Animal Models of Molecular Pathology, Volume 105

1st Edition

Editors: P. Michael Conn
Hardcover ISBN: 9780123945969
eBook ISBN: 9780123948311
Imprint: Academic Press
Published Date: 12th December 2011
Page Count: 472
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Table of Contents



Animal Models of Atherosclerosis

I. Atherosclerosis Development: Basic Concepts

II. Animal Models of Atherosclerosis

III. Concluding Remarks


Genetic Animal Models of Cerebral Vasculopathies

I. Cerebral Amyloid Angiopathy

II. Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL)

III. Concluding Remarks


Experimental Models of Seizures and Epilepsies

I. Introduction

II. Classification of Epileptic Seizures

III. Classification of Epileptic Syndromes

IV. Models for Seizures and Epilepsies

V. Summary

Animal Models of Muscular Dystrophy

I. Dystrophin

II. The Sarcoglycans

III. Calcium and Dystrophic Pathology

IV. α-Actinin

V. Fukutin-Related Protein and Dystroglycan Processing

VI. Desmin

VII. Laminin α2

VIII. Collagen VI

IX. D4Z4 Repeats and FSHD

X. DMPK and Myotonic Dystrophy

XI. Conclusions


Acute Phase Proteins in Animals

I. The Acute Phase Response

II. Acute Phase Proteins

III. Clinical Value of APP

IV. APP in Animals

V. Concluding Remarks

Animal Models of Hemophilia

I. The Hemophilia A Mice

II. The Hemophilia B Mouse Model

III. The Hemophilia A and B Dogs

Animal Models of Lung Cancer

I. Lung Adenomas and Adenocarcinomas

II. Lung Squamous Cell Carcinoma

III. Lung Small Cell Carcinoma

IV. Chemopreventive Applications in Preclinical Lung Cancer Models

V. Conclusion

Cardiovascular Magnetic Resonance Imaging in Small Animals

I. Introduction

II. Principals of MRI

III. MRI Systems for Preclinical Imaging and Experimental Setup</P


This volume explores some of the most exciting recent advances in basic research on animal models of molecular pathology.

Key Features

  • This series provides a forum for discussion of new discoveries, approaches, and ideas
  • Contributions from leading scholars and industry experts
  • Reference guide for researchers involved in molecular biology and related fields


Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.


No. of pages:
© Academic Press 2011
Academic Press
eBook ISBN:
Hardcover ISBN:


Praise for the series:
"Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." --British Medical Journal

About the Editors

P. Michael Conn Editor

P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. Most recently, he has identified a new class of drugs, pharmacoperones, which act by regulating the intracellular trafficking of receptors, enzymes and ion channels. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn serve

Affiliations and Expertise

Texas Tech University Health Sciences Center, Lubbock, USA