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- Contributors to Volume 65
- Series Editor's Preface
- Chapter 1: Introduction to the Analysis of Bioactive Compounds in Marine Samples
- 1.1. Importance of bioactive compounds
- 1.2. Sources of bioactive compounds
- 1.3. Classes of bioactive compounds
- 1.4. General approaches for screening bioactive compounds
- Chapter 2: Prospection, Collection, and Preservation of Marine Samples
- 2.1. Introduction
- 2.2. Bioprospecting in extreme environments
- 2.3. Collection of marine samples
- 2.4. Sustainable production of bioactive compounds
- 2.5. Preservation of marine samples
- 2.6. Final considerations
- Chapter 3: Classical Methodologies for Preparation of Extracts and Fractions
- 3.1. Sample preparation of bioactive compounds from the marine environment
- 3.2. Final considerations
- Chapter 4: Green Analytical Methodologies for Preparation of Extracts and Analysis of Bioactive Compounds
- 4.1. Green extraction techniques to obtain bioactive compounds
- 4.2. Direct analysis of untreated samples to obtain bioactive compounds
- Chapter 5: Bioassays for Bioactivity Screening
- 5.1. Introduction
- 5.2. Screening models
- 5.3. Toxicity evaluation
- 5.4. Use of animals
- 5.5. Clinical trials
- 5.6. Conclusions and future perspectives
- Chapter 6: Vibrational Spectroscopy for Structural Characterization of Bioactive Compounds
- 6.1. Vibrational spectroscopy
- 6.2. Introduction to infrared (IR) and Raman spectroscopy
- 6.3. Selection rules in vibrational spectroscopy
- 6.4. Structure characterization by vibrational spectroscopy
- 6.5. Conclusion
- Chapter 7: Nuclear Magnetic Resonance Spectroscopy for Structural Characterization of Bioactive Compounds
- 7.1. Introduction
- 7.2. Proton resonances assignment
- 7.3. Establishment of carbon skeleton
- 7.4. Stereochemistry
- 7.5. Hyphenated NMR techniques
- 7.6. Quantitative NMR
- 7.7. Combined NMR techniques and different families of compounds
- 7.8. Revised structures
- Chapter 8: Mass Spectrometry for Determination of Bioactive Compounds
- 8.1. Introduction
- 8.2. Mass spectrometry (MS)
- 8.3. Tandem mass spectrometry (MSn)
- 8.4. Liquid chromatography–mass spectrometry (LC-MS)
- 8.5. Application of MS
- 8.6. Peptides
- 8.7. Alkaloids
- 8.8. Lipids
- 8.9. Conclusion
- Chapter 9: Chromatography Coupled to Various Detectors as a Tool for Separation and Determination of Bioactive Compounds
- 9.1. Introduction
- 9.2. One-Dimensional chromatography for bioactive compound analysis
- 9.3. Multidimensional chromatography for bioactive compounds discovery
- 9.4. Concluding remarks
- Chapter 10: Online Combination of Bioassays with Chemical and Structural Characterization for Detection of Bioactive Compounds
- 10.1. Introduction
- 10.2. High-throughput screening methods
- 10.3. High-resolution-based screening methods
- 10.4. Conclusions and perspectives
Seas and oceans offer a wide range of temperature, pressure, light and chemical conditions thus allowing a wide diversity of marine organisms from shallow coastal waters to the deep ocean. These resources can be used to obtain new products and develop services, and in turn help to provide solutions to the challenges that affect our planet, including offering a sustainable supply of food and energy, new industrial materials and processes, new bioactive compounds, and new health treatments. Marine compounds have been identified as having antibacterial, anticoagulant, antifungal, antimalarial, antiprotozoal, antituberculosis, and antiviral activities. The major sources of these bioactive compounds are marine sponges, coelenterates, and microorganisms, followed by algae, echinoderms, tunicates, molluscs, and bryozoans.
The discovery of bioactive compounds from marine samples is a hot topic considering the current need for sustainable use of marine resources. This book is a comprehensive overview of the analytical techniques employed in the discovery and characterization of bioactive compounds isolated from (all possible) marine samples and gives future perspectives of analytical methodologies. This overview includes an assessment of the sampling and preparation of extracts, the separation and isolation of bioactive compounds, their structural characterization and the application of bioassays in the discovery of bioactive compounds.
- Comprehensive coverage of analytical techniques and applications
- Clear diagrams to adequately support important topics
- Real examples of applications of analytical techniques in the search for new bioactive compounds
Marine scientists, analytical chemists, organic chemists, biologists, food scientists, and pharmaceutical scientists
- No. of pages:
- © Elsevier 2014
- 29th August 2014
- Hardcover ISBN:
- eBook ISBN:
Dr. Teresa Rocha-Santos graduated in Analytical Chemistry (1996) and obtained a PhD in Chemistry (2000), both at the University of Aveiro, Portugal. In 2001 she was awarded a prize for her PhD studies in the area of the urban environment.
She was an Assistant Professor at Instituto Piaget from 2000 to 2009. During this period she was the coordinator of the environmental chemistry graduation course (5 year degree) at Instituto Piaget. Currently, she is an Associate Professor at Instituto Piaget (from May 2009) and an integrated member at CESAM-University of Aveiro. Her research concentrates on the development of new analytical methodologies fit for purpose. She has published more than 80 peer-reviewed publications based on her research. Her work has been published in, among others, Trends in Analytical Chemistry, Science of the Total Environment, Journal of Hazardous Materials, Food Chemistry and Talanta.
ISEIT/Viseu-Instituto Piaget, Portugal
Prof. Armando C. Duarte (http://www.cesam.ua.pt/aduarte) graduated in Chemical Engineering (1977) at the University of Oporto (Portugal) and obtained a PhD in Public Health Engineering (1981) at the University of Newcastle-upon-Tyne (United Kingdom). In 2006, The Portuguese Science Foundation (www.fct.pt) awarded him a prize for Scientific Excellence and in 2013 he became a Member of the FCT Scientific Council for Natural and Environmental Sciences. He is a Professor of Environmental & Analytical Chemistry at the University of Aveiro (Portugal) since 1995, leader of a research group on the same subject, lecturer on Anaytical Quality Control subjects, and either supervising or co-supervising many PhD students, some of whom became members of staff, both as lecturers and researchers. His highly-interdisciplinary research spans areas of comprehensive environmental and analytical chemistry, qualimetrics and analytical quality assurance, but also includes the assessment of the relevance of new concepts and integration of different ideas into widely accepted frameworks, especially when applied to sustainability. He co-authored more than 450 peer-reviewed publications leading to an h-factor of 38.
University of Aveiro, Portugal
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