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Anionic Annulations in Organic Synthesis: A Versatile and Prolific Class of Ring-Forming Reactions is a comprehensive review of the main annulations for the construction of cyclic… Read more
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Anionic Annulations in Organic Synthesis: A Versatile and Prolific Class of Ring-Forming Reactions is a comprehensive review of the main annulations for the construction of cyclic structures and their use in the total synthesis of functional molecules. The book explores in detail the Hauser, Robinson, Sammes, and Myers annulations, all of which are beneficial to constructing substrates with complex molecular structures suitable for pharmaceutical purposes.
This volume begins with an in-depth introduction on the history and perspectives of annulations. It then covers different categories of annulation in each chapter, examining their application to drug synthesis for a range of different medicinal compounds.
Anionic Annulations in Organic Synthesis
delivers a thorough analysis of the topic and provides the tools necessary to master anionic organic chemistry. It is a valuable resource for chemists, researchers, and students seeking a complete and detailed understanding of anionic annulations.Researchers and academicians in the area of synthetic organic chemistry. Secondary: graduate students in these same areas
1. Introduction2. Hauser [4 + 2] Annulation: Definition, History, Mechanism, and Types of Phthalide Donors and Toluate Donors3. Lateral Lithiations4. [4+2] Annulation of 3-Nuclofugal Phthalides (Hauser Annulation)5. [4+2] Annulation With Nonactivated Phthalides (Sammes Annulation)6. [4+2] Annulation of Homophthalic Anhydrides7. [4+2] Annulation of Activated o-Toluate/o-Tolualdehyde Donors (Hauser-Leusen Annulation)8. [4+2] Annulation With Nonactivated o-Toluate Donors (Staunton-Weinreb-Myers Annulation)9. Comparative Annulation Chemistry of Phthalides, Homophthalic Anhydrides and o-Toluates10. Applications of [4+2] Anionic Annulations in the Total Synthesis11. Miscellaneous Anionic Annulations 12. Concluding remarksAppendix: Problems and exercises
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