Animal Virus Genetics

Animal Virus Genetics

1st Edition - January 1, 1980

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  • Editors: Bernard N. Fields, Rudolf Jaenisch
  • eBook ISBN: 9781483272610

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Animal Virus Genetics is a collection of scientific presentations of the ICN-UCLA Symposia on Molecular and Cellular Biology, held at the University of California, Los Angeles in 1980. The papers in the compendium focus on the basic genetic model systems; the uses of genetic approaches to study basic problems in molecular biology; and on the increasing application of genetic systems to the study of more complex viral-host interactions such as viral virulence and persistence. Microbiologists, cellular biologists, and virologists will find the book insightful.

Table of Contents

  • Contributors


    I. Procaryotic Models

    1 IS—Elements and Transposons

    2 A Modular Theory of Virus Evolution

    II. Genome Structure and Organization

    3 Molecular Cloning of the Human Cytomegalovirus Genome (Strain AD 169)

    4 Structural Organization of the DNA Molecules from Human Cytomegalovirus

    5 The Nucleotide Sequence of the Hepatitus B Viral Genome and the Identification of the Major Viral Genes

    6 Correlating Genetic Mutations of a Baculovirus with the Physical Map of the DNA Genome

    7 Analysis of VSV Glycoprotein Structure and Genome Structure Using Cloned DNA

    8 Ribosome Binding to Polio Virus RNA

    9 Sequence Analysis of the Poliovirus Genome and Mapping of the Genome-Linked Protein

    10 Reovirus Genome RNA: Common 3'-Terminal Nucleotide Sequences and Assignment of mRNA Ribosome Binding Sites to Virion Genome Segments

    11 Terminal Sequence Homologies in Reovirus Genes

    III. Cellular Genes

    12 Attempts at the Molecular Cloning of a Transforming Allele from Chemically Transformed Mouse Cells

    13 Mechanisms of DNA-Mediated Transformation in Animal Cells

    14 Chromosomal Mapping of Ecotropic and Xenotropic Leukemia Virus-Inducing Loci in the Mouse

    15 Correlation between the Development of Murine Mammary Cancer and the Segregation of Endogenous Genes

    16 A Study of the Endogenous Moloney-Related Sequences of Mice

    17 Structural and Genetic Relationships between an Endogenous Retrovirus (M432) of Mus cervicolor and Intracisternal A-Particles of Mus musculus

    18 Genetic Control of MuLV Expression and Spontaneous Lymphoma in Crosses of High- and Low-Lymphoma Strains

    19 The Anomalous Antibody Response of Hybrid Mice to Immunization with an Abelson Virus Lymphoma

    20 AKvr-1, A Dominant Murine Leukemia Virus Restriction Gene, Segregates in Leukemia-Prone Wild Mice

    21 Genetic Control of Resistance of Mouse Hepatitis Virus, Strain JHM, Induced Encephalomyelitis

    IV. Integration

    22 Learning about the Replication of Retroviruses from a Single Cloned Provirus of Mouse Mammary Tumor Virus

    23 Observations on the DNA Sequence of the Extended Terminal Redundancy and Adjacent Host Sequences for Integrated Mouse Mammary Tumor Virus

    24 Derivation of Three Mouse Strains Carrying Moloney Leukemia Virus in Their Germ Line at Different Genetic Loci

    25 A Human Hepatoma Cell Line Contains Hepatitis B DNA and RNA Sequences

    V. Regulation and Expression

    26 Polyoma Virus HR-T Gene Products

    27 Complementation Studies with Transformation Defective Mutants of Polyoma Virus

    28 Analysis of Adenovirus-Induced Cellular DNA Synthesis in a ts Mutant of the Cell Cycle

    29 Regulation of Adenovirus Early Gene Expression

    30 Methylation and Expression of Adenoviral DNA in Infected and Transformed Cells

    31 Synthesis of Adenovirus 2 RNA in vitro: Properties of the Major Late Transcript and Its Promoter

    32 A Gene Function of Herpes Simplex Virus Required for Expression of All Early Viral Genes

    33 A Variant VSV Generates Defective Interfering Particles with Replicase-like Activity in vitro

    34 Separation of Full Length Transcripts and Genome RNA Plus and Minus Strands from Cytoplasmic Polyhedrosis Virus of Bombyx mori

    35 Differential Methylation of Endogenous and Acquired Mouse Mammary Tumor Virus-Specific DNA

    36 SFFV Specific Gene Expression in Infected and Erythroleukemia Cells

    37 Molecular Genetics and Cell Culture Assays for Helper-Independent and Replication-Defective Components of the Friend Virus Complex

    38 Viral Envelope Genes and c Regions in Non-acute Avian Leukosis Virus-Associated Disease

    VI. Transformation

    39 Two Regions of the Moloney Leukemia Virus Genome Are Required for Efficient Transformation by src/sarc

    40 Molecular Cloning of Moloney Mouse Sarcoma Virus Specific Sequences from Uninfected Mouse Cells

    41 Characterization of Molecularly Cloned Spleen Focus-Forming Virus DNA

    42 The Nature and Origin of the Transforming Gene of Avian Sarcoma Viruses

    43 Phosphorylation of Tyrosine: A Mechanism of Transformation Shared by a Number of Otherwise Unrelated RNA Tumor Viruses

    44 PRCII, A New Type of Avian Sarcoma Virus

    45 Fujinami Sarcoma Virus and Sarcomagenic, Avian Acute Leukemia Viruses Have Similar Genetic Structures

    46 A Model for Focma Expression in Cells Transformed by Feline Leukemia and Sarcoma Viruses

    47 Transformation-Defective Mutants of AEV and MC29 Avian Leukemia Viruses Synthesize Smaller gag-Related Proteins

    48 Isolation and Characterization of Phenotypic Revertants from Moloney Murine Sarcoma Virus-Transformed Cells

    VII. Viral Gene Products and Assembly

    49 Genetics of Acycloguanosine Resistance and the Thymidine Kinase Gene in HSV-1

    50 Study of Genetic Variability of Viruses through the Use of Monoclonal Antibodies

    51 Vesicular Stomatitis Virus Morphogenesis Is Accompanied by Covalent Protein Modifications

    52 Uncoupling of the Hemagglutinating and Neuraminidase Activities of Newcastle Disease Virus (NDV)

    53 Suppression of Temperature-Sensitive Phenotype in Reovirus: An Alternate Pathway from ts to ts+ Phenotype

    54 Translation Products of the 124 Strain of Moloney Murine Sarcoma Virus (Mo-MuSV): Characterization of a 23,000 Dalton Candidate 'src' Gene Product

    55 Characterization and Genetic Analysis of Retrovirus Maturation: A Role for Pr180gag-pal

    VIII. Viral Virulence and Persistence

    56 The Molecular Basis of Reovirus Virulence

    57 A Genetic Approach to Cytopathogenicity, Virus Spread, and Virulence of Newcastle Disease Virus (NDV)

    58 In Vitro Selection of An Attenuated Variant of Sindbis Virus

    59 Viral Mutation in Persistent Infection

    60 Antigenic Variation of Visna Virus

    61 Possible Mechanism of Rotavirus Persistence

    62 Neurovirulence and Persistency of Mouse Hepatitis Viruses in Rats

    63 Persistent Infections of Bunyaviruses in Aedes albopictus

    64 Experimental Relapsing Myelitis in Hamsters Associated with a Variant of Measles Virus

    65 Antibody-Induced Modulation of Viral Antigens from Infected Cells: Biological and Molecular Studies of Measles Virus Infection and Implications for Understanding Virus Persistence and Receptor Diseases

    IX. Workshops

    66 Herpes and Pox Virus

    67 Adenovirus/SV40/Polyoma I

    68 Adenoviruses/SV40/Polyoma II

    69 Picornaviruses/Togaviruses/Hepatitis/Coronaviruses

    70 Rhabdoviruses and Paramyxoviruses

    71 Segmented RNA Viruses

    72 Cell Genes and Viral Transformation

    73 Immunogenetics of Animal Viruses


Product details

  • No. of pages: 856
  • Language: English
  • Copyright: © Academic Press 1980
  • Published: January 1, 1980
  • Imprint: Academic Press
  • eBook ISBN: 9781483272610

About the Editors

Bernard N. Fields

Rudolf Jaenisch

Rudolf Jaenisch produced the first transgenic animals in the 1970. In the 80’s and 90’s his lab made many contributions to the understanding of cancer, neurological diseases, and the role of DNA methylation in mammalian development using transgenic mice. The lab was one of three labs worldwide that reported in 2007 cells taken from mouse tails could be reprogrammed into iPSCs by over-expressing four master gene regulators. Later that year, the lab followed up by further manipulating iPSCs to treat sickle-cell anemia in mice, the first proof in principle of therapeutic use of such cells. In 2008, the lab reported that neurons derived from iPSCs successfully integrated into fetal mouse brains and reduced symptoms in a Parkinson’s disease rat model. The Jaenisch Lab focuses on understanding the genetic and epigenetic basis of familial and sporadic diseases.

Affiliations and Expertise

Whitehead Institute Cambridge, MA, USA

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