Description

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

Key Features

  • Annual Reports in Medicinal Chemistry provides timely and critical reviews and this volume covers important topics such as drug Discovery, Idiopathic Pulmonary Fibrosis and Neuraminidase Inhibitors

Readership

medicinal, pharmaceutical, and organic chemists

Table of Contents

Contributors

Preface

Personal Essays

Chapter One. Challenges in Drug Discovery at Schering–Plough Research Institute: A Personal Reflection

Abstract

Acknowledgments

References

Chapter Two. My Perspective on Time, Managers—and Scientific Fun

1 Controlling Your Scientific Life: Time Management

2 Foster Innovation with Scientific Fun

3 A Good Manager is a Scientist’s Best Friend

References

Chapter Three. A Career in Medicinal Chemistry—A Journey in Drug Discovery

Abstract

1 Early Days in Nucleoside, Nucleotide, and Nucleic Acid Chemistry

2 Antivirals

3 Elastase Inhibitors

4 Substance P Antagonists and the Discovery of Aprepitant and Fosaprepitant

5 Hypoglycemic Agents and the Discovery of Sitagliptin

6 Conclusions

References

Section 1: Central Nervous System Diseases

Chapter Four. Selective Inhibitors of PDE2, PDE9, and PDE10: Modulators of Activity of the Central Nervous System

Abstract

1 Introduction

2 Phosphodiesterase (PDE) Structures

3 PDE2 Inhibitors and Dual PDE2 + PDE10 Inhibitors

4 PDE9 Inhibitors

5 PDE10 Inhibitors

6 Conclusions

References

Chapter Five. Beyond Secretases: Kinase Inhibitors for the Treatment of Alzheimer’s Disease

Abstract

1 Introduction

2 Inhibitors of Dual-Specificity Kinases

3 Inhibitors of Serine–Threonine Kinases

4 Conclusions

References

Chapter Six. Orexin Receptor Antagonists in Development for Insomnia and CNS Disorders

Abstract

1 Introduction

2 Clinical Programs

3 Preclinical Programs

4 Potential Indications Beyond Sleep

5 Concluding Remarks

References

Section 2: Cardiovascular and Metabolic Diseases

Chapter Seven. Discovery an

Details

No. of pages:
672
Language:
English
Copyright:
© 2013
Published:
Imprint:
Academic Press
Print ISBN:
9780124171503
Electronic ISBN:
9780124171510

Reviews

"This series is one of the very few annual publications which justify the title of an absolute must for the pharmacologist, chemist, or physician who is interested in the chemistry of drug development." --Enzymeologia