Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

Key Features

Timely and critical reviews of important topics in medicinal chemistry


medicinal, pharmaceutical, and organic chemists

Table of Contents

Personal Essay

  1. Reflections on Medicinal Chemistry at Merck, West Point
  2. Paul S. Anderson

  3. My Path in Seeking New Medicines
  4. Peter R. Bernstein

  5. Tales of Drug Discovery
  6. M. Ross Johnson

    I. Central Nervous System Diseases

    Section Editor: Albert J. Robichaud; Sage Therapeutics, Inc. Cambridge, Massachusetts

  7. Recent Developments in Targeting Neuroinflammation in Disease
  8. Allen T. Hopper, Brian M. Campbell, Henry Kao, Sean A. Pintchovski and Roland G. W. Staal

  9. Secretase Inhibitors and Modulators as a Disease Modifying Approach Against Alzheimer’s Disease
  10. Harrie J. M. Gijsen and François P. Bischoff

  11. mGluR2 Activators and mGluR5 Blockers Advancing in the Clinic for Major CNS Disorders
  12. Sylvain Célanire, Guillaume Duvey, Sonia Poli and Jean-Philippe Rocher

  13. NMDA Antagonists of GluN2B Subtype and Modulators of GluN2A, GluN2C and GluN2D Subtypes – Recent Results and Developments
  14. Kamalesh B. Ruppa, Dalton King and Richard Olson

  15. Recent Advances in the Development of PET and SPECT Tracers for Brain Imaging
  16. Lei Zhang and Anabella Villalobos

    II. Cardiovascular and Metabolic Diseases

    Section Editor: Andy Stamford, Merck Research Laboratories, Kenilworth, New Jersey

  17. Case History: EliquisTM (Apixaban), a Potent and Selective Inhibitor of Coagulation Factor Xa for the Prevention and Treatment of Thrombotic Diseases
  18. Donald J. P. Pinto, Pancras C. Wong, Robert M. Knabb and Ruth R. R. Wexler

  19. AMPK Activation in Health and Disease
  20. Iyassu K. Sebhat and Robert W. Myers

  21. Ty


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© 2012
Academic Press
Print ISBN:
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This series is one of the very few annual publications which justify the title of an absolute must for the pharmacologist, chemist, or physician who is interested in the chemistry of drug development." - ENZYMOLOGIA