Anti-inflammatory Agents Part I

Chemistry and Pharmacology

1st Edition - January 1, 1974
Editor: Robert Scherrer
Language: English
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 5 0 1 5 - 6

Medicinal Chemistry: A Series of Monographs, Volume 13–I explores the development in the treatment of some severely debilitating chronic inflammatory diseases, including arthritis,… Read more

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Medicinal Chemistry: A Series of Monographs, Volume 13–I explores the development in the treatment of some severely debilitating chronic inflammatory diseases, including arthritis, gout, rheumatoid arthritis, osteoarthritis, systemic lupus erythematosus, psoriasis, conjunctivitis, episcleritis, and uveitis. This volume examines the anti-inflammatory drugs used to alter the inflammatory response in diseases of unknown cause. This book is comprised of two parts encompassing 11 chapters. Part I discusses the factors that cause the inflammation and explores the interaction of these causative agents with those therapies found to be clinically effective. This text also presents an illustrative classification of some debilitating inflammatory conditions and the available therapy. Part II explores the nonsteroidal anti-inflammatory agents that are peripheral analgesics and anti-pyretic. Other chapters review colchicine and allopurinol as anti-inflammatory drugs for gout. Finally, this volume ends with a discussion on the anti-inflammatory activity of some proteolytic enzymes of vegetable, animal, fungal, and bacterial origin. Physicians, chemists, and experimental biologists will find this book extremely useful.

List of Contributors

Preface

Contents of Volume II

Introduction

Selected Reviews Dealing with Antiinflammatory Drugs

Part I Inflammatory Diseases

Chapter 1 Some Inflammatory Diseases in Man and Their Current Therapy

I. Introduction

II. Gout

III. The Rheumatoid Variants

IV. Rheumatoid Arthritis

V. Systemic Lupus Erythematosus

VI. Renal Transplantation

VII. Osteoarthritis (Degenerative Joint Disease)

VIII. Psoriasis

IX. Other Skin Diseases

X. Conjunctivitis, Episcleritis, and Uveitis

References

Part II Preparation, Physical and Chemical Properties, and Structure—Activity Relationships

Chapter 2 Introduction to the Chemistry of Antiinflammatory and Antiarthritic Agents

I. Scope of These Chapters

II. Chemical and Pharmacological Classes; Interaction Potential

III. Assessment of Pharmacological Data in the Evaluation of Literature Reports

IV. Classical Nonsteroidal Antiinflammatory Agents

V. Receptor Site for Classical Antiinflammatory Agents

VI. Latent Antiinflammatory Agents

VII. Two Nonclassical Antiinflammatory Series

VIII. Goals of Future Research

References

Chapter 3 Aryl- and Heteroarylcarboxylic Acids

I. N-Arylanthranilic Acids

II. Heterocyclic Isosteres of N-Arylanthranilic Acids

III. Homologs of N-Arylanthranilic Acids and Heterocyclic Isosteres

IV. Fixed-Planar Arylcarboxylic Acids

V. The Antiinflammatory Receptor Site

VI. Salicylic Acids

VII. σ-Hydroxy"tricycle"carboxylic Acids

VIII. Miscellaneous Carboxylic Acids

References

Chapter 4 Aryl- and Heteroarylalkanoic Acids and Related Compounds

I. Introduction

II. Phenylacetic Acids

III. 3-Phenylpropionic Acids

IV. 4-Phenylbutyric Acids

V. Naphthaleneacetic Acids

VI. Indancarboxylic Acids

VII. 1,2,3,4-Tetrahydro-l-naphthoic Acids

VIII. Indoleacetic Acids and Related Compounds

IX. Phenothiazine-2-Acetic Acids

X. Pyrrolealkanoic Acids

XI. Furanalkanoic Acids

XII. Oxazolepropionic Acids

XIII. Thiazoleacetic Acids

XIV. Tetrazolealkanoic Acids

XV. Overall Structure-Activity Relationships

XVI. Conclusion

XVII. Addendum

References

Chapter 5 Enolic Acids with Antiinflammatory Activity

I. Introduction

II. Pyrazolidinediones

III. Other ß-Diketones (Nonpyrazolidinediones)

IV. ß-Sulfonylketones

V. Concluding Remarks

References

Chapter 6 Sulfonamides with Antiinflammatory Activity

I. Introduction

II. Fluoroalkanesulfonanilides

III. Other Sulfonamides

References

Chapter 7 Nonacidic Antiarthritic Agents and the Search for New Classes of Agents

I. Introduction

II. The Search for New Structural Types

III. Nonacidic Antiinflammatory Agents

IV. Clinical Antirheumatic Studies

References

Chapter 8 Design and Laboratory Evaluation of Gold Compounds as Antiinflammatory Agents

I. Introduction

II. Laboratory Evaluation of Gold Compounds

III. Design of Chrysotherapeutic Agents

IV. Pharmacology of Orally Absorbed Gold Compounds

V. Summary

References

Chapter 9 Antiinflammatory Steroids

I. Introduction

II. Evolution of Therapeutic Agents

III. Methods for Evaluating Corticosteroids

IV. Structure-Activity Relationships

V. New Approaches to Corticosteroid Therapy

VI. Conclusions

References

Chapter 10 Colchicine and Allopurinol

I. Introduction

II. Gout

III. Colchicine

IV. Allopurinol

V. Appendix

VI. Addendum

References

Chapter 11 Antiinflammatory Proteins and Peptides

I. Introduction

II. Adrenocorticotropic Hormones (ACTH's)

III. Enzymes as Therapy for Inflammation

IV. Other Antiinflammatory Proteins

V. Chalones: Natural Antiproliferative Agents

References

Author Index

Subject Index