimetabolites, with Particular Reference to Tautomerism and Conformation Transition State Analogs as Antimetabolites Rational Approach to the Use of Anti-metabolites in Combination Cancer Chemotherapy and in Immunosuppression Antimetabolites in Cancer Chemotherapy: Past, Present and Future Approaches to Improved Therapeutic Selectivity with Methotrexate Rational Use of Antimetabolites of Specific Amino Acids in Combination Chemotherapy of Cancer Selectivity of Anticancer Drug Action in the Modulation of the Immune Response Synthesis, Antineoplastic Effect in Animals with Experimental Tumors, and Some Other Biological Properties of Compound 9777-VUFB (DAMVAR) Localized Chemotherapy of Solid Experimental Tumors with Macromolecular Carriers Containing Antifolates Rational Use of Antimetabolites in Cancer Chemotherapy with Special Reference to High Dose Methotrexate/Citrovorum Factor


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© Pergamon 1979
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About the Editor

J. Skoda

P. Langen

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