Anti-inflammatory Agents Part I

Anti-inflammatory Agents Part I

Chemistry and Pharmacology

1st Edition - January 1, 1974

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  • Editor: Robert Scherrer
  • eBook ISBN: 9780323150156

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Description

Medicinal Chemistry: A Series of Monographs, Volume 13–I explores the development in the treatment of some severely debilitating chronic inflammatory diseases, including arthritis, gout, rheumatoid arthritis, osteoarthritis, systemic lupus erythematosus, psoriasis, conjunctivitis, episcleritis, and uveitis. This volume examines the anti-inflammatory drugs used to alter the inflammatory response in diseases of unknown cause. This book is comprised of two parts encompassing 11 chapters. Part I discusses the factors that cause the inflammation and explores the interaction of these causative agents with those therapies found to be clinically effective. This text also presents an illustrative classification of some debilitating inflammatory conditions and the available therapy. Part II explores the nonsteroidal anti-inflammatory agents that are peripheral analgesics and anti-pyretic. Other chapters review colchicine and allopurinol as anti-inflammatory drugs for gout. Finally, this volume ends with a discussion on the anti-inflammatory activity of some proteolytic enzymes of vegetable, animal, fungal, and bacterial origin. Physicians, chemists, and experimental biologists will find this book extremely useful.

Table of Contents


  • List of Contributors

    Preface

    Contents of Volume II

    Introduction

    Selected Reviews Dealing with Antiinflammatory Drugs

    Part I Inflammatory Diseases

    Chapter 1 Some Inflammatory Diseases in Man and Their Current Therapy

    I. Introduction

    II. Gout

    III. The Rheumatoid Variants

    IV. Rheumatoid Arthritis

    V. Systemic Lupus Erythematosus

    VI. Renal Transplantation

    VII. Osteoarthritis (Degenerative Joint Disease)

    VIII. Psoriasis

    IX. Other Skin Diseases

    X. Conjunctivitis, Episcleritis, and Uveitis

    References

    Part II Preparation, Physical and Chemical Properties, and Structure—Activity Relationships

    Chapter 2 Introduction to the Chemistry of Antiinflammatory and Antiarthritic Agents

    I. Scope of These Chapters

    II. Chemical and Pharmacological Classes; Interaction Potential

    III. Assessment of Pharmacological Data in the Evaluation of Literature Reports

    IV. Classical Nonsteroidal Antiinflammatory Agents

    V. Receptor Site for Classical Antiinflammatory Agents

    VI. Latent Antiinflammatory Agents

    VII. Two Nonclassical Antiinflammatory Series

    VIII. Goals of Future Research

    References

    Chapter 3 Aryl- and Heteroarylcarboxylic Acids

    I. N-Arylanthranilic Acids

    II. Heterocyclic Isosteres of N-Arylanthranilic Acids

    III. Homologs of N-Arylanthranilic Acids and Heterocyclic Isosteres

    IV. Fixed-Planar Arylcarboxylic Acids

    V. The Antiinflammatory Receptor Site

    VI. Salicylic Acids

    VII. σ-Hydroxy"tricycle"carboxylic Acids

    VIII. Miscellaneous Carboxylic Acids

    References

    Chapter 4 Aryl- and Heteroarylalkanoic Acids and Related Compounds

    I. Introduction

    II. Phenylacetic Acids

    III. 3-Phenylpropionic Acids

    IV. 4-Phenylbutyric Acids

    V. Naphthaleneacetic Acids

    VI. Indancarboxylic Acids

    VII. 1,2,3,4-Tetrahydro-l-naphthoic Acids

    VIII. Indoleacetic Acids and Related Compounds

    IX. Phenothiazine-2-Acetic Acids

    X. Pyrrolealkanoic Acids

    XI. Furanalkanoic Acids

    XII. Oxazolepropionic Acids

    XIII. Thiazoleacetic Acids

    XIV. Tetrazolealkanoic Acids

    XV. Overall Structure-Activity Relationships

    XVI. Conclusion

    XVII. Addendum

    References

    Chapter 5 Enolic Acids with Antiinflammatory Activity

    I. Introduction

    II. Pyrazolidinediones

    III. Other ß-Diketones (Nonpyrazolidinediones)

    IV. ß-Sulfonylketones

    V. Concluding Remarks

    References

    Chapter 6 Sulfonamides with Antiinflammatory Activity

    I. Introduction

    II. Fluoroalkanesulfonanilides

    III. Other Sulfonamides

    References

    Chapter 7 Nonacidic Antiarthritic Agents and the Search for New Classes of Agents

    I. Introduction

    II. The Search for New Structural Types

    III. Nonacidic Antiinflammatory Agents

    IV. Clinical Antirheumatic Studies

    References

    Chapter 8 Design and Laboratory Evaluation of Gold Compounds as Antiinflammatory Agents

    I. Introduction

    II. Laboratory Evaluation of Gold Compounds

    III. Design of Chrysotherapeutic Agents

    IV. Pharmacology of Orally Absorbed Gold Compounds

    V. Summary

    References

    Chapter 9 Antiinflammatory Steroids

    I. Introduction

    II. Evolution of Therapeutic Agents

    III. Methods for Evaluating Corticosteroids

    IV. Structure-Activity Relationships

    V. New Approaches to Corticosteroid Therapy

    VI. Conclusions

    References

    Chapter 10 Colchicine and Allopurinol

    I. Introduction

    II. Gout

    III. Colchicine

    IV. Allopurinol

    V. Appendix

    VI. Addendum

    References

    Chapter 11 Antiinflammatory Proteins and Peptides

    I. Introduction

    II. Adrenocorticotropic Hormones (ACTH's)

    III. Enzymes as Therapy for Inflammation

    IV. Other Antiinflammatory Proteins

    V. Chalones: Natural Antiproliferative Agents

    References

    Author Index

    Subject Index


Product details

  • No. of pages: 442
  • Language: English
  • Copyright: © Academic Press 1974
  • Published: January 1, 1974
  • Imprint: Academic Press
  • eBook ISBN: 9780323150156

About the Editor

Robert Scherrer

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