Angiotensin

Angiotensin

From the Kidney to Coronavirus

1st Edition - February 1, 2023

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  • Author: Paul Pilowsky
  • Paperback ISBN: 9780323996181

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Description

Angiotensin: From the Kidney to Coronavirus, a new volume in the Molecular Mediators in Health and Disease series, presents the communication role of the hormone in both health and disease states. Beyond the most common conditions, the book also explores the role of Angiotensin in infectious diseases, like COVID-19. Sections provide background to its discovery and role in homeostasis, focus on molecular biology aspects, including genetics and measurements of its associated proteins, describe the specific actions of angiotensin in normal physiology with different organ systems, survey different classes of drugs that act on the Renin-angiotensin-aldosterone system, cover non-angiotensin II peptides, and more. The final part of the book is dedicated to angiotensin’s role in disease states, making this the ideal reference for researchers in life sciences interested in understanding the physiological role of Angiotensin in a complete fashion. Research physicians will also benefit from the book’s complete coverage of organ systems and diseases where Angiotensin plays a key role.

Key Features

  • Covers the traditional disorders related to Angiotensin and new findings like its role in infectious diseases like COVID-19
  • Offers an overview of all important aspects of angiotensin, from discovery to clinical application, from physical and chemical properties to the physiological/cellular interaction
  • Expands on the role of angiotensin beyond the individual system the researcher is focusing, providing a comprehensive coverage of the additional effects at cell, tissue, organ, and system levels

Readership

Biological and biomedical sciences researchers at PhD level and above, Research Physicians in areas where Angiotensin plays a key role in disease states (cardiology, nephrology, cancer research)

Table of Contents

  • Part I - Introduction to angiotensins
    History of Angiotensin
    Angiotensin in Normal Biology

    Part II – Molecular biology of angiotensins
    Genes involved in the RAAS
    Measurement of angiotensins

    Part III – Angiotensin in organ function
    Angiotensin in blood vessels
    Angiotensin in the Kidney
    Angiotensin in Brain
    Angiotensin in the Eye
    Angiotensin in reproductive organs (e.g. testes, ovaries, sex-specificity)
    Angiotensin in the carotid body
    Angiotensin and aldosterone
    Angiotensin and the Lung

    Part IV - Angiotensin pharmacology
    Angiotensin-converting enzyme inhibitors (ACE-I)
    The angiotensin receptor blockers (ARB)
    Renin-inhibitors
    Angiotensin II as a therapeutic agent

    Part V – Non-angiotensin II peptides
    Non-angiotensin II peptides

    Part VI – Angiotensin in non-mammalian biology
    Angiotensin in other areas of biology
    Angiotensin in insects and other non-mammalian organisms

    Part VII - Angiotensin in Disease
    Adenomas of the renin angiotensin aldosterone system
    Angiotensin and cancer
    Angiotensin and Psychiatry
    Angiotensin and infectious disease

Product details

  • No. of pages: 450
  • Language: English
  • Copyright: © Academic Press 2023
  • Published: February 1, 2023
  • Imprint: Academic Press
  • Paperback ISBN: 9780323996181

About the Author

Paul Pilowsky

Paul M Pilowsky began BMedSci(Hons), BMBS, PhD his career as a graduate student investigating, inter alia, the role of brainstem and spinal cord pathways in the control of blood pressure with a focus on serotonin. His work has now been cited more than 5000 times and published in major Journals including the Journal of Neuroscience, the Journal of Comparative Neurology and the British Journal of Pharmacology. A hallmark of his work has been the adoption of, and combination of, novel approaches to address difficult questions. He pioneered the use of combining single cell electrophysiology in vivo with immunohistochemistry. His development of isotype selective monoclonal antibodies to phosphorylated tyrosine hydroxylase enabled the detection of tyrosine hydroxylase positive presympathetic neurons in the brainstem that had become excited. He was responsible for the initial development of a new medical school at Macquarie University in Sydney. His service to Neuroscience was recognised by the award of the Australian Neuroscience Medal. He mentored 26 graduate students to on-time completion, and mentored 24 post-Doctoral Fellows, many of whom now have their own established careers. In imagining this book, it was felt that a departure from the usual highly focussed text would be of interest. Hence, a multi-Author volume has been created that reveals the multiple facets of a neurotransmitter with very broad actions.

Affiliations and Expertise

Professor of Physiology, University of Sydney, Australia

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