Animal Metamorphosis - 1st Edition - ISBN: 9780123859792, 9780123859808

Animal Metamorphosis, Volume 103

1st Edition

Serial Volume Editors: Yun-Bo Shi
eBook ISBN: 9780123859808
Hardcover ISBN: 9780123859792
Imprint: Academic Press
Published Date: 30th January 2013
Page Count: 456
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Table of Contents

Series Page



Chapter One. Developmental Checkpoints and Feedback Circuits Time Insect Maturation

1 Introduction

2 Checkpoint Controls for Progression of Development

3 Signals Converging on the PG

4 Shaping Discrete Ecdysone Pulses

5 Summary and Perspectives


Chapter Two. What Goes Up Must Come Down

1 Introduction

2 Historical Perspective

3 The Ecdysone Hierarchy I: Hormone Action at the Onset of Metamorphosis

4 The Ecdysone Hierarchy II: Early Response Genes

5 The Ecdysone Hierarchy III: Early-Late Response Genes and βftz-f1

6 Upstream of the Hormone: Ecdysone Synthesis in the Prothoracic Glands

7 Role Reversal: The Ecdysone Hierarchy Regulates Its Own Hormone

8 broad Controls a Key Component of Cellular Cholesterol Transport

9 DHR4 is a Key Mediator of PTTH Signaling

10 DHR3/E75-Mediated NO Signaling Is a Critical Player of Ecdysteroidogenesis

11 Other Transcription Factors with Known Expression in the Prothoracic Gland


Chapter Three. Hormonal Regulation of Insect Metamorphosis with Special Reference to Juvenile Hormone Biosynthesis

1 Introduction

2 Regulation of JH Biosynthesis

3 Molecular Action of JH on Insect Molting and Metamorphosis

4 Conclusion


Note Added in Proof

Chapter Four. The Role of Autophagy in Drosophila Metamorphosis

1 Introduction

2 Autophagy

3 Drosophila as a Model for Studying the Interface Between Steroid Signaling, Nutrition, and Growth During Development

4 Autophagy and Drosophila Development

5 Conclusions


Chapter Five. Metamorphosis in Teleosts

1 Introduction and Definitions

2 Metamorphic Diversity in Teleosts

3 Endocrine Controls of Teleost Metamorphosis

4 Local Mechanisms of Morphogenetic Changes

5 Conclusions



Chapter Six. Flatfish

1 Introduction

2 Genetic Basis of Flatfish Asymmetry

3 Metamorphic Asymmetry of the Brain, Sensory Organs, and Behavior

4 Asymmetric Craniofacial Remodeling and the Basis of Eye Migration

5 Flatfish Evolution: A Developmental Perspective


Chapter Seven. Neuroendocrinology of Amphibian Metamorphosis

1 Hormonal Control of Metamorphosis

2 Neuroendocrine Control of Metamorphosis

3 Role of the Neuroendocrine System in Mediating Environmental Influences on the Timing of Metamorphosis


Chapter Eight. Salamander Paedomorphosis

1 What is Paedomorphosis and Why Salamanders?

2 Paedomorphosis and Salamander Life History Variation

3 Hormonal Basis of Salamander Metamorphosis

4 Hormonal Basis of Paedomorphosis

5 Paedomorphosis in the Mexican Axolotl

6 Genomic Analysis of Salamander Metamorphosis and Paedomorphosis

7 Genetic Analysis of Paedomorphosis

8 The Link Between met1 and TH Regulation of Metamorphosis

9 What Genes Map to Metamorphic Timing QTL?

10 Synthesis: Evolution of Salamander Paedomorphosis


Chapter Nine. Metamorphosis in a Frog That Does Not Have a Tadpole

1 Introduction

2 Loss of Tadpole Structures in Frog Direct Development

3 Thyroid Hormone Dependency in Frog Direct Development

4 Mechanisms Underlying Tadpole Deletion

5 Precocious Appearance of Frog Features in Direct Developers

6 A Possible Role for Maternal Thyroid Hormone and Thyroid Hormone Receptor

7 Questions for the Future


Chapter Ten. High-Throughput Sequencing Will Metamorphose the Analysis of Thyroid Hormone Receptor Function During Amphibian Development

1 Introduction

2 Xenopus tropicalis Genomic Sequence and Annotation: Current State

3 TH and TR Regulating Network Using NGS-Based Transcriptome Analysis

4 TR Interactome

5 Conclusion


Chapter Eleven. Establishment of Intestinal Stem Cell Niche During Amphibian Metamorphosis

1 Introduction

2 Adult Epithelial Development During Intestinal Remodeling

3 Origin of Adult Stem Cells

4 Niche Essential for Adult Stem Cell Development

5 Signaling Pathways Involved in Establishment of Stem Cell Niche

6 Evolutionary Consideration and Prospect


Chapter Twelve. Developmental Programs and Endocrine Disruption in Frog Metamorphosis: The Perspective from Microarray Analysis

1 Introduction

2 Developmental Programs

3 Endocrine Disruption

4 Special Topics

5 Summary and Conclusions


Chapter Thirteen. Is Thyroid Hormone Signaling Relevant for Vertebrate Embryogenesis?

1 Introduction

2 Both TRs and Deiodinases are Expressed During Embryogenesis

3 Both T3 and T4 are Present During Embryonic Stages

4 What Roles Does TH Signaling Have During Early Development?

5 Does TH Signaling During Early Development Represent a New Scenario for Endocrine Disruption?

6 Conclusion


Chapter Fourteen. Thyroid Hormones and Postembryonic Development in Amniotes

1 Introduction

2 TH Signaling: The Basics

3 TH Controls Metamorphosis in Amphibians

4 TH-Regulated Metamorphosis is an Ancestral Chordate Character

5 Mammals

6 Sauropsids

7 Conclusion




This new volume of Current Topics in Developmental Biology covers recent progresses in our understanding of animal metamorphosis. Over a dozen of leading experts reviews studies ranging from morphological, molecular to genetic analyses of metamorphosis in a broad spectrum of animals, including insects, fish. Topics include molecular evolution in metamorphosis, the synthesis and function of hormones in regulating metamorphic timing and rate, regulation and function of nuclear hormone receptors, neuroendocrine control of metamorphosis, tissue specific metamorphic events such as autophagy and stem cell development, and applications of genome-wide analysis technologies for studying metamorphosis.

Key Features

  • First comprehensive review of the metamorphosis in diverse animal species by leading experts in the field
  • Covers a broad range of subjects: from morphological changes, molecular and genetic studies, to cutting-edge technologies for metamorphic studies; from systematic changes to tissue specific events, such as autophagy and stem cell development, which are areas of enormous interest in contemporary biomedical research
  • Serves as a reference book for undergraduate and graduate students in fields across biology and biomedicine


Researchers in cell, developmental, and molecular biology; genetics


No. of pages:
© Academic Press 2013
Academic Press
eBook ISBN:
Hardcover ISBN:


"Articles are concisely written and contain clear diagrams...each article has an abstract and is completed by an extensive bibliography, which also is a rich source of information for those interested in this promising complex of themes that are also of relevance for biomedical research."--Entomologie heute,Nov 01 2014

Ratings and Reviews

About the Serial Volume Editors

Yun-Bo Shi Serial Volume Editor