Anorexia - 1st Edition - ISBN: 9780124104730, 9780124104808

Anorexia, Volume 92

1st Edition

Serial Editors: Gerald Litwack
eBook ISBN: 9780124104808
Hardcover ISBN: 9780124104730
Imprint: Academic Press
Published Date: 1st May 2013
Page Count: 392
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Table of Contents

Former Editors



Chapter One. Novel Neuropeptides in the Control of Food Intake

1 Introduction

2 Neuronostatin

3 Nesfatin-1

4 Conclusions


Chapter Two. Anorexia and Hypothalamic Degeneration

1 Introduction

2 The anx/anx Mouse

3 General Aspects of Mechanisms Underlying Weight Disturbances

4 Neurodegeneration and Mitochondrial Dysfunction Related to Eating Disorders in Humans

5 Conclusions and Future Directions



Chapter Three. The Role of Ghrelin in Anorexia–Cachexia Syndromes

1 Introduction

2 Discovery of Ghrelin

3 Ghrelin, GHS-R1a, and GOAT

4 Mechanisms of Action of Ghrelin

5 Ghrelin and Sarcopenia of Aging

6 Ghrelin and Cancer Cachexia

7 Ghrelin and COPD-Induced Cachexia

8 Ghrelin and Anorexia Nervosa

9 Ghrelin and CHF-Induced Cachexia

10 Ghrelin and ESRD

11 AIDS-Associated Cachexia

12 RA-Associated Cachexia

13 Conclusions



Chapter Four. Ghrelin Gene Variants and Eating Disorders

1 Introduction

2 Ghrelin Signaling System

3 Physiological Functions of Ghrelin

4 Ghrelin and Eating Disorders

5 Ghrelin Gene Variants and Eating Disorders

6 Association of Ghrelin Polymorphisms with Anthropometry and Eating Pathology in Young Women

7 Association of Ghrelin Polymorphisms with Changes in Eating Disorder Phenotypes

8 Conclusions


Chapter Five. Steroid Metabolism and Excretion in Anorexia Nervosa

1 Introduction

2 Steroid Metabolism in Health

3 Steroid Metabolism in AN

4 Steroid Excretion in AN

5 Effects of Refeeding

6 Conclusions



Chapter Six. Anorexia Nervosa and Estrogen Receptors

1 Introduction

2 Anorexia Nervosa

3 Estrogens and Estrogen Receptors and Pathways

4 Estrogen and Anorexia

5 Human Genetics of Estrogen Pathway in Anorexia Nervosa

6 Conclusions


Chapter Seven. Cannabinoid Receptors and Cholecystokinin in Feeding Inhibition

1 Introduction: Peripheral Regulation of Food Intake: A Place for Endocannabinoids and Cholecystokinin

2 The Endocannabinoids and Feeding Regulation

3 CCK and Feeding Regulation

4 Interactions Between CCK and Endocannabinoid Receptors in the Regulation of Feeding

5 Conclusions and Clinical Relevance



Chapter Eight. Treatment of Cachexia

1 Introduction

2 Molecular Mediators of Cachexia

3 Peripheral and Central Appetite Regulation

4 Cancer Cachexia

5 Cardiac Cachexia

6 Renal Cachexia

7 Other Cachexia

8 Summary of Treatment Effects

9 Future Directions


Chapter Nine. The Influence of Estrogen Therapies on Bone Mineral Density in Premenopausal Women with Anorexia Nervosa and Amenorrhea

1 Introduction

2 Estrogen Therapy and Bone Mass

3 Potential Clinical Drawbacks of Estrogen Therapy for Patients with AN

4 Influence of Oral Contraceptives on Bone Mineral Density

5 Influence of Hormone Replacement Therapy on Bone Mineral Density

6 The Role of Insulin-Like Growth Factor 1 and Estrogen on Bone Mineral Density

7 Implications


Chapter Ten. Clinical and Hormonal Variables Related to Bone Mass Loss in Anorexia Nervosa Patients

1 Introduction

2 Materials and Methods

3 Results

4 Discussion




Chapter Eleven. Mechanism-Based Therapeutic Approaches to Cachexia

1 Introduction

2 Body and Tissue Wasting

3 Anorexia

4 Inflammation

5 Tissue Wasting in Cachexia: Hypoanabolism or Hypercatabolism?

6 From Mechanistic Alterations to Therapeutic Strategies

7 Nutritional Interventions

8 Anti-Inflammatory Strategies

9 Inhibition of Cytokine Production

10 Interference with Cytokine-Receptor Interaction

11 Strategies to Correct Metabolic Alterations

12 Conclusions


Chapter Twelve. Cisplatin-Induced Anorexia and Ghrelin

1 Introduction

2 Cisplatin-Induced Overproduction of 5-HT

3 Cisplatin, 5-HT-Induced Ghrelin Regulation

4 Treatment of Ghrelin- and Ghrelin Enhancer-Based, Cisplatin-Caused Dyspepsia

5 Conclusion


Chapter Thirteen. Anorexia of Aging

1 Introduction

2 Animal Studies

3 Human Studies

4 Anorexia of Aging May Result from the Imbalance of Catabolism and Anabolism: Convergence of Animal and Human Studies

5 Therapeutic Approaches to Overcome the Anorexia of Aging and Its Deleterious Effects on Body Functions

6 Conclusions and Perspectives





First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms.

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

This volume focuses on anorexia.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Researchers, faculty, and graduate students interested in cutting-edge review concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested


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About the Serial Editors

Gerald Litwack Serial Editor

Following a liberal arts education with a major in chemistry and biology at Hobart College, Gerald (Gerry) Litwack earned M.S. and PhD degrees in biochemistry from the University of Wisconsin, Madison where he served as a Lecturer in Enzymology before starting a postdoctoral fellowship from the National Foundation for Infantile Paralysis at the Biochemical Institute of the Sorbonne in Paris. His first academic position was assistant professor of biochemistry at Rutgers University where he started his work on hormone action for six years. During this period, he did a sabbatical at the University of California, Berkeley, where he concentrated on rapid enzyme kinetics. In 1960 he accepted an offer of an associate professorship at the University of Pennsylvania Graduate School of Medicine. In 1964, he was invited to be full professor of biochemistry at The Fels Institute for Cancer Research and Molecular Biology at Temple Medical School, simultaneously with a Career Development Award from the NIH, where he later was named Deputy Director of the Institute and the Laura H. Carnell Professor in biochemistry. Subsequently, he was given the Faculty Research Award. He co-discovered ligandin, later found to be in the family of glutathione S-transferases, enzymes that protect the body from carcinogens. In 1991, he moved to the Jefferson Medical College at Thomas Jefferson University as Professor of Biochemistry, Chair of the Department of Pharmacology and Deputy Director of the Kimmel Cancer Research Institute. Later, he became chair of the combined Department of Biochemistry and Molecular Pharmacology and concurrently held the position of Vice Dean for Research. In 2003, he moved to Los Angeles and from 2004-2006 was a Visiting Scholar at the University of California, Los Angeles, in the Department of Biological Chemistry of the Geffen School of Medicine and, in this period, wrote “Human Biochemistry and Disease” a volume of 1254 pages. In 2007, he moved to Scranton, Pennsylvania, as Founding Chair of Basic Sciences and Acting Associate Dean for Research to start a new medical school, The Commonwealth Medical College. Having completing his mission in 2010, he moved to The Institute for Regenerative Medicine, Texas A & M Health Science Center, as Professor of Biochemistry and Associate Director. Currently, he is retired and lives in North Hollywood, California, where he continues as an author and as Series Editor of Vitamins and Hormones. He is involved in writing another textbook and has written a first novel, “One-Eighty”.

Affiliations and Expertise

Toluca Lake, North Hollywood, California, USA