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I. CENTRAL NERVOUS SYSTEM DISEASES
Neuronal Nicotinic Acetylcholine Receptor Modulators: Recent Advances and Therapeutic Potential (S.R. Breining et al.).
Recent Advances in Selective Serotonergic Agents (W.E. Childers, Jr., A.J. Robichaud).
BACE Inhibitors for the Treatment of Alzheimer’s Disease (E.W. Baxter, A.B. Reitz).
Positron Emission Tomography Agents for Central Nervous System Drug Development Applications (N. Scott Mason, C. Mathis).
II. CARDIOVASCULAR AND METABOLIC DISEASES
Emerging Topics in Atherosclerosis HDL Raising Therapies (P.J. Sinclair).
Small Molecule Anticoagulant/Antithrombotic Agents (R.M. Scarborough et al.).
CB1 Cannabinoid Receptor Antagonists (F. Barth).
Melanin-Concentrating Hormone as a Therapeutic Target (M.D. McBriar, T.J. Kowalski).
Glycogen Synthase Kinase-3 (GSK-3): A Kinase with Exceptional Therapeutic Potential (J.W. Benbow et al.).
Inhibitors of Dipeptidyl Peptidase 4 as Therapeutic Agents (S.L. Gwaltney II, J.A. Stafford).
Recent Advances in Therapeutic Approaches to Type 2 Diabetes (R. Sarabu, J. Tilley).
III. INFLAMMATORY, PULMONARY, AND GASTROINTESTINAL DISEASES
The TRPV1 Vanilloid Receptor: A Target for Therapeutic Intervention (J. Guy Breitenbucher et al.).
Leukotriene Biosynthesis Inhibitors (R.W. Friesena, D. Riendeaub).
CXCR3 Antagonists (J.C. Medina et al.).
PDE7 inhibitors: chemistry and potential therapeutic utilities (F. Vergne et al.).
IV. CANCER AND INFECTIOUS DISEASES
Inhibitors of Anti-apoptotic Proteins for Cancer Therapy (S.W. Elmore et al.).
AKT Kinase and Hsp90 Inhibitors As Novel Anti-cancer Therapeutics (T. Machajewski et al.).
Novel Strategies in HIV Prevention – Development of Topical Microbicides (B.E. Beer, J.E. Cummins, Jr.).
New Developments in HIV Therapeutics (T.A. Lylea, M.D. Millerb).
Antibacterials for the Treatment of Gram Positive Infections (J.B. McAlpinea, Morimasa Yagisawab).
Progress on New Therapeutics for Fungal Nail Infections (S.J. Baker et al.).
V. TOPICS IN BIOLOGY
22. Chemical Tools for Indications Discovery (A. Hopkins).
- Structural Genomics and Drug Discovery (A. Edwards et al.).
VI. TOPICS IN DRUG DESIGN AND DISCOVERY
Structural Genomics and Drug Discovery (A. Edwards et al.).
G-Protein Coupled Receptor Inverse Agonists: Identification, Pharmacological Relevance and Functional Assays (B.L. Chenard et al.).
The Utility of Metabonomics for Drug Safety Assessment (M. Delnomdedieu, R.P. Schneider).
Computational Prediction of Blood-brain Barrier Permeation (D.E. Clark).
Pharmacogenetics and Drug Development (H. Reiser).
VII. TRENDS AND PERSPECTIVES
29. Trends in Pharmaceutical Innovation (E.F. Schmid, D.A. Smith).
- To Market, To Market – 2004 (S. Hegde, M. Schmidt).
Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies. Sections I-IV are disease orientated and generally report on specific medicinal agents. Sections V and VI continue to emphasize important topics in medicinal chemistry, biology, and drug design. Section VII looks at Trends and Perspectives in the pharmaceuticals market.
- Critical reviews of the previous year's literature in many topics of interest to medicinal chemists
- Highlights major developments in medicinal chemistry
- Includes a comprehensive set of cumulative indices to easily locate topics in all published volumes
medicinal, pharmaceutical and organic chemists
- No. of pages:
- © Academic Press 2005
- 19th December 2005
- Academic Press
- Paperback ISBN:
- eBook ISBN:
Pfizer Global R&D, Sandwich Laboratories, United Kingdom
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