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Analytical Chemistry for Assessing Medication Adherence - 1st Edition - ISBN: 9780128054635, 9780128054598

Analytical Chemistry for Assessing Medication Adherence

1st Edition

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Authors: Sangeeta Tanna Graham Lawson
Paperback ISBN: 9780128054635
eBook ISBN: 9780128054598
Imprint: Elsevier
Published Date: 21st April 2016
Page Count: 156
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Table of Contents

  • Biographies
  • Preface
  • Acknowledgments
  • Chapter 1. Medication Adherence
    • Abstract
    • Introduction
    • What Is Medication Adherence?
    • Is Medication Adherence Really a Problem?
    • Consequences of Medication Nonadherence
    • Factors Affecting Medication Adherence
    • Clinical Practice Guidelines for the Improvement of Medication Adherence
    • Methods for Assessing Medication Adherence
    • Conclusions
    • References
  • Chapter 2. Opportunities and Challenges for Analytical Chemistry in the Assessment of Medication Adherence
    • Abstract
    • Introduction
    • Opportunities
    • Challenges
    • Biological Sample Matrices
    • Conclusions
    • References
  • Chapter 3. Analytical Chemistry Methods for the Assessment of Medication Adherence
    • Abstract
    • Introduction
    • Sample Preparation
    • Instrumental Analyses
    • Immunoassay (IA) Systems for Organic Active Ingredients
    • Chromatography-Based Methods for Organic Active Pharmaceutical Ingredients
    • Mass Spectrometry and Chromatography
    • Analytical Methods for Inorganic Active Pharmaceutical Ingredients
    • Polymerase Chain Reaction (PCR) Analysis
    • Test Facilities
    • Instrumentation for Service Provision
    • References
  • Chapter 4. Application of Bioanalytical Methods to Assess Medication Adherence in Clinical Settings
    • Abstract
    • Introduction
    • Cardiovascular Disease
    • Diabetes
    • Cancer
    • HIV/AIDS
    • Hepatitis C
    • Pain Management
    • Schizophrenia
    • Depression
    • Bipolar Disorder
    • Epilepsy
    • Malaria
    • Immunosuppression
    • Asthma
    • Other Infections
    • Other Clinical Applications
    • Conclusions
    • References
  • Chapter 5. Medication Adherence: Where Do We Go From Here?
    • Abstract
    • Introduction
    • Identifying Perceived Challenges
    • Ways Forward
    • Conclusions
    • References


The lack of adherence to medication is a growing public health problem worldwide and is costing many patients their good health and healthcare systems billions of dollars. A new volume in the Emerging Issues in Analytical Chemistry series, Analytical Chemistry for Assessing Medication Adherence introduces the concept of medication adherence/compliance and reports international perspectives on medication adherence while highlighting its importance. It then describes the opportunities for analytical chemistry to assess medication adherence and thereby provide an evidence base for clinicians to improve patient health outcomes. The authors highlight the strengths and weaknesses of each of the analytical techniques cited in addition to categorizing the findings in terms of the biological samples used to assess adherence and identifying methods to extract biological samples prior to analysis. The final chapter provides the authors’ perspective in this area, emphasising the importance of medication optimization for individual patients.

The Emerging Issues in Analytical Chemistry series is published in partnership with RTI International and edited by Brian F. Thomas. Please be sure to check out our other featured volumes:

  • Thomas, Brian F. and ElSohly, Mahmoud. The Analytical Chemistry of Cannabis: Quality Assessment, Assurance, and Regulation of Medicinal Marijuana and Cannabinoid Preparations, 9780128046463, December 2015.
  • Hackney, Anthony C. Exercise, Sport, and Bioanalytical Chemistry: Principles and Practice, 9780128092064, March 2016.
  • Rao, Vikram, Knight, Rob, and Stoner, Brian. Sustainable Shale Oil and Gas: Analytical Chemistry, Biochemistry, and Geochemistry Methods, 9780128103890, forthcoming September 2016.
  • Farsalinos, Konstantinos, et al. Analytical Assessment of e-Cigarettes: From Contents to Chemical and Particle Exposure Profiles, 9780128112410, forthcoming November 2016.

Key Features

  • Surveys the strengths, weaknesses, and appropriateness of existing instruments and techniques and points the way toward a program of therapeutic optimization
  • Brings together data scattered amongst professional journals and other sources in a single convenient volume
  • Presents the problem of adherence and the authors’ evaluation of possible solutions based on the analysis of patient bio-samples


Analytical chemists, clinical chemists, and medicinal chemists; pharmacologists; healthcare professionals including pharmacists, nurses, and clinicians; analytical instrument manufacturers; pharmaceutical scientists; regulatory officials and public health officials


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© Elsevier 2016
21st April 2016
Paperback ISBN:
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About the Authors

Sangeeta Tanna

Sangeeta Tanna

Sangeeta Tanna has a PhD in Pharmaceutics and is a Reader in Pharmaceutical Bioanalysis. Her expertise and research interests are the pharmaceutical bioanalysis and drug delivery fields. Her early research focused on developing instrumental methods for measuring the glucose-dependent delivery of insulin from a “smart” gel. This led to the development of microanalytical methodologies for the determination of therapeutic drugs from dried blood spots based on LC-MS, LC-MS/MS, and LC-HRMS studies. Applications of this work to patient healthcare include improved medications for newborn babies and to assess adherence to cardiovascular drug therapy for adult patients. She has a track record of published papers, invited international conference presentations, grants, and awards for this research.

Affiliations and Expertise

De Montfort University, Leicester, UK

Graham Lawson

Graham Lawson

Graham Lawson has a PhD in Analytical Chemistry and his expertise is in instrumental analysis, in disparate areas such as environmental exposure in the polymer industry, the identification of migrants from food packaging, and factors influencing drug delivery and clinical applications. The unifying themes are the detection of ultra-low levels of contamination in complex matrices and the protection of people from adverse exposures. Dr. Lawson’s current research interests include novel analytical techniques applied to dried blood spot analyses and to counterfeit drug detection.

Affiliations and Expertise

De Montfort University, Leicester, UK