An Introduction to Biological Membranes
From Bilayers to Rafts
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An Introduction to Biological Membranes: From Bilayers to Rafts covers many aspects of membrane structure/function that bridges membrane biophysics and cell biology. Offering cohesive, foundational information, this publication is valuable for advanced undergraduate students, graduate students and membranologists who seek a broad overview of membrane science.
Key Features
- Brings together different facets of membrane research in a universally understandable manner
- Emphasis on the historical development of the field
- Topics include membrane sugars, membrane models, membrane isolation methods, and membrane transport
Readership
Graduate students, postdoctoral fellows, and researchers in biology, cell biology, biochemistry, and biophysics
Table of Contents
- Dedication
Preface
1. Introduction to Biological Membranes
A What is a Biological Membrane?
B General Membrane Functions
C Eukaryote Cell Structure
D Size of Domains
E Basic Composition of Membranes
Summary
References
2. Membrane History
A Oil On Water: Interface Studies
B The Lipid Bilayer Membrane
Summary
References
3. Water and the Hydrophobic Effect
A Water – Strength in Numbers
B Structure of Water
C Properties of Water – No Ordinary Joe
D Surface Tension
E The Hydrophobic Effect
Summary
References
4. Membrane Lipids: Fatty Acids
A What are Lipids?
B Why are there so Many Different Lipids?
C Lipid Classification Systems
D Fatty Acids
Summary
References
5. Membrane Polar Lipids
A Bonds Connecting to Acyl Chains
B Phospholipids
C Sphingolipids
D Sterols
E Membrane Lipid Distribution
F Plant Lipids
G Membrane Lipids Found in Low Abundance
Summary
References
6. Membrane Proteins
A Introduction
B The Amino Acids
C How Many Membrane Protein Types are there?
Summary
References
7. Membrane Sugars
A Introduction
B Glycolipids
C Glycoproteins
D GPI-Anchored Proteins
Summary
References
8. From Lipid Bilayers to Lipid Rafts
A Development of Membrane Models
B The Danielli-Davson Pauci-Molecular Model
C The Robertson Unit Membrane Model
D Benson and Green’s Lipoprotein Subunit Models
E The Singer-Nicolson Fluid Mosaic Model
F Simons’ Lipid Raft Model
Summary
References
9. Basic Membrane Properties of the Fluid Mosaic Model
A Size and Time Domains
B Membrane Thickness
C Membrane Asymmetry
D Lateral Diffusion
E Lipid Trans-membrane Diffusion (Flip-Flop)
F Lipid Melting Behavior
G Membrane ‘Fluidity’
Summary
References
10. Lipid Membrane Properties
A Complex Lipid Interactions
B Non-Lamellar Phases
C Lipid Phase Diagrams
D Lipid–Protein Interactions
E Lipid Interdigitation
Summary
References
11. Long-Range Membrane Properties
A Membrane Bilayer Lipid Packing
B Membrane Protein Distribution
C Imaging of Membrane Domains
D Homeoviscous Adaptation
Summary
References
12. Membrane Isolation Methods
A Introduction
B Breaking Open the Cell: Homogenization
C Membrane Fractionation: Centrifugation
D Membrane Fractionation: Non-Centrifugation Methods
E Membrane Markers
Summary
References
13. Membrane Reconstitution
A Detergents
B Membrane Protein Isolation
C Membrane Lipid Isolation
D Model Lipid Bilayer Membranes – Liposomes
E Membrane Reconstitution
F Lipid Rafts
Summary
References
14. Membrane Transport
A Introduction
B Simple Passive Diffusion
C Facilitated Diffusion
D Active Transport
E Ionophores
F Gap Junctions
G Other Ways to Cross the Membrane
Summary
References
15. Membranes and Human Health
A Liposomes as Drug-Delivery Agents
B Effect of Dietary Lipids on Membrane Structure/Function
Summary
References
Appendix A. Chronology of Membrane Studies
Index
Product details
- No. of pages: 378
- Language: English
- Copyright: © Elsevier Science 2013
- Published: April 20, 2013
- Imprint: Elsevier Science
- eBook ISBN: 9780080931289
- Hardcover ISBN: 9780444521538
About the Author
William Stillwell
Dr. Stillwell was a faculty member at Indiana University-Purdue University Indianapolis for 32 years where he taught a senior level course in Biological Chemistry and a graduate level course in Biological Membranes. He also led an active research lab on the effect of omega-3 fatty acids on model membrane structure and function. He has published 140 papers and 400 abstracts on membranes. He has been an Associate Editor of Chemistry and Physics of Lipids. He retired in 2010 and now maintains Professor Emeritus status.
Affiliations and Expertise
Faculty member at Indiana University-Purdue University Indianapolis
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