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1. Challenges in developing quadruplex therapeutics
2. Fundamentals of quadruplex biology
3. Quadruplex folding and diversity
Anh Tuân Phan
4. Telomeric quadruplexes as therapeutic targets
5. Viral G-quadruplexes: new frontiers in virus pathogenesis and antiviral therapy
Sara N. Richter
6. Quadruplex targeting in infective and parasitic diseases
7. Quadruplex detection in cells
8. An overview of quadruplex ligands: their common features and chemotype diversity
9. Quadruplex simulations and drug design
10. Lead discovery of quadruplex-binding small molecules
11. Click and combinatorial approaches to quadruplex ligand discovery
12. Targeting k-RAS quadruplexes
13. Targeting MYC by quadruplex approaches
14. Targeting KIT quadruplexes
15. Quadruplex targets in neurodegenerative diseases
16. Metallo-containing quadruplex ligands
The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human clinical trials.
- Provides the authority and expertise of leading contributors from an international board of authors
- Presents the latest release in the Annual Reports in Medicinal Chemistry series
Undergraduates, graduates, academics and researchers in the field of medicinal chemistry
- No. of pages:
- © Academic Press 2020
- 1st September 2020
- Academic Press
- Hardcover ISBN:
Stephen Neidle, DSc, PhD, ARCS, FRSC, Director of Cancer Research UK Biomolecular Structure Group, Director of the Centre for Cancer Medicines, Professor of Chemical Biology, The School of Pharmacy, University College London, UK
The School of Pharmacy, University College London, UK
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