Description

Understanding how angiogenesis "works" and how to control it will have massive implications on the management, treatments, and ultimately the prevention of many common (and not so common) diseases. Angiogenesis is the growth of new blood vessels and is an important natural process in the body. A healthy body maintains a perfect balance of angiogenesis modulators. In many serious disease states, however, the body loses control over angiogenesis. Diseases that are angiogenesis-dependent result when blood vessels either grow excessively or insufficiently.

Key Features

* Tried-and-tested techniques written by researchers that developed them, used them, and brought them to fruition * Provides the "builder's manual" for essential techniques--a one-stop shop that eliminates needless searching among untested techniques * Includes step-by-step methods for understanding the cell and molecular basis of wound healing, vascular integrin signaling, mechanical signaling in blood vessels, and vascular proteomics

Readership

Researchers in biochemistry, cell and molecular biology, physiology, oncology, cardiology and ophthalmology

Table of Contents

Inflammation and (lymph)angiogenesis Color-Coded Fluorescent Mouse Models of Cancer Cell Interactions with Blood Vessels and Lymphatics Bone-Marrow Derived Vascular Progenitors and Proangiogenic Monocytes in Tumors SCREENING PHAGE DISPLAY PEPTIDE LIBRARIES FOR VASCULAR TARGETED PEPTIDES Avian embryos: a model for the study of primary vascular assembly in warm-blooded animals Anti-cancer effects of VEGF inhibitors: insights from mouse models MOLECULAR IMAGING OF TUMOR VASCULATURE Proteomic mapping of the vascular endothelium as it exists in vivo for vascular targeting Development of Coronary Vessels Methods for evaluating uroplacental angiogenesis and their application using animal models Intravital Microscopic Investigation of Leukocyte Interactions with the Blood Vessel Wall Placental remodeling of the uterine vasculature An in vivo experimental model for postnatal vasculogenesis Assessment of arteriogenesis Methods to Study Myeloid Cell Roles in Angiogenesis

Details

No. of pages:
464
Language:
English
Copyright:
© 2008
Published:
Imprint:
Academic Press
eBook ISBN:
9780080921662
Print ISBN:
9780123743145

About the serial-volume-editor

David Cheresh

Affiliations and Expertise

The Scripps Research Institute, La Jolla, CA, USA

Reviews

Understanding how angiogenesis "works" and how to control it will have massive implications on the management, treatments, and ultimately the prevention of many common (and not so common) diseases. Angiogenesis is the growth of new blood vessels and is an important natural process in the body. A healthy body maintains a perfect balance of angiogenesis modulators. In many serious disease states, however, the body loses control over angiogenesis. Diseases that are angiogenesis-dependent result when blood vessels either grow excessively or insufficiently.