Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging

Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging

1st Edition - June 3, 2022

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  • Editors: Sandeep Singh, Chih Lin, Shailendra Mishra
  • Paperback ISBN: 9780323902359

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Description

Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging is a comprehensive and timely book on all aspects of anti-aging strategies. The book provides comprehensive, foundational knowledge on the mechanisms of aging and current anti-aging strategies and approaches developed. Aging research has experienced an unprecedented advance over recent years with the discovery that the rate of aging is determined, at least to some extent, mainly by our genetics and modulated by environmental factors. The hallmarks of aging describe the molecular and cellular processes that govern biological aging and their variation in individuals.

Key Features

  • Covers different aspects of anti-aging research, from foundational knowledge to future perspectives
  • Provides understanding on the different hallmarks of aging and how they can be applied in the development of anti-aging drugs
  • Discusses various anti-aging strategies, including telomerase reactivation, clearance of senescent cells, stem cell-based therapy, and others

Readership

Advanced undergraduate students and graduate students as well as researchers interested or working in various aspects of aging

Table of Contents

  • Preface

    1. The aging: introduction, theories, principles and future prospective
    Shabnam Shabir, Mahendra Pratap Singh

    2. Brief description of aging in different levels as cellular, tissues, and organs
    Anuradha Venkatakrishnan Chimata, Prajakta Deshpande, Amit Singh

    3. Brief about hallmarks of aging
    Josephine Esposto and Vyshnavy Balendra

    4. Overview of various anti-aging strategies
    Dhiraj Kumar and Faiyaz Ahmad

    5. Elimination of damaged cells-dependent anti-aging strategy
    Rayees Ahmad Naik, Vinodinee Dubey, Roshni Rajpoot, Debabrata Dash, Nidhi Gupta and Raj Kumar Koiri

    6. Telomerase reactivation for anti-aging
    TS Gopenath, Shreya Shreshtha and Kanthesh M. Basalingapa

    7. Epigenetic drugs based on anti-aging approach
    Tarun Minocha, Namrata Dwivedi, Chetan Panda, Anamika Misra, Barsha Baisakhi Nayak, Sanjeev Kumar Yadav, Hareram Birla and Sandeep K. Singh

    8. Activation of chaperons and proteolytic system: emerging methods for anti-aging drug development
    Neha Gogia, Victor Olmos, Fatema Haidery, Kimberly Luttik, Leon Tejwani, Janghoo Lim

    9. Dietary restriction and mTOR and IIS inhibition: the potential to anti-aging drug approach
    Sing-Hua Tsou

    10. Anti-Aging Drugs, Candidates, and Food Supplements- The journey so far
    Yodhaanjali JR, Rithwick Surya, Sumukha KC, Harini G, Gouri Deshpande, Chandan S,Raghu Ram Achar

    11. Role of AMPK and Sirtuins as anti-aging proteins
    Manjula Ramu, Sonali Vishal and Neha Gogia

    12. Mitophagy and Mitohormetics: promising anti- aging strategy
    Chih Li Lin

    13. Clearance of senescent cells: potent anti-aging approach
    Jacques Ferreira and Alex Deamer

    14. Stem cell-based therapy as antiaging prospective
    Sumaira Yusuf, Mahendra P. Singh

    15. Anti-inflammatory therapy as a game changer towards anti-aging
    Dr. Naveen Shivavedi, Anshul Shakya, Bedanta Bhattacharjee and Bhargab Deka

    16. Invertebrate model organisms for aging research
    Arvind Kumar Shukla, Andrew Scott and Edward Giniger

Product details

  • No. of pages: 320
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: June 3, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780323902359

About the Editors

Sandeep Singh

Sandeep Kumar Singh is the Founder President of Indian Scientific Education and Technology (ISET) Foundation. He is a well-trained neuroscientist with a strong background in Biochemistry and Biomedicine. He earned his Bachelor of Science (Biology) from University of Lucknow, India, in 2005 and Master of Science (Biotechnology) from CSJM University, India, in 2008. He was honored with Ph.D. degree in Biotechnology from the most prestigious institution, the “Capital of Knowledge” Banaras Hindu University, India, in the year 2015. His research interests are in neurodegenerative diseases, in particular Alzheimer’s disease. He has more than 9 years of experience in neuroscience research and has worked as Postdoctoral Scholar at Neurobiology Department, The University of Chicago, USA. He is currently working as Research Associate at Centre of Biomedical Research, Lucknow, India.

Affiliations and Expertise

Research Associate, Centre of Biomedical Research, India

Chih Lin

Chih-Li Lin is a Professor and Research Fellow of Chung Shan Medical University and Hospital, Taiwan. He obtained his Ph. D. degree in the Institute of Biochemistry and Molecular Biology from National Taiwan University Medical College in 2007. Lin completed his postdoctoral research on the dementia & Alzheimer’s disease in National Taiwan University Hospital, and then moved to Institute of Medicine, Chung Shan Medical University (Taiwan) in 2008 and has been promoted to Full Professor in 2019. His major interests are to understand the pathophysiological connections between brain aging and Alzheimer’s dementia, particularly studying molecular mechanisms of amyloid beta (Aβ)-induced neurotoxicity, and applications of induced pluripotent stem (iPS) cell technology. He is currently working to demonstrate that brain insulin resistance may play roles in neuronal aging features and contribute to pathogenesis of Alzheimer's disease, Dementia with Lewy Bodies (DLB), and type 2 diabetes-associated dementia.

Affiliations and Expertise

Professor and Research Fellow, Institute of Medicine, Chung Shan Medical University and Hospital, Taiwan, Province of China

Shailendra Mishra

Shailendra Kumar Mishra is co-founder of Indian Scientific Education and Technology (ISET) Foundation, a non-profit/non-governmental organization that persuades toward the science promotion. He is Molecular Human Genetics postgraduate, skilled in DNA Sequencing, Polymerase Chain Reaction (PCR), DNA & Plasmid isolation, Gel electrophoresis, Molecular hybridization, DNA elution from agarose gel, bacterial transformation, quantitation of DNA, DNA sequencing technique and versed in various diagnostic techniques. He did Master of Science in Molecular and Human Genetics from Jiwaji University, India, and research project from Banaras Hindu University, India. He has published his articles in some international and national journals such as Journal of Alzheimer’s Disease and Parkinsonism and Nature India. His major interest is to understand the aging process through molecular basis that could be beneficial to cure age-related diseases.

Affiliations and Expertise

Postdoc Research Fellow, Sichuan Agricultural University, India

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  • Shailendra M. Fri Feb 18 2022

    Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging

    Brilliant book to understand aging and anti-aging concept from basic to update research. This book also gives brief about hallmark of aging and elaborates how to tackle these aging process through robust anti-aging strategies.