Aminopyridines and Similarly Acting Drugs: Effects on Nerves, Muscles and Synapses

Aminopyridines and Similarly Acting Drugs: Effects on Nerves, Muscles and Synapses

Proceedings of a IUPHAR Satellite Symposium in Conjunction with the 8th International Congress of Pharmacology, Paris, France, July 27-29, 1981

1st Edition - April 29, 1982

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  • Editors: P. Lechat, S. Thesleff, W. C. Bowman
  • eBook ISBN: 9781483150437

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Description

Aminopyridines and Similarly Acting Drugs: Effects on Nerves, Muscles and Synapses presents the proceedings of a IUPHAR Satellite Symposium in conjunction with the eighth International Congress of Pharmacology held in Paris, France on July 27-29, 1981. The book contains papers on the effects of aminopyridines on ionic currents in excitable membranes; the effects of aminopyridines on synaptic transmission; and the effects of aminopyridines on the release of chemical transmitters. The text also presents papers on some differences in the blockade of potassium permeabilities by apamin and the aminopyridines; the miscellaneous actions of aminopyridines and related compounds; and the effects of aminopyridines on the skeletal, smooth and cardiac muscle. The clinical applications of aminopyridines and further miscellaneous actions of aminopyridines and related compounds are also considered.

Table of Contents


  • List of Participants

    Scientific Sessions

    Historical review

    Aminopyridines and Ionic Currents in Excitable Memebranes

    General review on potassium currents in exitable membranes of nerve and muscle

    Effects of Aminopyridines on Potassium currents of the Nodal Membrane

    Properties and Physiological Roles of K+ Currents in Frog Myelinated Nerve Fibres as Revealed by 4-aminopyridine

    Effects of Aminopyridines on Ionic Currents and Ionic Channel Noise in Unrnyelinated Axons

    3- and 4-Aminopyridine in Synaptic Transmission at the Squid Giant Synapse

    Discussion

    Aminopyridines and Synaptic Transmission

    Lectures

    General Principles of Synaptic Transmission

    Effects of Aminopyridines on Neuromuscular Transmission

    Effects of 4-Aminopyridine on Transmission in Excitatory and Inhibitory synapses in the spinal cord

    The Influence of 4-Aminopyridine on Parasympathetic Transmission

    Discussion

    Aminopyridines and the Release of Chemical Transmitters: Contrast with Apamin

    Lectures

    Structure-Activity Relationships Amongst Aminopyridines

    Aminopyridine as a tool to Investigate the Mechanism of Acetylcholine Release at the Nerve Electroplaque Junction

    Intramembrane Particles Changes: A Constant Feature of the Release Mechanism

    Effect of Aminopyridine and Related Drugs on Catecholamine Release

    Some Differences in the Blockade of Potassium Permeabilities by Apamin and the Aminopyridines

    Discussion

    Miscellaneous Actions of Aminopyridines and Related Compounds: Poster Communications

    The action of Morphine Dependence on the Convulsive Effect of 4-Aminopyridine and Other Drugs

    Antagonism to Dopaminergic Stereotypy, and Convulsant and Hypertensive Effects by 2-Amino-4-Methylpyridine

    4-Aminopyridine (4AP) Enhances Acetylcholine Output from the Rat Cerebral Cortex in Vivo

    4-Aminopyridine as a Tool to Elucidate Different Actions of Botulinum A and Tetanus Toxin at the Mouse Neuromuscular Junction

    Antagonism of the Myoneural Activity of Antibiotics, Local Anesthetics and General Anesthetics by 4-APYR

    Increased Tetanic Fade Produced by 3,4-Diaminopyridine in the Presence of Neuromuscular Blocking Agents

    Effect of 4-Aminopyridine on the Electrical Activity of the Hippocampus and the Cerebellum

    Cardiac Effects of 4-Minoquinoline on Mammalian and Amphibian Isolated Preparations. An Electrophysiological study

    Facilitatory Effects of Aminopyridines on Synaptic Transmission in the Sixth Abdominal Ganglion of the Cockroach

    The Effect of 3-, 4-AP and 3,4-DAP on the Evoked Activity of the Pyramidal Cell Layer (CA 1,2) of the Hippocampus. An in Vitro Study

    Fast and Slow Automatic Activity of Squid Giant Axons Induced by 4-Aminopyridine

    The Ability of 4-AP and 3,4-DAP to Cross the Blood-Brain Barrier can Account for their Difference in Tonicity

    Action of 4AP and TEA on Presynaptic Currents in Mammalian Motor Endings

    Protein Synthesis in Brain Subcellular Fractions. Effect of 4-Aminopyridine

    Effects of 4-Hydroxypyridine on Transmitter Release at the Neuromuscular Junction

    4-Aminopyridine Analogs of Novel Chemical Structure

    Excitatory Action of Imidazole on Evoked Transmitter Release from the Phrenic Nerve and on Potassium-Stimulated 45Ca Uptake by Synaptosomes in the Rat

    Aminopyridine Effects on Molecular Models in Myopathic States

    Effects of Pyridine on the Frog Rectus Abdominis Muscle

    4-Aminopyridine and Presynaptic Modulation of Transmitter Release in Aplysia

    Naloxone, 4-Aminopyridine and Physostigmine as Antagonists of Morphine in Rabbits

    Anti-Curare Action of 4-Aminopyridine and 4-Aminopyridine-Like Substances

    4-Aminopyridine Reversal of Morphine Analgesia

    4-Aminopyridine as Antagonist of the Cardiovascular and Neuromuscular Depressant Effects of Kanamycin in Rats

    Further Actions of Aminopyridines on Muscle and Nerve: Short Communications

    Effects of 4-Aminopyridine on Mammalian Peripheral and Central Neurones

    Interactions of Aminopyridines and Related Compounds with Ionic Channels in the Isolated Cockroach Axon

    4-aminopyridine-Induced Alteration in the Receptive Field of Cuneate and Gracile Neurones

    Effect of 4-Aminopyridine on the Desensitisation of the Rat Diaphragm Caused by Carbachol

    The Effects of 4-Aminopyridine on Neuromuscular Block Produced by Succinyldicholine

    Chemical Modulators: Their Molecular Characteristics and Kinetics of Actions

    Discussion

    Aminopyridines and Skeletal, Smooth and Cardiac Muscle

    Lectures

    Effects of 4-Aminopyridine on Contractile Properties of Skeletal Muscle

    Effects of 4-Aminopyridine on Cardiac Muscle

    Oral communications

    Effects of 4-Aminopyridine on Isometric Force - [Ca++] - Relations in Mammalian Slow and Fast Twitch Skinned Muscle Fibres

    4-Aminopyridine and Outward Membrane Currents in Rat Uterine Smooth Muscle at Various Stages of Pregnancy

    Effects of 4-Aminopyridine on Membrane Currents in the Pace-Maker Voltage Range of Sheep Cardiac Purkinje Fibres

    Is the Cardiotonic Effect of Aminopyridines and Aminopyrimidines in Vitro a Consequence of Increased Extracellular pH?

    Discussion

    Clinical Applications of Aminopyridines

    Lectures

    Therapeutic Applications of Aminopyridines in Diseases of Neuromuscular Transmission

    Use of 4-Aminopyridine in Human Botulism

    Therapeutic Applications of 4-Aminopyridine in Anaesthesia

    Oral communications

    Effects of 3,4-Diaminopyridine in Cynomolgus Monkeys Poisoned with Type A Botulinum Toxin

    Discussion

    Further Miscellaneous Actions of Aminopyridines and Related Compounds: Short Communications

    Oral communications

    Potassium Channel Block by S-Methylthiouronium, a Pharmacological Analogue of 4-Aminopyridine

    Differences in Actions of 4-Aminopyridine and 4-Methyl-2-Aminopyridine

    Effects of Aminopyridines in Avian Muscular Dystrophy

    Comparison of the Actions of Dendrotoxin, a Facilitatory Neurotoxin, and 3,4-Diaminopyridine on Neuromuscular Transmission

    Effects of Aminopyridines on Parasympathetic Neuroeffector Transmission in the Heart

    Effects of 4-Aminopyridine on Endocrine Cells

    An Electroencephalographic Study of 4-Aminopyridine in Conscious Volunteers

    Discussion

    Conclusions

    Index

Product details

  • No. of pages: 362
  • Language: English
  • Copyright: © Pergamon 1982
  • Published: April 29, 1982
  • Imprint: Pergamon
  • eBook ISBN: 9781483150437

About the Editors

P. Lechat

S. Thesleff

W. C. Bowman

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