Antibiotics - 1st Edition - ISBN: 9781483198026, 9781483223056

Antibiotics

1st Edition

Origin, Nature and Properties

Authors: Tadeusz Korzybski Zuzanna Kowszyk-Gindifer Wlodzimierz Kurylowicz
eBook ISBN: 9781483223056
Imprint: Pergamon
Published Date: 1st January 1967
Page Count: 1164
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Description

Antibiotics: Origin, Nature and Properties, Volume I is a systematic coverage of the sources, varieties, and properties of the antibiotics. This book is organized into two main parts encompassing 13 chapters. This book considers the antibiotics according to their sources. It describes the antibiotics produced by bacteria, Actinomycetes,Fungi imperfecti, Basidiomycetes, algae, lichens and green plants, and those from animal sources. This group of antibiotics includes, streptomycin, the tetracyclines, chloromycetin, the macrolide family of compounds of which erythromycin, magnamycin and spiramycin are members, and the antifungal polyene compounds. The members of each group are arranged according to their chemical and biological similarity. Sections on each antibiotic present complete information, including the name, description of the producing strains, composition of the media, methods of culture, isolation and purification of the antibiotic principle, its physical and chemical properties, antibiotic spectrum, toxicity for laboratory animals, results of treatment of experimental infections, and possible clinical applications. This book is of value to researchers and workers in various medical fields.

Table of Contents


Foreword

Introduction

Part I Antibiotics Produced by Micro-Organisms of the Order Euhacteriales

A. Antibiotics Isolated from the Genus Pseudomonas (Pseudomonadaceae)

Pyocyanine

Hemipyocyanine

Antibiotic Ρχ

Chlororaphin

Antibiotic Substances from Pseudomonas Aeruginosa

Pyoluteorin

Comirin

Pyolipic Acid

Pyocyanase

Pyoklastin

Viscosin

B. Antibiotics Isolated from the Genus Micrococcus (Micrococcaceae), Streptococcus, Diplococcus (Lactobacteriaceae), Chromobacterium, Escherichia and Proteus (Enterobacteriaceae)

Micrococcin

Nisin

Diplococcin

Streptostasin

Diplomycin

Mycobactocidin

Lactobacillin

Prodigiosin

Iodinin

Violacein

Marcescin

Xerosin

Coliformin

Colicines

Protaptins

Antibiotic from Escherichia Coli

Toxoflavin

C. Antibiotics Isolated from the Genus Bacillus (Bacillaceae)

Gramicidin S

Gramicidin, Tyrocidine, Tyrothricin

Gramicidin J

Bacitracin, syn. Ayfivin

Subtilin

Licheniformins

Polymyxins—Aerosporin, Bacillosporin, Circulins

Colistin, syn. Colimycin

Alvein

Bacilipin, Bacilysin

Bacillin

Globicin

Brevin

Brevolin

Bacimethrin

Edein

Antifungal Antibiotics Produced by Micro-Organisms of Genus Bacillus

Bacillomyxin

Bacillomycin

Antifungal Antibiotics from Bacillus Subtilis

Fungocin

Eumycin

Toximycin

Antifungal Agents from Bacillus Subtilis

Datemycin

Fungistatin, syn. Antibiotic XG

Mycosubtilin

Rhizobacidin

Simplexin

Polypeptin

Laterosporins

Fluvomycin, syn. Efsiomycin, Vivicil, Riomycin

Cerein

Tetaine

Pumilin

Subtenolin

Megacine

Xanthellin

Esperin

Iturine

Neocidin

Obutin

Biocerin

Endosubtilysine

Colistatin

Subtilysine, Analysine

Mycobacillin

Petrin

Nigrin

Antibacterial Substance Produced by Bacillus Natto

Trypanotoxin

Polysaccharidases

Antibiotic Substances from Myxococcaceae

Part II Antibiotics Produced By Micro-Organisms of the Order Actinomycetales

A. Macrolides

Picromycin

Argomycin

Methymycin

Neomethymycin

Amaromycin

Narbomycin

Oleandomycin, syn. Antibiotic P.A. 105, Matromycin

Erythromycin, syn. Ilotycin

Magnamycin, syn. Carbomycin, Antibiotic M-4209

Spiramycin, syn. Foromacidin, Rovamycin

Angolamycin

Lankamycin and Lankacidin

Chalcomycin, syn. Miconomycin

Substance 446

Mesenterin

Griseomycin, syn. Lomycin

Miamycin

Albomycetin

Leucomycin

Tertiomycin

Macrolide-Type Antibiotics: PA-108, PA-133A, PA-133B and PA-148

Tylosin

Macrocin

Proactinomycins

Acumycin

Cirramycin

B. Antibiotics Active Against Grampositive Micro-Organisms

Granaticin

Novobiocin, syn. Cathomycin, Cathocin, Streptonivicin, Albamycin, Antibiotic P.A.93, Cardelmycin

Rifamycins

Amicetin, syn. Sacromycin, Allomycin

Amicetin Β

Bamicetin

Plicacetin

Actinorhodin

Thermorubin

Antibiotic BA-6903

Indolmycin, Syn. Antibiotic PA-155 A

Althiomycin

Teomycic Acid

Totomycin

Nitrosporin

Ramnacin

Resistomycin

Exfoliatin

Sulfactin

Celesticetin

Lincomycin

Proceomycin

Aureolic Acid

Monazomycin

Aburamycin

Antibiotic Μ 5-18903

Antibiotic 24-10

Nocardianin

Rubidin

Julymycin B-II

Rubromycin

Sarcidin

Bundlins A and Β

Pulvomycin

Vancomycin

Frenolicin

Antibiotic K-288

Thermoviridin

Actiduins

Ristocetin, syn. Spontin

Vinacetin

Antibiotic L.A. 7017

Monamycin

Erigrisin

Elaiophylin

Melanosporin

Antibiotic SKCC 1377

Antibiotic J4

Antibiotic 1943

Bandamycin

Actinoidin

Cladomycin

Actinomycelin

Coelicolorin

Colinomycin

Fuscomycin

Antibiotic A 116

Streptin

Thermomycin

Antibiotic 19A

Sax 10 Substance

Antibiotic from Streptomyces Sp. 340

Raisnomycin

Antibiotic 721

Microsin

Antibiotic Κ 125a

Mycetin

Phthiocol

C. Polypeptide Antibiotics

Echinomycin

Quinomycins

Bottromycin

Griseoviridin and Viridogrisein, syn. Etamycin

Valinomycin

Leucopeptin

Amidomycin

Sideromycins

Succinimycin

Nocardamine

Grisein

Albomycin

Danomycin

Antibiotic LA 5352 and LA 5937

Staphylomycin, syn. Antibiotic 899, Virginiamycin

Streptogramin

Mikamycins

Antibiotic PA 114

Ostreogricin, syn. Antibiotic E-129

Pristinamycin, syn. Antibiotic 7293 R.P., Pyostacin

Duramycin

Telomycin

Crystallomycin

Amphomycin

Stendomycin

Zaomycin

Aspartocin

Glumamycin

Cinnamycin

Thiostrepton

Siomycin

Bryamycin

Substance A-59 and A-59B

Viomycin

Capreomycin, syn. Capromycin

Ilamycins

Rufomycins

Vinactins

Actinogan

Peptimycin

Antibiotic 1415

Cranomycin

Phytoactin and Phytostreptin

Phleomycin

Antibiotic from Actinomyces 1-21

Antibiotic from Actinomyces Strain 300

Evericin

Aminomycin

Antibiotic from Streptomyces Sp. (Sackman)

Antibiotic 6613

Micromonosporin

Antibiotic X-5079C

Actinomycetin

Geminimycin

Grizin, syn. Grizemin, Antibiotic IEM I

Mycomycetin

Lysozyme of Actinomycetes

Antibiotic BU 306

Antibiotic BU 271

D. The Broad-Spectrum Antibiotics

Chloramphenicol, syn. Chloromycetin

Tetracyclines

Chlortetracychne, syn. Aureomycin, Duomycin

Oxytetracycline, syn. Terramycin

Tetracycline, syn. Achromycin, Terracin

Tetracycline Derivatives

Synthesis of Tetracyclines

Biosynthesis of Tetracyclines

Chelocardin

Rhodomycins

Cinerubins

Pyrromycin

Rutilantin

Quinocyclines

Streptomycin

Hydroxystreptomycin, syn. Reticulin

Antibiotic U-12898, syn. Bluensomycin

Glebomycin

Trehalosamine

Hygromycin

Hygromycin Β

Homomycin

Antibiotic 1703-18 Β

Actinospectacin

Streptothricin

Antibiotic A 4788

Streptohn

Geomycin

Roseothricin

Racemomycins

Lavendulin

Actinorubin

Pleocidin

Amycin

Polymycin

Mycothricin

Antibiotic 587/13

Antibiotic A 20

Antibiotic Ax 18

Antibiotic 136

Antibiotic 156

Phytobacteriomvcin

Antibiotic EI5

Neomycins

Paromomycin, syn. Humatin

Monomycin

Zygomycins

Kanamycins

Eurymycin

Colimycin

Antibiotic 956

Antibiotic from Streptomyces Sp. (Mukherjee)

Roseomycin

Novomycin

Flavomycin

Soframycin, syn. Framycetin

Antibiotic A 6

Mycerin

Dextromycin

Catenulin

Aminosidin, syn. Crestomycin, Antibiotic 1600, Antibiotic F.I. 5853, Farmiglucin

Hydroxymycin, Syn. Antibiotic 4915

Antibiotic GB/229

Antibiotic Ac 3

Azomycin

Antibiotic HA-9

Thiolutin

Isobutyrylpyrrothine

Aureothricin

Holomycin

1,6-Dihydroxyphenazine

N-Acetyltyramine

Thioaurin

Thiomycin

Bleomycin

Griseolutein

Chartreusin

Primycin

Mycospocidin

Litmocidin

Mycorhodin

Luteomycin

Xanthomycins

Levomycin

Streptozotocin

Ractinomycin

Streptolydigin

Azalomycins Β and F

Nigericin

Cyanomycin

Matamycin

Violacetin

Xanthothricin

Emimycin

Antibiotic from Streptomyces Tanashiensis

Ruticin

Streptocardin

Rhodocidin

Flaveolin

Antibiotic from Streptomyces Sp. (Rolland)

Antibiotic 10 CM

Antibiotic from Actinomyces Flavus Strain 2

Antibiotics from Streptomyces Sp. 1900-IAUR

Phalamycin

Actinonin

Speciomycin

Miramycin

Enteromycin

Fluorin

Griseococcin

Gougerotin

Longisporin

Monamycin

Microcins

Actinolysin

Primocarcin

Nocardorubin

Neonocardin

E. Antibiotics Active Against Acid-Fast Bacilli

Acetomycin

Cycloserine, syn. Seromycin, Oxamycin, Antibiotic P.A. 94, Orientomycin, D-4-Amino-3-Isoxazolidone

O-Carbamyl-D-Serine

Actithiazic Acid, Syn. Mycobacidin, Acidomycin

Elaiomycin

Mycomycin, Isomycomycin

Antibiotic HON

Tubermycins

Tuberin

Bovinocidin

Tubercidin

Angustmycins

Psicofuranine

Antitumour Antibiotic from Helminthosporium

Grisamine

Pyridomycin, syn. Antituberculous Antibiotic

Streptovaricin, syn. Dalacin

Griseoflavin

Antibiotic WR 3/17

Antibiotic D-13

Anti-Phlei Factor

Anti-Smegmatis Factor

Phthiomycin

Antituberculous Substance From Streptomyces Strain

Nocardin

Globisporin

Antibiotics of Mycobacteria

F. Antifungal Antibiotics (Polyenes)

Tetraene Antibiotics

Fungicidin, syn. Nystatin, Mycostatin

Pimaricin

Tennecetin

Antifungal Antibiotic from Streptomyces 3569, syn. Antimycoin

Rimocidin

Chromin

Protocidine

Antifungal Antibiotic from a Strain of Streptomyces Sp. Ac2 435

Tetrin

Lucensomycin, syn. Etruscomycin, Antibiotic 1163 F.I.

Sistomycosin

Antifungal Antibiotics J4 A and J4 Β

Antifungal Antibiotic 7071 R.P.

Antibiotic PA 86

Albofungin

Antifungal Antibiotic PA 166

Unamycins

Pentaene Antibiotics

Eurocidin

Fungichromin, Fungichromatin

Filipin

Antibiotic A 246, syn. Lagosin

Pentamycin

Moldcidins

Cabicidine

Capacidin

Aliomycin

Antifungal Antibiotic PA 153

Antifungal Antibiotic A 228

Hexaene Antibiotics

Cryptocidin

Mediocidin

Fradicin

Mycelin

Antifungal Antibiotic 1587-Z 2

Flavacid

Endomycin

Helixins

Substance D

Heptaene Antibiotics

Amphotericin

Candidin, Candidinin, Candidoin

Candimycin

Candicidin

Ascosin

Trichomycin

Perimycin, syn. Antibiotic 1968, Antibiotic NC-1968

Hamycin

Antibiotic 26/1, syn. Levorin

Antibiotic 757

Antibiotic F-17-C

Antifungal Antibiotic AYF

Antifungal Antibiotic 1645

Antifungal Antibiotic PA 150

Ayfactin

Aureofacin

Antifungal Antibiotics from Streptomyces Sp. 1033 and 1038

Grubilin

Antifungal Antibiotic

G. Antifungal (Non-Polyene) Antibiotics

Cycloheximide, syn, Actidione

Viractin

Protomycin

Antitumour Substance E-73

Streptovitacins

Inactone and Isoactidiones

Actiphenol

Streptimidone

Niromycins

Naramycin

Niger Factor

Nonactin

Antibiotic FH 3582, syn. Werramycin

Antibiotic SQ 15859

Antimycin, syn. Antibiotic 720 A, Virosin, Antipiricullin, Antibiotic from Streptomyces Kitazawaensis

Blastmycin

Toyocamycin

Vengicid

Fermicidin

Ascomycin

Hygroscopin

Monilin

Antibiotic PA 132

Mycoticin

Cerevioccidin

Anthelmycin

Mycolutein

Oligomycin

Antibiotic A 272

Venturicidin

Antibiotics from Streptomyces X 206, X 464 and X 537 A

Humidin

Hygrostatin

Lustericin

Dermostatin

Musarin

Eumycetin

Blasticidins

Blasticidin S

Pathocidin

Septacidin

Cytomycin

Cellostatin

Flavensomycin

Alomycin

Euhcin

Seligocidin

Alboverticiuin

Flavofungin

Xanthicin

Antifungal Substance from a Streptomycete (Thirumalachar)

Cacaomycetin

Moldin

Actinon

Camphomycin

Mycelin

Mycerin (Arai)

Phaeophacin

Rotaventin

Antibiotic Β 74

Bulging Factor

Antibiotic P-9

Antifungal Antibiotic S-39

Antibiotic A 67

Antibiotic 30-10

Vulgarin

Amylocyanin

H. Antibiotics Active Against Protozoa

Puromycin, syn. Stylomycin

Netropsin, syn. Sinanomycin, Congocidine Antibiotic 1142, Antibiotic T-1384

Distamycin A

Antibiotic 2814 A, 2814 P, 2814 Κ

Antibiotic IA 887

Nucleocidin

Anisomycin, syn. Flagecidin

Borrelidin

Antitoxoplasmic Substance No. 534

Streptocin

Antibiotic 7.080 R.P.

Antibiotic X-948

Antibiotic X-1008

Antibiotic PA 128

Ascaricidin

I. Antibiotics Active Against Plant and Animal Viruses

Nybomycin

Myxoviromycin

Amidinomycin

Chrysomycin

Aklavin

Phagolessin A-58

Phagostatin

Phagomycin

Phagocidin

Grasseriomycin

Abikoviromycin, syn. Latumcidin

Achromoviromycin

Ehrlichin

Antibiotic Ε 300

Hehomycin

Cerulomycin

Antibiotic F 43

Antibiotic 1-81d-1s

Flavocidin

Virocidin

Antibiotics from Actinomyces 1212 and 452-7

Antibiotic F 416

Cephalomycin

Virusin 1609

Luridin

Antibiotic F 256

Violarin

Antivirubin

Antiviral Agent from Nocardia Formica

Cardicin

J . Antibiotics With Antitumour Activity

Azaserine

6-Diazo-5-Oxo-L-Norleucine, syn. DON

Diazomycins, syn. Duazomycins

Sarkomycin

Actinomycins

Lyomycin

Actinoleukin

Questiomycins A and Β

Mitomycin

Labilomycin

Formycin

Olivomycin

Ayamycin

Mitiromycin

Porfiromycin

Roseolic Acid

Cellocidin

Antitumour Substance from Streptomyces sp, 1418

Pillaromycin

Antibiotic 6270

Alazopeptin

Substance 289

Pluramycin

Taitomycin

Melanomycin

Gancidin

Antibiotic BA-180265

Carzinophilin

Streptonigrin

Minomycin

Sulfocidin

Sparsomycin

Desertomycin

Actinobolin

Carzinocidin

Mutomycin

Cervicarcin

Daunomycin, Rubidomycin

Chromomycins

Aurantin

Actinoxanthin

Enomycin

Pactamycin

Caryomycin

Carzinostatin

Raromycin

Antitumour Antibiotic from Streptomyces Sp. 1683

Antitumour Antibiotic M-770

Actinoflocin

Triostins

Actinin, syn. Mycetin

Marinamycin

Showdomycin




Details

No. of pages:
1164
Language:
English
Copyright:
© Pergamon 1967
Published:
Imprint:
Pergamon
eBook ISBN:
9781483223056

About the Author

Tadeusz Korzybski

Zuzanna Kowszyk-Gindifer

Wlodzimierz Kurylowicz