Annual Reports in Medicinal Chemistry, Volume 45

1st Edition

Series Editors: John Macor
Paperback ISBN: 9780123809025
eBook ISBN: 9780123809032
Imprint: Academic Press
Published Date: 25th October 2010
Page Count: 648
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Table of Contents

Section I: Central Nervous System Diseases – ROBICHAUD

  1. Voltage-Gated Calcium Channel Antagonists for the Central Nervous System
  2. James C. Barrow and Joseph L. Duffy

  3. Recent Developments in Glycine Transporter-1 Inhibitors
  4. Christopher L. Cioffi, Shuang Liu and Mark A.Wolf

  5. Modulators of Transient Receptor Potential Ion Channels
  6. Rajagopal Bakthavatchalam and S. David Kimball

  7. Defining Neuropharmacokinetic Parameters in CNS Drug Discovery to Determine Cross-species Pharmacologic Exposure-Response Relationships
  8. Christopher L. Shaffer

    Section II: Cardiovascular and Metabolic Diseases - STAMFORD

  9. High Affinity Niacin Receptor GPR109A Agonists
  10. Hong C. Shen and Steven L. Colletti

  11. Recent Advances in Acetyl CoA Carboxylase (ACC) Inhibitors
  12. Matthew P. Bourbeau, John G. Allen, and Wei Gu

  13. Enzymatic Targets in the Triglyceride Synthesis Pathway
  14. Dmitry O. Koltun and Jeff Zablocki

  15. Inhibitors of HIF Prolyl Hydroxylases
  16. Michael H. Rabinowitz, Terrance D. Barrett, Mark D. Rosen, Hariharan Venkatesan

    Section III: Inflammation / Pulmonary / GI - BARRISH/Weinstein

  17. Opioid Receptor Antagonists for Gastrointestinal Dysfunction
  18. R. William Hipkin and Roland E. Dolle

  19. CFTR Modulators for the Treatment of Cystic Fibrosis
  20. Sabine Hadida, Frederick Van Goor and Peter D. J. Grootenhuis

  21. Targeting B-cells in inflammatory disease
  22. Kevin S. Currie

  23. Modulators of Toll-Like Receptor (TLR) Signaling
  24. Mark Spyvee, Lynn Hawkins, and Sally Ishizaka

    Section IV: Oncology - McAlpine

  25. Janus Kinase 2 (JAK2) inhibitors for the treatment of myeloproliferative neoplasm (MPN)
  26. A


Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

Key Features

  • Covers findings related to cardiovascular, inflammation, and pulmonary diseases

    Examines issues in oncology, from mTor inhibitors to drug targets

    Incorporates up-to-date information on drug design and discovery, including delivery to market


medicinal, pharmaceutical, and organic chemists


No. of pages:
© Academic Press 2010
Academic Press
eBook ISBN:
Paperback ISBN:

About the Series Editors

John Macor Series Editor

Affiliations and Expertise

Neuroscience Discovery Chemistry, Bristol-Myers Squibb, USA