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Anorexia - 1st Edition - ISBN: 9780124104730, 9780124104808

Anorexia, Volume 92

1st Edition

Serial Editor: Gerald Litwack
Hardcover ISBN: 9780124104730
eBook ISBN: 9780124104808
Imprint: Academic Press
Published Date: 16th April 2013
Page Count: 392
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Table of Contents

Former Editors



Chapter One. Novel Neuropeptides in the Control of Food Intake

1 Introduction

2 Neuronostatin

3 Nesfatin-1

4 Conclusions


Chapter Two. Anorexia and Hypothalamic Degeneration

1 Introduction

2 The anx/anx Mouse

3 General Aspects of Mechanisms Underlying Weight Disturbances

4 Neurodegeneration and Mitochondrial Dysfunction Related to Eating Disorders in Humans

5 Conclusions and Future Directions



Chapter Three. The Role of Ghrelin in Anorexia–Cachexia Syndromes

1 Introduction

2 Discovery of Ghrelin

3 Ghrelin, GHS-R1a, and GOAT

4 Mechanisms of Action of Ghrelin

5 Ghrelin and Sarcopenia of Aging

6 Ghrelin and Cancer Cachexia

7 Ghrelin and COPD-Induced Cachexia

8 Ghrelin and Anorexia Nervosa

9 Ghrelin and CHF-Induced Cachexia

10 Ghrelin and ESRD

11 AIDS-Associated Cachexia

12 RA-Associated Cachexia

13 Conclusions



Chapter Four. Ghrelin Gene Variants and Eating Disorders

1 Introduction

2 Ghrelin Signaling System

3 Physiological Functions of Ghrelin

4 Ghrelin and Eating Disorders

5 Ghrelin Gene Variants and Eating Disorders

6 Association of Ghrelin Polymorphisms with Anthropometry and Eating Pathology in Young Women

7 Association of Ghrelin Polymorphisms with Changes in Eating Disorder Phenotypes

8 Conclusions


Chapter Five. Steroid Metabolism and Excretion in Anorexia Nervosa

1 Introduction

2 Steroid Metabolism in Health

3 Steroid Metabolism in AN

4 Steroid Excretion in AN

5 Effects of Refeeding

6 Conclusions



Chapter Six. Anorexia Nervosa and Estrogen Receptors

1 Introduction

2 Anorexia Nervosa

3 Estrogens and Estrogen Receptors and Pathways

4 Estrogen and Anorexia

5 Human Genetics of Estrogen Pathway in Anorexia Nervosa

6 Conclusions


Chapter Seven. Cannabinoid Receptors and Cholecystokinin in Feeding Inhibition

1 Introduction: Peripheral Regulation of Food Intake: A Place for Endocannabinoids and Cholecystokinin

2 The Endocannabinoids and Feeding Regulation

3 CCK and Feeding Regulation

4 Interactions Between CCK and Endocannabinoid Receptors in the Regulation of Feeding

5 Conclusions and Clinical Relevance



Chapter Eight. Treatment of Cachexia

1 Introduction

2 Molecular Mediators of Cachexia

3 Peripheral and Central Appetite Regulation

4 Cancer Cachexia

5 Cardiac Cachexia

6 Renal Cachexia

7 Other Cachexia

8 Summary of Treatment Effects

9 Future Directions


Chapter Nine. The Influence of Estrogen Therapies on Bone Mineral Density in Premenopausal Women with Anorexia Nervosa and Amenorrhea

1 Introduction

2 Estrogen Therapy and Bone Mass

3 Potential Clinical Drawbacks of Estrogen Therapy for Patients with AN

4 Influence of Oral Contraceptives on Bone Mineral Density

5 Influence of Hormone Replacement Therapy on Bone Mineral Density

6 The Role of Insulin-Like Growth Factor 1 and Estrogen on Bone Mineral Density

7 Implications


Chapter Ten. Clinical and Hormonal Variables Related to Bone Mass Loss in Anorexia Nervosa Patients

1 Introduction

2 Materials and Methods

3 Results

4 Discussion




Chapter Eleven. Mechanism-Based Therapeutic Approaches to Cachexia

1 Introduction

2 Body and Tissue Wasting

3 Anorexia

4 Inflammation

5 Tissue Wasting in Cachexia: Hypoanabolism or Hypercatabolism?

6 From Mechanistic Alterations to Therapeutic Strategies

7 Nutritional Interventions

8 Anti-Inflammatory Strategies

9 Inhibition of Cytokine Production

10 Interference with Cytokine-Receptor Interaction

11 Strategies to Correct Metabolic Alterations

12 Conclusions


Chapter Twelve. Cisplatin-Induced Anorexia and Ghrelin

1 Introduction

2 Cisplatin-Induced Overproduction of 5-HT

3 Cisplatin, 5-HT-Induced Ghrelin Regulation

4 Treatment of Ghrelin- and Ghrelin Enhancer-Based, Cisplatin-Caused Dyspepsia

5 Conclusion


Chapter Thirteen. Anorexia of Aging

1 Introduction

2 Animal Studies

3 Human Studies

4 Anorexia of Aging May Result from the Imbalance of Catabolism and Anabolism: Convergence of Animal and Human Studies

5 Therapeutic Approaches to Overcome the Anorexia of Aging and Its Deleterious Effects on Body Functions

6 Conclusions and Perspectives





First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms.

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

This volume focuses on anorexia.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Researchers, faculty, and graduate students interested in cutting-edge review concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested


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© Academic Press 2013
16th April 2013
Academic Press
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Ratings and Reviews

About the Serial Editor

Gerald Litwack

Gerald Litwack

Dr. Gerald Litwack obtained M.S. and PhD degrees from the University of Wisconsin Department of Biochemistry and remained there for a brief time as a Lecturer on Enzymes. Then he entered the Biochemical Institute of the Sorbonne as a Fellow of the National Foundation for Infantile Paralysis. He next moved to Rutgers University as an Assistant Professor of Biochemistry and later as Associate Professor of biochemistry at the University of Pennsylvania Graduate School of Medicine. After four years he moved to the Temple University School of Medicine as Professor of Biochemistry and Deputy Director of the Fels Institute for Cancer Research and Molecular Biology, soon after, becoming the Laura H. Carnell Professor. Subsequently he was appointed chair of Biochemistry and Molecular Pharmacology at the Jefferson Medical College as well as Vice Dean for Research and Deputy Director of the Jefferson Cancer Institute and Director of the Institute for Apoptosis. Following the move of his family, he became a Visiting Scholar at the Department of Biological Chemistry of the Geffen School of Medicine at UCLA and then became the Founding Chair of the Department of Basic Sciences at the Geisinger Commonwealth School of Medicine, becoming Professor of Molecular and Cellular Medicine and Associate Director of the Institute for Regenerative Medicine at the Texas A&M Health Science Center as his final position. During his career he was a visiting scientist at the University of California, San Francisco and Berkeley, Courtauld Institute of Biochemistry, London and the Wistar Institute. He was appointed Emeritus Professor and/or Chair at Rutgers University, Thomas Jefferson University and the Geisinger Commonwealth School of Medicine. He has published more than 300 scientific papers, authored three textbooks and edited more than sixty-five books. Currently he lives with his family and continues his authorship and editorial work in Los Angeles.

Affiliations and Expertise

Toluca Lake, North Hollywood, California, USA