Antibiotics

Antibiotics

Origin, Nature and Properties

1st Edition - January 1, 1967

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  • Authors: Tadeusz Korzybski, Zuzanna Kowszyk-Gindifer, Wlodzimierz Kurylowicz
  • eBook ISBN: 9781483223056

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Description

Antibiotics: Origin, Nature and Properties, Volume I is a systematic coverage of the sources, varieties, and properties of the antibiotics. This book is organized into two main parts encompassing 13 chapters. This book considers the antibiotics according to their sources. It describes the antibiotics produced by bacteria, Actinomycetes,Fungi imperfecti, Basidiomycetes, algae, lichens and green plants, and those from animal sources. This group of antibiotics includes, streptomycin, the tetracyclines, chloromycetin, the macrolide family of compounds of which erythromycin, magnamycin and spiramycin are members, and the antifungal polyene compounds. The members of each group are arranged according to their chemical and biological similarity. Sections on each antibiotic present complete information, including the name, description of the producing strains, composition of the media, methods of culture, isolation and purification of the antibiotic principle, its physical and chemical properties, antibiotic spectrum, toxicity for laboratory animals, results of treatment of experimental infections, and possible clinical applications. This book is of value to researchers and workers in various medical fields.

Table of Contents


  • Foreword

    Introduction

    Part I Antibiotics Produced by Micro-Organisms of the Order Euhacteriales

    A. Antibiotics Isolated from the Genus Pseudomonas (Pseudomonadaceae)

    Pyocyanine

    Hemipyocyanine

    Antibiotic Ρχ

    Chlororaphin

    Antibiotic Substances from Pseudomonas Aeruginosa

    Pyoluteorin

    Comirin

    Pyolipic Acid

    Pyocyanase

    Pyoklastin

    Viscosin

    B. Antibiotics Isolated from the Genus Micrococcus (Micrococcaceae), Streptococcus, Diplococcus (Lactobacteriaceae), Chromobacterium, Escherichia and Proteus (Enterobacteriaceae)

    Micrococcin

    Nisin

    Diplococcin

    Streptostasin

    Diplomycin

    Mycobactocidin

    Lactobacillin

    Prodigiosin

    Iodinin

    Violacein

    Marcescin

    Xerosin

    Coliformin

    Colicines

    Protaptins

    Antibiotic from Escherichia Coli

    Toxoflavin

    C. Antibiotics Isolated from the Genus Bacillus (Bacillaceae)

    Gramicidin S

    Gramicidin, Tyrocidine, Tyrothricin

    Gramicidin J

    Bacitracin, syn. Ayfivin

    Subtilin

    Licheniformins

    Polymyxins—Aerosporin, Bacillosporin, Circulins

    Colistin, syn. Colimycin

    Alvein

    Bacilipin, Bacilysin

    Bacillin

    Globicin

    Brevin

    Brevolin

    Bacimethrin

    Edein

    Antifungal Antibiotics Produced by Micro-Organisms of Genus Bacillus

    Bacillomyxin

    Bacillomycin

    Antifungal Antibiotics from Bacillus Subtilis

    Fungocin

    Eumycin

    Toximycin

    Antifungal Agents from Bacillus Subtilis

    Datemycin

    Fungistatin, syn. Antibiotic XG

    Mycosubtilin

    Rhizobacidin

    Simplexin

    Polypeptin

    Laterosporins

    Fluvomycin, syn. Efsiomycin, Vivicil, Riomycin

    Cerein

    Tetaine

    Pumilin

    Subtenolin

    Megacine

    Xanthellin

    Esperin

    Iturine

    Neocidin

    Obutin

    Biocerin

    Endosubtilysine

    Colistatin

    Subtilysine, Analysine

    Mycobacillin

    Petrin

    Nigrin

    Antibacterial Substance Produced by Bacillus Natto

    Trypanotoxin

    Polysaccharidases

    Antibiotic Substances from Myxococcaceae

    Part II Antibiotics Produced By Micro-Organisms of the Order Actinomycetales

    A. Macrolides

    Picromycin

    Argomycin

    Methymycin

    Neomethymycin

    Amaromycin

    Narbomycin

    Oleandomycin, syn. Antibiotic P.A. 105, Matromycin

    Erythromycin, syn. Ilotycin

    Magnamycin, syn. Carbomycin, Antibiotic M-4209

    Spiramycin, syn. Foromacidin, Rovamycin

    Angolamycin

    Lankamycin and Lankacidin

    Chalcomycin, syn. Miconomycin

    Substance 446

    Mesenterin

    Griseomycin, syn. Lomycin

    Miamycin

    Albomycetin

    Leucomycin

    Tertiomycin

    Macrolide-Type Antibiotics: PA-108, PA-133A, PA-133B and PA-148

    Tylosin

    Macrocin

    Proactinomycins

    Acumycin

    Cirramycin

    B. Antibiotics Active Against Grampositive Micro-Organisms

    Granaticin

    Novobiocin, syn. Cathomycin, Cathocin, Streptonivicin, Albamycin, Antibiotic P.A.93, Cardelmycin

    Rifamycins

    Amicetin, syn. Sacromycin, Allomycin

    Amicetin Β

    Bamicetin

    Plicacetin

    Actinorhodin

    Thermorubin

    Antibiotic BA-6903

    Indolmycin, Syn. Antibiotic PA-155 A

    Althiomycin

    Teomycic Acid

    Totomycin

    Nitrosporin

    Ramnacin

    Resistomycin

    Exfoliatin

    Sulfactin

    Celesticetin

    Lincomycin

    Proceomycin

    Aureolic Acid

    Monazomycin

    Aburamycin

    Antibiotic Μ 5-18903

    Antibiotic 24-10

    Nocardianin

    Rubidin

    Julymycin B-II

    Rubromycin

    Sarcidin

    Bundlins A and Β

    Pulvomycin

    Vancomycin

    Frenolicin

    Antibiotic K-288

    Thermoviridin

    Actiduins

    Ristocetin, syn. Spontin

    Vinacetin

    Antibiotic L.A. 7017

    Monamycin

    Erigrisin

    Elaiophylin

    Melanosporin

    Antibiotic SKCC 1377

    Antibiotic J4

    Antibiotic 1943

    Bandamycin

    Actinoidin

    Cladomycin

    Actinomycelin

    Coelicolorin

    Colinomycin

    Fuscomycin

    Antibiotic A 116

    Streptin

    Thermomycin

    Antibiotic 19A

    Sax 10 Substance

    Antibiotic from Streptomyces Sp. 340

    Raisnomycin

    Antibiotic 721

    Microsin

    Antibiotic Κ 125a

    Mycetin

    Phthiocol

    C. Polypeptide Antibiotics

    Echinomycin

    Quinomycins

    Bottromycin

    Griseoviridin and Viridogrisein, syn. Etamycin

    Valinomycin

    Leucopeptin

    Amidomycin

    Sideromycins

    Succinimycin

    Nocardamine

    Grisein

    Albomycin

    Danomycin

    Antibiotic LA 5352 and LA 5937

    Staphylomycin, syn. Antibiotic 899, Virginiamycin

    Streptogramin

    Mikamycins

    Antibiotic PA 114

    Ostreogricin, syn. Antibiotic E-129

    Pristinamycin, syn. Antibiotic 7293 R.P., Pyostacin

    Duramycin

    Telomycin

    Crystallomycin

    Amphomycin

    Stendomycin

    Zaomycin

    Aspartocin

    Glumamycin

    Cinnamycin

    Thiostrepton

    Siomycin

    Bryamycin

    Substance A-59 and A-59B

    Viomycin

    Capreomycin, syn. Capromycin

    Ilamycins

    Rufomycins

    Vinactins

    Actinogan

    Peptimycin

    Antibiotic 1415

    Cranomycin

    Phytoactin and Phytostreptin

    Phleomycin

    Antibiotic from Actinomyces 1-21

    Antibiotic from Actinomyces Strain 300

    Evericin

    Aminomycin

    Antibiotic from Streptomyces Sp. (Sackman)

    Antibiotic 6613

    Micromonosporin

    Antibiotic X-5079C

    Actinomycetin

    Geminimycin

    Grizin, syn. Grizemin, Antibiotic IEM I

    Mycomycetin

    Lysozyme of Actinomycetes

    Antibiotic BU 306

    Antibiotic BU 271

    D. The Broad-Spectrum Antibiotics

    Chloramphenicol, syn. Chloromycetin

    Tetracyclines

    Chlortetracychne, syn. Aureomycin, Duomycin

    Oxytetracycline, syn. Terramycin

    Tetracycline, syn. Achromycin, Terracin

    Tetracycline Derivatives

    Synthesis of Tetracyclines

    Biosynthesis of Tetracyclines

    Chelocardin

    Rhodomycins

    Cinerubins

    Pyrromycin

    Rutilantin

    Quinocyclines

    Streptomycin

    Hydroxystreptomycin, syn. Reticulin

    Antibiotic U-12898, syn. Bluensomycin

    Glebomycin

    Trehalosamine

    Hygromycin

    Hygromycin Β

    Homomycin

    Antibiotic 1703-18 Β

    Actinospectacin

    Streptothricin

    Antibiotic A 4788

    Streptohn

    Geomycin

    Roseothricin

    Racemomycins

    Lavendulin

    Actinorubin

    Pleocidin

    Amycin

    Polymycin

    Mycothricin

    Antibiotic 587/13

    Antibiotic A 20

    Antibiotic Ax 18

    Antibiotic 136

    Antibiotic 156

    Phytobacteriomvcin

    Antibiotic EI5

    Neomycins

    Paromomycin, syn. Humatin

    Monomycin

    Zygomycins

    Kanamycins

    Eurymycin

    Colimycin

    Antibiotic 956

    Antibiotic from Streptomyces Sp. (Mukherjee)

    Roseomycin

    Novomycin

    Flavomycin

    Soframycin, syn. Framycetin

    Antibiotic A 6

    Mycerin

    Dextromycin

    Catenulin

    Aminosidin, syn. Crestomycin, Antibiotic 1600, Antibiotic F.I. 5853, Farmiglucin

    Hydroxymycin, Syn. Antibiotic 4915

    Antibiotic GB/229

    Antibiotic Ac 3

    Azomycin

    Antibiotic HA-9

    Thiolutin

    Isobutyrylpyrrothine

    Aureothricin

    Holomycin

    1,6-Dihydroxyphenazine

    N-Acetyltyramine

    Thioaurin

    Thiomycin

    Bleomycin

    Griseolutein

    Chartreusin

    Primycin

    Mycospocidin

    Litmocidin

    Mycorhodin

    Luteomycin

    Xanthomycins

    Levomycin

    Streptozotocin

    Ractinomycin

    Streptolydigin

    Azalomycins Β and F

    Nigericin

    Cyanomycin

    Matamycin

    Violacetin

    Xanthothricin

    Emimycin

    Antibiotic from Streptomyces Tanashiensis

    Ruticin

    Streptocardin

    Rhodocidin

    Flaveolin

    Antibiotic from Streptomyces Sp. (Rolland)

    Antibiotic 10 CM

    Antibiotic from Actinomyces Flavus Strain 2

    Antibiotics from Streptomyces Sp. 1900-IAUR

    Phalamycin

    Actinonin

    Speciomycin

    Miramycin

    Enteromycin

    Fluorin

    Griseococcin

    Gougerotin

    Longisporin

    Monamycin

    Microcins

    Actinolysin

    Primocarcin

    Nocardorubin

    Neonocardin

    E. Antibiotics Active Against Acid-Fast Bacilli

    Acetomycin

    Cycloserine, syn. Seromycin, Oxamycin, Antibiotic P.A. 94, Orientomycin, D-4-Amino-3-Isoxazolidone

    O-Carbamyl-D-Serine

    Actithiazic Acid, Syn. Mycobacidin, Acidomycin

    Elaiomycin

    Mycomycin, Isomycomycin

    Antibiotic HON

    Tubermycins

    Tuberin

    Bovinocidin

    Tubercidin

    Angustmycins

    Psicofuranine

    Antitumour Antibiotic from Helminthosporium

    Grisamine

    Pyridomycin, syn. Antituberculous Antibiotic

    Streptovaricin, syn. Dalacin

    Griseoflavin

    Antibiotic WR 3/17

    Antibiotic D-13

    Anti-Phlei Factor

    Anti-Smegmatis Factor

    Phthiomycin

    Antituberculous Substance From Streptomyces Strain

    Nocardin

    Globisporin

    Antibiotics of Mycobacteria

    F. Antifungal Antibiotics (Polyenes)

    Tetraene Antibiotics

    Fungicidin, syn. Nystatin, Mycostatin

    Pimaricin

    Tennecetin

    Antifungal Antibiotic from Streptomyces 3569, syn. Antimycoin

    Rimocidin

    Chromin

    Protocidine

    Antifungal Antibiotic from a Strain of Streptomyces Sp. Ac2 435

    Tetrin

    Lucensomycin, syn. Etruscomycin, Antibiotic 1163 F.I.

    Sistomycosin

    Antifungal Antibiotics J4 A and J4 Β

    Antifungal Antibiotic 7071 R.P.

    Antibiotic PA 86

    Albofungin

    Antifungal Antibiotic PA 166

    Unamycins

    Pentaene Antibiotics

    Eurocidin

    Fungichromin, Fungichromatin

    Filipin

    Antibiotic A 246, syn. Lagosin

    Pentamycin

    Moldcidins

    Cabicidine

    Capacidin

    Aliomycin

    Antifungal Antibiotic PA 153

    Antifungal Antibiotic A 228

    Hexaene Antibiotics

    Cryptocidin

    Mediocidin

    Fradicin

    Mycelin

    Antifungal Antibiotic 1587-Z 2

    Flavacid

    Endomycin

    Helixins

    Substance D

    Heptaene Antibiotics

    Amphotericin

    Candidin, Candidinin, Candidoin

    Candimycin

    Candicidin

    Ascosin

    Trichomycin

    Perimycin, syn. Antibiotic 1968, Antibiotic NC-1968

    Hamycin

    Antibiotic 26/1, syn. Levorin

    Antibiotic 757

    Antibiotic F-17-C

    Antifungal Antibiotic AYF

    Antifungal Antibiotic 1645

    Antifungal Antibiotic PA 150

    Ayfactin

    Aureofacin

    Antifungal Antibiotics from Streptomyces Sp. 1033 and 1038

    Grubilin

    Antifungal Antibiotic

    G. Antifungal (Non-Polyene) Antibiotics

    Cycloheximide, syn, Actidione

    Viractin

    Protomycin

    Antitumour Substance E-73

    Streptovitacins

    Inactone and Isoactidiones

    Actiphenol

    Streptimidone

    Niromycins

    Naramycin

    Niger Factor

    Nonactin

    Antibiotic FH 3582, syn. Werramycin

    Antibiotic SQ 15859

    Antimycin, syn. Antibiotic 720 A, Virosin, Antipiricullin, Antibiotic from Streptomyces Kitazawaensis

    Blastmycin

    Toyocamycin

    Vengicid

    Fermicidin

    Ascomycin

    Hygroscopin

    Monilin

    Antibiotic PA 132

    Mycoticin

    Cerevioccidin

    Anthelmycin

    Mycolutein

    Oligomycin

    Antibiotic A 272

    Venturicidin

    Antibiotics from Streptomyces X 206, X 464 and X 537 A

    Humidin

    Hygrostatin

    Lustericin

    Dermostatin

    Musarin

    Eumycetin

    Blasticidins

    Blasticidin S

    Pathocidin

    Septacidin

    Cytomycin

    Cellostatin

    Flavensomycin

    Alomycin

    Euhcin

    Seligocidin

    Alboverticiuin

    Flavofungin

    Xanthicin

    Antifungal Substance from a Streptomycete (Thirumalachar)

    Cacaomycetin

    Moldin

    Actinon

    Camphomycin

    Mycelin

    Mycerin (Arai)

    Phaeophacin

    Rotaventin

    Antibiotic Β 74

    Bulging Factor

    Antibiotic P-9

    Antifungal Antibiotic S-39

    Antibiotic A 67

    Antibiotic 30-10

    Vulgarin

    Amylocyanin

    H. Antibiotics Active Against Protozoa

    Puromycin, syn. Stylomycin

    Netropsin, syn. Sinanomycin, Congocidine Antibiotic 1142, Antibiotic T-1384

    Distamycin A

    Antibiotic 2814 A, 2814 P, 2814 Κ

    Antibiotic IA 887

    Nucleocidin

    Anisomycin, syn. Flagecidin

    Borrelidin

    Antitoxoplasmic Substance No. 534

    Streptocin

    Antibiotic 7.080 R.P.

    Antibiotic X-948

    Antibiotic X-1008

    Antibiotic PA 128

    Ascaricidin

    I. Antibiotics Active Against Plant and Animal Viruses

    Nybomycin

    Myxoviromycin

    Amidinomycin

    Chrysomycin

    Aklavin

    Phagolessin A-58

    Phagostatin

    Phagomycin

    Phagocidin

    Grasseriomycin

    Abikoviromycin, syn. Latumcidin

    Achromoviromycin

    Ehrlichin

    Antibiotic Ε 300

    Hehomycin

    Cerulomycin

    Antibiotic F 43

    Antibiotic 1-81d-1s

    Flavocidin

    Virocidin

    Antibiotics from Actinomyces 1212 and 452-7

    Antibiotic F 416

    Cephalomycin

    Virusin 1609

    Luridin

    Antibiotic F 256

    Violarin

    Antivirubin

    Antiviral Agent from Nocardia Formica

    Cardicin

    J . Antibiotics With Antitumour Activity

    Azaserine

    6-Diazo-5-Oxo-L-Norleucine, syn. DON

    Diazomycins, syn. Duazomycins

    Sarkomycin

    Actinomycins

    Lyomycin

    Actinoleukin

    Questiomycins A and Β

    Mitomycin

    Labilomycin

    Formycin

    Olivomycin

    Ayamycin

    Mitiromycin

    Porfiromycin

    Roseolic Acid

    Cellocidin

    Antitumour Substance from Streptomyces sp, 1418

    Pillaromycin

    Antibiotic 6270

    Alazopeptin

    Substance 289

    Pluramycin

    Taitomycin

    Melanomycin

    Gancidin

    Antibiotic BA-180265

    Carzinophilin

    Streptonigrin

    Minomycin

    Sulfocidin

    Sparsomycin

    Desertomycin

    Actinobolin

    Carzinocidin

    Mutomycin

    Cervicarcin

    Daunomycin, Rubidomycin

    Chromomycins

    Aurantin

    Actinoxanthin

    Enomycin

    Pactamycin

    Caryomycin

    Carzinostatin

    Raromycin

    Antitumour Antibiotic from Streptomyces Sp. 1683

    Antitumour Antibiotic M-770

    Actinoflocin

    Triostins

    Actinin, syn. Mycetin

    Marinamycin

    Showdomycin




Product details

  • No. of pages: 1164
  • Language: English
  • Copyright: © Pergamon 1967
  • Published: January 1, 1967
  • Imprint: Pergamon
  • eBook ISBN: 9781483223056

About the Authors

Tadeusz Korzybski

Zuzanna Kowszyk-Gindifer

Wlodzimierz Kurylowicz

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