Amyloid, Prions, and Other Protein Aggregates, Part B - 1st Edition - ISBN: 9780121828172, 9780080522548

Amyloid, Prions, and Other Protein Aggregates, Part B, Volume 412

1st Edition

Serial Volume Editors: Ronald Wetzel Indu Kheterpal
Hardcover ISBN: 9780121828172
eBook ISBN: 9780080522548
Imprint: Academic Press
Published Date: 6th October 2006
Page Count: 430
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Table of Contents

Characterization of protein deposition in vivo and ex vivo.

Chapter 1: PMCA for diagnosis and prion propagation studies. Chapter 2: Fractionation of prion protein aggregates by asymmetrical flow field-flow fractionation. Chapter 3: Analysis of Amyloid Aggregates Using Agarose Gel Electrophoresis. Chapter 4: Characterization of Systemic Amyloid Deposits by Mass Spectrometry. Chapter 5: Proteomics of Polyglutamine Aggregates. Chapter 6: Merger of Laser Capture Microdissection and Mass Spectrometry: A Window into the Amyloid Plaque Proteome. Chapter 7: MALDI MS Imaging of Amyloid. Chapter 8: Imaging polyglutamine deposits in brain tissue. Chapter 9: X-34 labeling of abnormal protein aggregates during the progression of Alzheimer’s disease. Chapter 10: Visualizing Pathology Deposits in the Living Brain of Alzheimer’s Disease Patients. Chapter 11: Micro-Imaging of Amyloid in Mice

Cell and animal models of amyloid formation and toxicity

Chapter 12: An efficient protein transformation protocol for introducing prions into yeast. Chapter 13: Screening for genetic modifiers of amyloid toxicity in yeast. Chapter 14: Searching for anti-prion compounds: Cell-based high-throughput in vitro assays and animal testing strategies. Chapter 15: A Drosophila Model of Alzheimer’s Disease. Chapter 16: A C. elegans model of polyglutamine disease.

Computational Approaches and Theory

Chapter 17: Nucleation: the Connections between Equilibrium and Kinetic Behavior. Chapter 18: Computational Approaches to Amyloid beta Fibril Core Structure. Chapter 19: Amyloid beta-protein aggregations: Ab initio discrete molecular dynamics approaches. Chapter 20: Computational approaches to fibril structure and formation


Description

Characterization of protein deposition in vivo and ex vivo.

Chapter 1: PMCA for diagnosis and prion propagation studies. Chapter 2: Fractionation of prion protein aggregates by asymmetrical flow field-flow fractionation. Chapter 3: Analysis of Amyloid Aggregates Using Agarose Gel Electrophoresis. Chapter 4: Characterization of Systemic Amyloid Deposits by Mass Spectrometry. Chapter 5: Proteomics of Polyglutamine Aggregates. Chapter 6: Merger of Laser Capture Microdissection and Mass Spectrometry: A Window into the Amyloid Plaque Proteome. Chapter 7: MALDI MS Imaging of Amyloid. Chapter 8: Imaging polyglutamine deposits in brain tissue. Chapter 9: X-34 labeling of abnormal protein aggregates during the progression of Alzheimer’s disease. Chapter 10: Visualizing Pathology Deposits in the Living Brain of Alzheimer’s Disease Patients. Chapter 11: Micro-Imaging of Amyloid in Mice

Cell and animal models of amyloid formation and toxicity

Chapter 12: An efficient protein transformation protocol for introducing prions into yeast. Chapter 13: Screening for genetic modifiers of amyloid toxicity in yeast. Chapter 14: Searching for anti-prion compounds: Cell-based high-throughput in vitro assays and animal testing strategies. Chapter 15: A Drosophila Model of Alzheimer’s Disease. Chapter 16: A C. elegans model of polyglutamine disease.

Computational Approaches and Theory

Chapter 17: Nucleation: the Connections between Equilibrium and Kinetic Behavior. Chapter 18: Computational Approaches to Amyloid beta Fibril Core Structure. Chapter 19: Amyloid beta-protein aggregations: Ab initio discrete molecular dynamics approaches. Chapter 20: Computational approaches to fibril structure and formation

Key Features

  • Presents detailed protocols
  • Includes troubleshooting tips
  • Provides coverage on structural biology, computational methods, and biology

Readership

Biochemists, cell biologists, neuroscientists, and related fields engaged in protein research.


Details

No. of pages:
430
Language:
English
Copyright:
© Academic Press 2006
Published:
Imprint:
Academic Press
eBook ISBN:
9780080522548
Hardcover ISBN:
9780121828172

About the Serial Volume Editors

Ronald Wetzel Serial Volume Editor

Affiliations and Expertise

University of Tennessee Medical Center, Knoxville, U.S.A.

Indu Kheterpal Serial Volume Editor