Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.


medicinal, pharmaceutical, and organic chemists

Table of Contents

1 mGlu4 Modulators Kevin Liu
2 Recent Advances towards Pain Therapeutics Philippe Nantermet
3 Circadian Rythym Paul Galatsis
4 Recent Progress in the Discovery of Kv7.x Modulators’ Ismet Dorange
5 Bile Acid Receptor Modulators for Treatment of Metabolic Diseases Yanping Xu
6 Mineralocorticoid Receptor Antagonists Katerina Leftheris
7 SGLT2 Inhibitors for the Treatment of Diabetes Jiwen Liu, TaeWeon Lee
8 CRTh2 Antagonists Laurence E. Burgess
9 Developments and Advances in Gastrointestinal Prokinetic Agents James W. Dale
10 Targeting Th17 and Treg Signaling Pathways in Autoimmunity Shomir Ghosh
11 Advances in the Discovery of C5a Receptor Antagonists Jay P. Powers
12 Inhibition of Translation Initiation as a Novel Paradigm for Cancer
13 The Development of Inhibitor of Apoptosis Protein Antagonists for the Treatment of Resistant Cancers. Stephen Condon
14 Case History on the Discovery of Halaven® Melvin Lu
15 Emerging New Therapeutics against Key Gram-negative Pathogens Daniel Obrecht
16 Hepatitis C Virus Inhibitors – Beyond NS3 Protease and NS5B
17 The Emergence of Small Molecule Modulators of the Capsid Assembly Pathway as Potential Antiviral Therapeutics Clarence R. Hurt 
18 Mechanism of Action (MoA) in Drug Discovery David Swinney
19 Aryl Hydrocarbon Receptor (AhR) Activation: An Emerging
20 Prolyl Isomerases Pat Flaherty
21 Potential Therapeutic Applications of miRNA Graham Brock
22 Induced Pluripotent Stem Cells (iPSC) as Drug Discovery Tools and Human Disease Models Charles R. Johnson
23 Progress in Drug Repositioning: Old Drugs, New Opportunities Michael A. Walters
24 Deuterium in Drug Discovery and Development Scott L. Harbeson
25 Phospholipidosis Peter Bernstein
26 To Market, To Market 2010 Joanne Bronson


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© 2011
Academic Press
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This series is one of the very few annual publications which justify the title of an absolute must for the pharmacologist, chemist, or physician who is interested in the chemistry of drug development." - ENZYMOLOGIA