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Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging - 1st Edition - ISBN: 9780323902359

Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging

1st Edition

Editors: Sandeep Singh Chih Lin Shailendra Mishra
Paperback ISBN: 9780323902359
Imprint: Academic Press
Published Date: 1st May 2022
Page Count: 320
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Description

Aging research has experienced an unprecedented advance over recent years with the discovery that the rate of aging is determined, at least to some extent, mainly by our genetics and modulated by environmental factors. The hallmarks of aging describe the molecular and cellular processes that govern biological aging and their variation in individuals.

Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging is a comprehensive and timely book on all aspects of anti-aging strategies, providing comprehensive foundational knowledge of the mechanisms of aging and current anti-aging strategies and approaches developed based on the hallmarks of aging.

Key Features

  • Covers different aspects of anti-aging research, from foundational knowledge to future perspectives
  • Provides an understanding of the different hallmarks of aging and how they can be applied in the development of anti-aging drugs
  • Discusses various anti-aging strategies, including telomerase reactivation, clearance of senescent cells, stem cell-based therapy, and others

Readership

Advanced undergraduate students and graduate students as well as researchers interested or working in various aspects of aging

Table of Contents

  1. The aging: introduction, theories, principles and future prospective
    2. Brief description about aging in different levels as cellular, tissues and organs
    3. Brief about hallmarks of aging
    4. Overview of various anti-aging strategies
    5. Elimination of damaged cells-dependent anti-aging strategy
    6. Telomerase reactivation for anti-aging
    7. Epigenetic drugs based on anti-aging approach
    8. Activation of chaperons and proteolytic system: emerging methods for anti-aging drug development
    9. Dietary restriction and mTOR and IIS inhibition: potential to anti-aging drug approach
    10. AMPK and sirtuins activation role in anti-aging
    11. Mitophagy and Mitohormetics: promising anti-aging strategy
    12. Clearance of senescent cells: potent anti-aging approach
    13. Stem cell-based therapy as antiaging prospective
    14. Anti-inflammatory therapy as a game changer towards anti-aging

Details

No. of pages:
320
Language:
English
Copyright:
© Academic Press 2022
Published:
1st May 2022
Imprint:
Academic Press
Paperback ISBN:
9780323902359

About the Editors

Sandeep Singh

Sandeep Kumar Singh is the Founder President of Indian Scientific Education and Technology (ISET) Foundation. He is a well-trained neuroscientist with a strong background in Biochemistry and Biomedicine. He earned his Bachelor of Science (Biology) from University of Lucknow, India, in 2005 and Master of Science (Biotechnology) from CSJM University, India, in 2008. He was honored with Ph.D. degree in Biotechnology from the most prestigious institution, the “Capital of Knowledge” Banaras Hindu University, India, in the year 2015. His research interests are in neurodegenerative diseases, in particular Alzheimer’s disease. He has more than 9 years of experience in neuroscience research and has worked as Postdoctoral Scholar at Neurobiology Department, The University of Chicago, USA. He is currently working as Research Associate at Centre of Biomedical Research, Lucknow, India.

Affiliations and Expertise

Research Associate, Centre of Biomedical Research, India

Chih Lin

Chih-Li Lin is a Professor and Research Fellow of Chung Shan Medical University and Hospital, Taiwan. He obtained his Ph. D. degree in the Institute of Biochemistry and Molecular Biology from National Taiwan University Medical College in 2007. Lin completed his postdoctoral research on the dementia & Alzheimer’s disease in National Taiwan University Hospital, and then moved to Institute of Medicine, Chung Shan Medical University (Taiwan) in 2008 and has been promoted to Full Professor in 2019. His major interests are to understand the pathophysiological connections between brain aging and Alzheimer’s dementia, particularly studying molecular mechanisms of amyloid beta (Aβ)-induced neurotoxicity, and applications of induced pluripotent stem (iPS) cell technology. He is currently working to demonstrate that brain insulin resistance may play roles in neuronal aging features and contribute to pathogenesis of Alzheimer's disease, Dementia with Lewy Bodies (DLB), and type 2 diabetes-associated dementia.

Affiliations and Expertise

Professor and Research Fellow, Institute of Medicine, Chung Shan Medical University and Hospital, Taiwan, Province of China

Shailendra Mishra

Shailendra Kumar Mishra is co-founder of Indian Scientific Education and Technology (ISET) Foundation, a non-profit/non-governmental organization that persuades toward the science promotion. He is Molecular Human Genetics postgraduate, skilled in DNA Sequencing, Polymerase Chain Reaction (PCR), DNA & Plasmid isolation, Gel electrophoresis, Molecular hybridization, DNA elution from agarose gel, bacterial transformation, quantitation of DNA, DNA sequencing technique and versed in various diagnostic techniques. He did Master of Science in Molecular and Human Genetics from Jiwaji University, India, and research project from Banaras Hindu University, India. He has published his articles in some international and national journals such as Journal of Alzheimer’s Disease and Parkinsonism and Nature India. His major interest is to understand the aging process through molecular basis that could be beneficial to cure age-related diseases.

Affiliations and Expertise

Postdoc Research Fellow, Sichuan Agricultural University, India

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