Description

Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology.

Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells.

Key Features

  • Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitro
  • Covers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodies
  • Color illustrations enhance explanations of the immune system

Readership

vaccinologists, immunologists, microbiologists, oncologists, protein engineers, in academic and industrial research institutions; graduate students in immunology and vaccinology.

Table of Contents

List of Contributors

1: Effector Mechanisms

Chapter 1. Antibody-Dependent Cellular Cytotoxicity (ADCC)

Brief History of ADCC

Effector Cells

Receptors Involved

Mechanisms of ADCC

ADCC in Monoclonal Antibody Therapy of Cancer

ADCC in Infectious Disease: A Correlate of Protection?

Rational Modification of ADCC Activity

Enhancing the Link between ADCC and Adaptive Immunity

Perspectives: Future Directions

Acknowledgments

References

Chapter 2. Antibody-Dependent Cellular Phagocytosis and Its Impact on Pathogen Control

Introduction

Phagocytic Cells and Their Fcγ Receptors

Fcγ Receptor-Mediated Phagocytosis by Phagocytes

Role of FcγR-Mediated Phagocytosis for Pathogen Uptake, Cellular Localization, and Pathogen Control

Concluding Remarks

References

Chapter 3. Interactions Between the Complement System and Fcγ Receptors

Preliminary Comments

Complement Fragment C3b Mediates Binding of IgG Immune Complexes to Primate Erythrocytes: Immune Adherence

Complement Fragment C3d Mediates Binding of Substrates to CR2 on B Cells: Antigen Trafficking and its Significance in HIV Disease

Cooperation/Synergy between Fcγ Receptors and Complement Receptors on Effector Cells

Cross-Talk between the C5a Receptor and FcγR on Effector Cells

Concluding Remarks

Abbreviations

References

2: Effector Cells

Chapter 4. Natural Killer Cells

Inhibitory Receptor Modules Inform a Useful and Self-Tolerant NK Cell Repertoire

Activating Immunoreceptors Mediate NK Cell Recognition of Tumors and Infected Cells

Adaptive Features of NK Cells

References

Chapter 5. Phagocytes and Immunoglobulins

Antibodies in the Context of Innate and Acquired Immune Recognition

General Characteristics

Details

No. of pages:
358
Language:
English
Copyright:
© 2014
Published:
Imprint:
Academic Press
Electronic ISBN:
9780123948182
Print ISBN:
9780123948021

About the editors

Margaret Ackerman

Margaret E. Ackerman studied molecular engineering at the Massachusetts Institute of Technology under K. Dane Wittrup, followed by postdoctoral studies at the Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University under Galit Alter. She was appointed an Assistant Professor of Engineering at Dartmouth College’s Thayer School of Engineering in 2011, and an Assistant Professor in the Department of Microbiology and Immunology at Dartmouth’s Geisel School of Medicine in 2012. Her research group applies protein engineering, molecular biology, and mathematical modelling tools to design enhanced antibody therapeutics and and vaccines.

Falk Nimmerjahn

Falk Nimmerjahn studied Biology at the Universities of Bayreuth, Erlangen-Nuernberg and Munich in Germany. After his postdoctoral studies in the laboratory of Jeffrey Ravetch at the Rockefeller University in New York from 2004-2007, he was appointed as an Associate Professor at the University Hospital of Erlangen in 2007. Since 2010 he has been a full Professor of genetics and chairman of the Institute of Genetics at the University of Erlangen-Nuernberg in the Department of Biology. His research focuses on understanding the molecular and cellular mechanisms of mouse and human IgG activity. He authored more than 80 peer reviewed papers and several chapters in text books. For his work on immunoglobulin activity he was awarded several prizes, among them the Paul-Ehrlich and Ludwig Darmstädter Award for young scientists.

Reviews

"…highly recommended reading for all students of immunology and scientists involved in the research and development of therapeutic antibodies and vaccines because of its comprehensive coverage of relevant topics…also recommended as an excellent resource for academic, government and company libraries."--mAbs, May/June 2014
"Antibody Fc: Linking Adaptive and Innate Immunity is highly recommended reading for all students of immunology and scientists involved in the research and development of therapeutic antibodies and vaccines because of its comprehensive coverage of relevant topics…The book is also recommended as an excellent resource for academic, government and company libraries."--mAbs, March 21, 2014
"Ackerman and Nimmerjahn offer this volume on the immunological functions of the Fc antibody region. The first two parts discuss effector mechanisms and their mediating cells including antibody-dependent cytotoxicity, the complement system, phagocytosis, natural killer and B cells. Parts III-IV cover general properties of Fc immune receptors, receptor variation amongst species, and the structural variations and glycoside modifications of the Fc domain."--ProtoView.com, February 2014