Animal Virus Genetics - 1st Edition - ISBN: 9780122558504, 9781483272610

Animal Virus Genetics

1st Edition

Editors: Bernard N. Fields Rudolf Jaenisch
eBook ISBN: 9781483272610
Imprint: Academic Press
Published Date: 1st January 1980
Page Count: 856
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Animal Virus Genetics is a collection of scientific presentations of the ICN-UCLA Symposia on Molecular and Cellular Biology, held at the University of California, Los Angeles in 1980.

The papers in the compendium focus on the basic genetic model systems; the uses of genetic approaches to study basic problems in molecular biology; and on the increasing application of genetic systems to the study of more complex viral-host interactions such as viral virulence and persistence. Microbiologists, cellular biologists, and virologists will find the book insightful.

Table of Contents



I. Procaryotic Models

1 IS—Elements and Transposons

2 A Modular Theory of Virus Evolution

II. Genome Structure and Organization

3 Molecular Cloning of the Human Cytomegalovirus Genome (Strain AD 169)

4 Structural Organization of the DNA Molecules from Human Cytomegalovirus

5 The Nucleotide Sequence of the Hepatitus B Viral Genome and the Identification of the Major Viral Genes

6 Correlating Genetic Mutations of a Baculovirus with the Physical Map of the DNA Genome

7 Analysis of VSV Glycoprotein Structure and Genome Structure Using Cloned DNA

8 Ribosome Binding to Polio Virus RNA

9 Sequence Analysis of the Poliovirus Genome and Mapping of the Genome-Linked Protein

10 Reovirus Genome RNA: Common 3'-Terminal Nucleotide Sequences and Assignment of mRNA Ribosome Binding Sites to Virion Genome Segments

11 Terminal Sequence Homologies in Reovirus Genes

III. Cellular Genes

12 Attempts at the Molecular Cloning of a Transforming Allele from Chemically Transformed Mouse Cells

13 Mechanisms of DNA-Mediated Transformation in Animal Cells

14 Chromosomal Mapping of Ecotropic and Xenotropic Leukemia Virus-Inducing Loci in the Mouse

15 Correlation between the Development of Murine Mammary Cancer and the Segregation of Endogenous Genes

16 A Study of the Endogenous Moloney-Related Sequences of Mice

17 Structural and Genetic Relationships between an Endogenous Retrovirus (M432) of Mus cervicolor and Intracisternal A-Particles of Mus musculus

18 Genetic Control of MuLV Expression and Spontaneous Lymphoma in Crosses of High- and Low-Lymphoma Strains

19 The Anomalous Antibody Response of Hybrid Mice to Immunization with an Abelson Virus Lymphoma

20 AKvr-1, A Dominant Murine Leukemia Virus Restriction Gene, Segregates in Leukemia-Prone Wild Mice

21 Genetic Control of Resistance of Mouse Hepatitis Virus, Strain JHM, Induced Encephalomyelitis

IV. Integration

22 Learning about the Replication of Retroviruses from a Single Cloned Provirus of Mouse Mammary Tumor Virus

23 Observations on the DNA Sequence of the Extended Terminal Redundancy and Adjacent Host Sequences for Integrated Mouse Mammary Tumor Virus

24 Derivation of Three Mouse Strains Carrying Moloney Leukemia Virus in Their Germ Line at Different Genetic Loci

25 A Human Hepatoma Cell Line Contains Hepatitis B DNA and RNA Sequences

V. Regulation and Expression

26 Polyoma Virus HR-T Gene Products

27 Complementation Studies with Transformation Defective Mutants of Polyoma Virus

28 Analysis of Adenovirus-Induced Cellular DNA Synthesis in a ts Mutant of the Cell Cycle

29 Regulation of Adenovirus Early Gene Expression

30 Methylation and Expression of Adenoviral DNA in Infected and Transformed Cells

31 Synthesis of Adenovirus 2 RNA in vitro: Properties of the Major Late Transcript and Its Promoter

32 A Gene Function of Herpes Simplex Virus Required for Expression of All Early Viral Genes

33 A Variant VSV Generates Defective Interfering Particles with Replicase-like Activity in vitro

34 Separation of Full Length Transcripts and Genome RNA Plus and Minus Strands from Cytoplasmic Polyhedrosis Virus of Bombyx mori

35 Differential Methylation of Endogenous and Acquired Mouse Mammary Tumor Virus-Specific DNA

36 SFFV Specific Gene Expression in Infected and Erythroleukemia Cells

37 Molecular Genetics and Cell Culture Assays for Helper-Independent and Replication-Defective Components of the Friend Virus Complex

38 Viral Envelope Genes and c Regions in Non-acute Avian Leukosis Virus-Associated Disease

VI. Transformation

39 Two Regions of the Moloney Leukemia Virus Genome Are Required for Efficient Transformation by src/sarc

40 Molecular Cloning of Moloney Mouse Sarcoma Virus Specific Sequences from Uninfected Mouse Cells

41 Characterization of Molecularly Cloned Spleen Focus-Forming Virus DNA

42 The Nature and Origin of the Transforming Gene of Avian Sarcoma Viruses

43 Phosphorylation of Tyrosine: A Mechanism of Transformation Shared by a Number of Otherwise Unrelated RNA Tumor Viruses

44 PRCII, A New Type of Avian Sarcoma Virus

45 Fujinami Sarcoma Virus and Sarcomagenic, Avian Acute Leukemia Viruses Have Similar Genetic Structures

46 A Model for Focma Expression in Cells Transformed by Feline Leukemia and Sarcoma Viruses

47 Transformation-Defective Mutants of AEV and MC29 Avian Leukemia Viruses Synthesize Smaller gag-Related Proteins

48 Isolation and Characterization of Phenotypic Revertants from Moloney Murine Sarcoma Virus-Transformed Cells

VII. Viral Gene Products and Assembly

49 Genetics of Acycloguanosine Resistance and the Thymidine Kinase Gene in HSV-1

50 Study of Genetic Variability of Viruses through the Use of Monoclonal Antibodies

51 Vesicular Stomatitis Virus Morphogenesis Is Accompanied by Covalent Protein Modifications

52 Uncoupling of the Hemagglutinating and Neuraminidase Activities of Newcastle Disease Virus (NDV)

53 Suppression of Temperature-Sensitive Phenotype in Reovirus: An Alternate Pathway from ts to ts+ Phenotype

54 Translation Products of the 124 Strain of Moloney Murine Sarcoma Virus (Mo-MuSV): Characterization of a 23,000 Dalton Candidate 'src' Gene Product

55 Characterization and Genetic Analysis of Retrovirus Maturation: A Role for Pr180gag-pal

VIII. Viral Virulence and Persistence

56 The Molecular Basis of Reovirus Virulence

57 A Genetic Approach to Cytopathogenicity, Virus Spread, and Virulence of Newcastle Disease Virus (NDV)

58 In Vitro Selection of An Attenuated Variant of Sindbis Virus

59 Viral Mutation in Persistent Infection

60 Antigenic Variation of Visna Virus

61 Possible Mechanism of Rotavirus Persistence

62 Neurovirulence and Persistency of Mouse Hepatitis Viruses in Rats

63 Persistent Infections of Bunyaviruses in Aedes albopictus

64 Experimental Relapsing Myelitis in Hamsters Associated with a Variant of Measles Virus

65 Antibody-Induced Modulation of Viral Antigens from Infected Cells: Biological and Molecular Studies of Measles Virus Infection and Implications for Understanding Virus Persistence and Receptor Diseases

IX. Workshops

66 Herpes and Pox Virus

67 Adenovirus/SV40/Polyoma I

68 Adenoviruses/SV40/Polyoma II

69 Picornaviruses/Togaviruses/Hepatitis/Coronaviruses

70 Rhabdoviruses and Paramyxoviruses

71 Segmented RNA Viruses

72 Cell Genes and Viral Transformation

73 Immunogenetics of Animal Viruses



No. of pages:
© Academic Press 1980
Academic Press
eBook ISBN:

About the Editor

Bernard N. Fields

Rudolf Jaenisch

Affiliations and Expertise

Whitehead Institute Cambridge, MA, USA

Ratings and Reviews