Amines and Schizophrenia

Amines and Schizophrenia

1st Edition - January 1, 1967

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  • Editors: Harold E. Himwich, Seymour S. Kety, John R. Smythies
  • eBook ISBN: 9781483157092

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Amines and Schizophrenia is a collection of articles that survey and discuss the biochemical basis present, if any, in schizophrenia, focusing on the role of certain amines. The book discusses certain hypotheses dealing with the field of bio-chemistry as the basis for diseases such as schizophrenia, manic-depressive psychosis, and related diseases. Discussions start with the properties of mescaline, because the psychotic effect of the drug has some aspects similar to that of a schizophrenic syndrome. One paper examines the presence of certain amines, such as norepinephrine, dopamine, and serotonin in the brain, including their role in the synaptic transmission of nerve impulses in the central nervous system. Other papers review the role of derangements of tryptophan metabolism in psychotic behavior; the metabolic interrelationships of tryptophan and methionine in mental illness; and the results obtained with psychomimetic and non-psychomimetic congeners of three classes of indoleamines including LSD. The book gives more details on the actions of various biological amines on single neurons in the limbic system of the brain. The text also evaluates the use of hallucinogenic drugs in considering their heuristic value in the study of the biochemical basis of mental function. The selection will prove relevant for psychologists, psychiatrists, drug researchers, pharmacologists, and chemical laboratory workers and technicians.

Table of Contents

  • Preface


    Structure-activity Relationships of Mescaline

    New Developments in the Investigation of the Relationship of 3,4-dimethoxyphenylethylamine to Schizophrenia

    Para-O-methylation of Dopamine in Schizophrenic and Normal Individuals

    Studies of Amines in Normal and Schizophrenic Subjects

    3,4-Dimethoxyphenylethylamine in Schizophrenia

    General Discussion

    Studies on the Association of Urinary Tryptamine with the Excretion of Amino Acids and 17-ketosteroid Hormones in Schizophrenic Patients

    Tryptophan Metabolism in Psychoses

    Metabolic Interrelationships of Tryptophan and Methionine in Relation to Mental Illness

    Studies on Periodic Catatonia

    General Discussion

    Comparative Neurophysiological Studies of Psychotomimetic N-dimethylamines and N-diethylamines and their non-psychotomimetic Congeners Devoid of the N-dimethyl or N-diethyl Configurations

    Gas Chromatographic Analysis of Some Psychoactive Indole Bases

    Tryptophan Metabolism in Mental Illness

    Hallucinogenic Amines and Schizophrenia (with a Brief Addendum on N-dimethyltryptamine)

    Factors Influencing S-adenosylmethionine Levels in Mammalian Tissues

    General Discussion

    The Actions of Various Biological Amines on Single Neurones in the Limbic System

    A Quantum-chemical Correlate of Hallucinogenesis

    Studies on Homocystinuria

    General Discussion

    Summary. The Hypothetical Relationships between Amines and Mental Illness; a Critical Synthesis


Product details

  • No. of pages: 300
  • Language: English
  • Copyright: © Pergamon 1967
  • Published: January 1, 1967
  • Imprint: Pergamon
  • eBook ISBN: 9781483157092

About the Editors

Harold E. Himwich

Affiliations and Expertise

Galesburg State Research Hospital

Seymour S. Kety

John R. Smythies

John Smythies is a neuropsychiatrist and neuroscientist and has made significant contributions to both these disciplines. Together with Humphrey Osmond he developed the first biochemical theory of schizophrenia—the transmethylation hypothesis. This has recently come back into focus following the finding that DNA methylation is abnormal in schizophrenia. He has made extensive contributions to knowledge in a number of fields including the neuropharmacology of psychedelic drugs; the functional neuroanatomy of synapses with particular regard to the role of synaptic plasticity, endocytosis and redox factors ; the role in the brain of orthoquinone metabolites of catecholamines; and, in particular, theories of brain-consciousness relations. More recently he has worked on epigenetic processes in information processing in the brain, and the functional neuroanatomy of the claustrum. Smythies has served as President of the International Society of Psychoneuroendocrinology from 1970-1974, Consultant to the World Health Organization from 1963-1968, and Editor of the International Review of Neurobiology from 1958-1991. He was elected a member of the Athenaeum in 1968. He has published over 240 scientific papers and sixteen books. Smythies has held positions as the Charles Byron Ireland Professor of Psychiatric Research at the University of Alabama Medical Center at Birmingham, Visiting Scholar at the Center for Brain and Cognition, University of California San Diego, and Senior Research Fellow at the Institute of Neurology, University College London.

Affiliations and Expertise

The Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts

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