Androgens in Women: Too Much, Too Little, Just Right, An Issue of Endocrinology and Metabolism Clinics of North America

1st Edition, Volume 50-1 - January 29, 2021
Editor: Margaret E. Wierman
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 7 7 7 3 6 - 0
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 7 7 7 3 7 - 7

Guest edited by Dr. Margaret E. Wierman, this issue of Endocrinology and Metabolism Clinics will cover several key areas of interest related to Androgens in Women. This issue… Read more

Androgens in Women: Too Much, Too Little, Just Right, An Issue of Endocrinology and Metabolism Clinics of North America

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Guest edited by Dr. Margaret E. Wierman, this issue of Endocrinology and Metabolism Clinics will cover several key areas of interest related to Androgens in Women. This issue is one of four selected each year by our series Consulting Editor, Dr. Adriana Ioachimescu. Articles in this issue include but are not limited to: Hyperandrogenic Anovulation: Differential Diagnosis and Evaluation, Diagnosis of Polycystic Ovary Syndrome, Polycystic Ovary Syndrome: Ontogeny in Adolescence, Fertility Issues in Polycystic Ovarian Disease: A Systematic Approach, Management of Women with PCOS during Pregnancy, Genetics of PCOS, Cardiometabolic Risk in PCOS: Current Guidelines, Non Classical Congenital Adrenal Hyperplasia, Post-menopausal Hyperandrogenism: Evaluation and Treatment Strategies, Sexual Dysfunction in Women, Use of Testosterone in Postmenopausal women, Risks of Testosterone Therapy in Women, Non-Classic Congenital Adrenal Hyperplasia, and more.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Foreword
Preface
Hyperandrogenic Anovulation: Differential Diagnosis and Evaluation
Key points
Introduction
Clinical presentation of patients with hyperandrogenic anovulation
Disorders that present with hyperandrogenic anovulation
Laboratory evaluation
Radiologic evaluation
Summary
Clinics care points
Diagnosis of Polycystic Ovary Syndrome: Which Criteria to Use and When?
Key points
What is polycystic ovary syndrome ?
Diagnostic criteria
Limitations of the individual diagnostic criteria
Toward a biological basis for polycystic ovary syndrome classification
Summary
Clinics care points
Polycystic Ovary Syndrome: Ontogeny in Adolescence
Key points
Introduction: the challenge of studying nascent polycystic ovary syndrome
causes of polycystic ovary syndrome: a brief overview
Studies in girls at risk for developing polycystic ovary syndrome
Hypothetical model for the pubertal ontogeny of polycystic ovary syndrome
Summary
Clinics care points
Fertility Issues in Polycystic Ovarian Disease: A Systematic Approach
Key points
History
Diagnostic criteria
Pathophysiology
Polycystic ovary syndrome co-conditions that associate with fertility and their management
Ovulation induction in polycystic ovary syndrome
In vitro fertilization in polycystic ovary syndrome
Polycystic ovary syndrome and ovarian hyperstimulation syndrome
In vitro fertilization clinical outcomes
Summary
Clinics care points
Management of Women with Polycystic Ovary Syndrome During Pregnancy
Key points
Introduction
Perinatal outcomes
Placental contributions in adverse outcomes
Periconception, prenatal, and postpartum evaluation and management
Clinical care points
Genetics of Polycystic Ovary Syndrome: What is New?
Key points
Genetic variants confer risk for polycystic ovary syndrome
Is genetic architecture the same for all polycystic ovary syndrome subtypes?
Moving from genotype to functional mechanism—how does a risk variant cause polycystic ovary syndrome?
Mendelian randomization—what does it tell us?
Genetic risk scores—are they clinically useful for polycystic ovary syndrome diagnosis?
Precision medicine for polycystic ovary syndrome
Clinics care points
Cardiometabolic Risk in Polycystic Ovary Syndrome: Current Guidelines
Key points
Introduction
Overweight/obesity
Impaired glucose tolerance and type 2 diabetes mellitus
Dyslipidemia
Hypertension
Metabolic syndrome
Cardiovascular disease: subclinical atherosclerosis
Cardiovascular disease: venous thromboembolism
Cardiovascular disease events: myocardial infarction or stroke
Summary
Clinics care points
Postmenopausal Hyperandrogenism: Evaluation and Treatment Strategies
Key points
Introduction
Presenting signs and symptoms
Differential diagnosis
Diagnostic evaluation
Treatment benefits and options
Summary
Clinics care points
Use of Testosterone in Postmenopausal Women
Key points
Introduction
Overview of the physiology of testosterone in women
Current evidence
Discussion: prescribing testosterone
Summary
Clinics care points
Sexual Dysfunctions in Women: Are Androgens at Fault?
Key points
Introduction
History
Background
Examining evidence in support of a role of androgens in women’s sexual dysfunction
Examining evidence against androgen’s role in women’s sexual dysfunction
Sexual desire and dehydroepiandrosterone
Is any sex hormone at fault?
Needed research
How is sexual interest/arousal disorder assessed and treated?
Human sex response cycle
Summary
Clinics care points
Risks of Testosterone for Postmenopausal Women
Key points
Introduction
“Off-label” testosterone for hypoactive sexual desire disorder for postmenopausal women
Discussion
Summary
Clinics care points
Nonclassic Congenital Adrenal Hyperplasia: What Do Endocrinologists Need to Know?
Key points
Introduction
Epidemiology
Genetics of congenital adrenal hyperplasia
Clinical features of patients with congenital adrenal hyperplasia
Biochemistry of congenital adrenal hyperplasia: implication for diagnosis and disease monitoring
Management
Summary
Clinics Care Points