Animal Models for the Study of Human Disease

1st Edition

Editors: P. Michael Conn
Hardcover ISBN: 9780124158948
eBook ISBN: 9780124159129
Imprint: Academic Press
Published Date: 22nd July 2013
Page Count: 1108
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Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse.

Key Features

  • Organized by disease orientation for ease of searchability
  • Provides information on locating resources, animal alternatives and animal ethics
  • Covers a broad range of animal models used in research for human disease


Biomedical and basic science researchers, graduate students and postdocs.

Table of Contents


List of Contributors

Part I: Ethics, Resources and Approaches

Chapter 1. Ethics in Biomedical Animal Research: The Key Role of the Investigator

Nature and Scope of the Chapter

The Subject Matter of Animal Research Ethics

Aspects of Animal Use and Care Relevant to Animal Research Ethics

Why Investigators are Uniquely Qualified to Engage in Ethical Assessment of Animal Research

Why Investigators Should Commit Themselves to Ethical Conduct of Animal Research

Why Investigators Play the Key Role in Assuring the Ethical Conduct of Animal Research Projects

Sources of Support and Guidance in Conducting Ethical Research

Developing Useful Ethical Guidelines

Fundamental Principles of Animal Research Ethics

Practical Ethical Guidelines for Investigators

Some Current Difficult Issues in Animal Research Ethics

General Suggestions for Investigators


Chapter 2. Access to Resources: A Model Organism Database for Humans


The Problem

The LAMHDI Solution

The Ideal Solution


Chapter 3. The Advent of the Golden Era of Animal Alternatives


Analytical Tools for the Detection of Food-Borne Disease

An in Vitro System to Assess Adverse Effects During Development


Noninvasive Imaging and Recording



Chapter 4. Environmental Enrichment for Animals Used in Research



Applied Science: Enrichment as a Welfare Tool

Basic Science: Enrichment and Animal Models

Enrichment and Experimental Variability

Environmental Enrichment Regulations

Implementing an Enrichment Plan



Part II: Vision

Chapter 5. Animal Models of Age-Related Macu


No. of pages:
© Academic Press 2013
Academic Press
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About the Editor

P. Michael Conn

P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. Most recently, he has identified a new class of drugs, pharmacoperones, which act by regulating the intracellular trafficking of receptors, enzymes and ion channels. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn serve

Affiliations and Expertise

Texas Tech University Health Sciences Center, Lubbock, USA


"...addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine."--Anticancer Research, February 2015

"…a very detailed textbook for researchers and laboratory animal veterinarians interested in getting an understanding of some of the animal models of human diseases.  The authors have done a good job of reviewing the numerous animal models in various physiological systems."--Laboratory Animal Practitioner, June 2014

"Conn presents this compendium on animal models in biomedical research, beginning with a section on ethical justifications, resources, and methodology to optimize the scientific value obtained from animal experiments. After this discussion, the volume is organized by disease group…The book aims to present successful animal models with the greatest homology to human systems.", February 2014

"This comprehensive textbook identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease…Organized by disease orientation for ease of searchability…Provides information on locating resources, animal alternatives and animal ethics."--Anticancer Research, 34, 2014

"…overall, the content (figures, tables and descriptions of the animal models and their significance) is excellent and should be considered a useful resource…Any laboratory animal research program, particularly those with an interest in working with multiple species of animal models, would benefit from having this book in the library."--
Lab Animal, February 2014