Antibody Production in Man  - 1st Edition - ISBN: 9780122499500, 9780323151528

Antibody Production in Man

1st Edition

In Vitro Synthesis and Clinical Implications

Editors: Anthony S. Fauci
eBook ISBN: 9780323151528
Imprint: Academic Press
Published Date: 1st January 1979
Page Count: 412
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Antibody Production in Man: In Vitro Synthesis and Clinical Implications is composed of the proceedings of the Catharijne Conference on immunology held in Utrecht, Holland on March 15-18, 1978. The conference focuses on the in vitro induction and regulation of immunoglobulin and antibody synthesis by human lymphocytes. It aims to present, analyze, exchange, and criticize data among the different investigators and to attempt to resolve apparent inconsistencies and contradictions. The book first discusses the mitogen- and antigen-induced B-cell activation. It then explains the subpopulations of lymphocytes involved in the regulation of in vitro B-cell function and the clinical implications in the study of in vitro B-cell function. This book reflects the stimulation as well as the frustration during the workshop. It will serve as a small force and focus of direction in this most interesting, complex, and relevant area of human immunobiology.

Table of Contents

Contributors Preface 1 Consideration of Antibody Deficiency Diseases in Relation to Normal B-Cell Development 2 Pokeweed Mitogen-Induced Responses of Human Peripheral Blood Lymphocytes: Regulation of B-Cell Triggering 3 Induction of Antibody Synthesis in Human Lymphocytes from Different Organs by Different PBA Substances 4 The Plaque-Forming Cell Response of Human Blood Lymphocytes. Cocultivation of Lymphocytes from Different Individuals General Discussion Mitogen-Induced B-Cell Activation. I. 5 T—T Interactions in the Generation of Human Suppressor Effector Cells in Vitro 6 Biosynthesis and Secretion of Immunoglobuhns by Human Peripheral Blood Lymphocytes 7 Antigen-Specific and Antigen-Nonspecific Triggering of Human B Lymphocytes General Discussion Mitogen-Induced B-Cell Activation. II. 8 Antigen-Induced Regulation of the PFC Response in Man 9 Human B-Cell Activation in Vitro: Regulation by Antigen- Specific Human Suppressor T Cells 10 Primary in Vitro Antibody Response to TNP-PAA: Cellular Basis General Discussion Antigen-Induced B-Cell Activation. I. 11 T-B Collaboration in the in Vitro Ab Response to Diphtheria Toxoid: Evidence Favoring a Role for B Cells in the Generation of T-Cell Help 12 Antigen-Dependent PFC Induction in Cultures of Human Peripheral Blood Lymphocytes 13 Human Antigen-Specific Helper T-Cell Factors in B-Cell Responses General Discussion Antigen-Induced B-Cell Activation. II. 14 Clinical Relevance of Subpopulation of Human T Lymphocytes 15 Further Studies on the IgM Receptors Located on the Surface of B Cells 16 Distinct Human T-Cell Subpopulations Regulating the Antigen-Induced Antibody Response General Discussion Subpopulations of Lumphocytes Involved in the in Vitro Regulation of B-Cell Function. I. 17 Generation of Plaque-Forming Cells: Allogenic Effect and Significance of Monocyte Removal 18 Regulation of Human B-Cell Differentiation by T


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Academic Press
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Anthony S. Fauci

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