
Antimalarial Agents
Design and Mechanism of Action
Description
Key Features
- Consolidates both past and current developments in the discovery and design of antimalarial drugs
- Presents content in a style that is both thorough and engaging, providing a supportive and guiding reference to students and researchers from interdisciplinary backgrounds
- Highlights drug targets currently considered to be the most promising for future therapies, and the classes of compounds that are currently being studied and perfected
Readership
Table of Contents
1. History of malaria and its treatment
2. Knowing one's enemy: the Plasmodium parasite
3. The cinchona alkaloids and the aminoquinolines
4. Artemisinin and artemisinin-related agents
5. Agents acting on pyrimidine metabolism
6. Antimalarial agents acting on hemoglobin degradation
7. Plasmepsins as targets for antimalarial agents
8. Falcipains as drug targets in antimalarial therapy
9. Drug targets in the apicoplast
10. Drugs targeting mitochondrial functions
11. The Plasmodium falciparum proteasome as a drug target
12. Transferases and their inhibition
13. Kinases and kinase inhibitors
14. Miscellaneous agents of clinical interest
15. Inhibitors of purine and pyrimidine pathways
16. Miscellaneous targets
Product details
- No. of pages: 622
- Language: English
- Copyright: © Elsevier 2020
- Published: May 30, 2020
- Imprint: Elsevier
- eBook ISBN: 9780081012413
- Paperback ISBN: 9780081012109