Alzheimer's Disease

Alzheimer's Disease

Understanding Biomarkers, Big Data, and Therapy

1st Edition - August 28, 2021

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  • Author: Ahmed Moustafa
  • Paperback ISBN: 9780128213346
  • eBook ISBN: 9780128213353

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Description

Nearly 44 million people have Alzheimer’s or related dementia worldwide, according to the Alzheimer’s Disease International organization. That number is expected to double every 20 years. Unlike other books on the market, Alzheimer's Disease: Understanding Biomarkers, Big Data, and Therapy covers recent advancements in cognitive, clinical, neural, and therapeutic aspects of Alzheimer’s and other forms of dementia.First, readers are introduced to cognitive and clinical studies, focusing on the different types of memory impairment, past and future thinking. This includes the prevalence of depression, its relationship to other symptoms, and the quality of life for those with Alzheimer’s disease. In addition, the book discusses recent studies on memory dysfunction in advanced-stage Alzheimer’s disease, in comparison to early-stage, including a chapter on the underlying factors in the transition from mild cognitive impairment to Alzheimer’s diagnosis. Following this section, the book presents recent studies on the role of different cortical and subcortical structures in the development of various symptoms in Alzheimer’s disease, as well as different neural biomarkers underlying the development and treatment of the disease. In the last section of the book, therapeutic aspects of Alzheimer’s disease, focusing on behavioral and pharmacological treatments of sleep disorders, memory problems, and depression, are reviewed. The book aids readers in understanding the advances in research and care, making it a prime tool for all clinicians, psychologists, researchers, neurologists, and caregivers of dementia patients.

Key Features

  • Reviews recent developments of cognitive and clinical studies
  • Covers factors underlying the transition from mild cognitive impairment to Alzheimer’s disease
  • Discusses different neural biomarkers underlying the development and treatment of Alzheimer’s disease
  • Provides a comparison of the effectiveness of various types of treatments

Readership

Advanced students and researchers in cognitive and behavioral neuroscience, psychology, psychiatry, psychotherapy, neurology

Table of Contents

  • Part I: Mental Health in Dementia
    1. Measures of depression in Alzheimer’s disease
    Ahmed A. Moustafa, Wafa Jaroudi, Lily Bilson and Mohamad El Haj
    2. The nature of depression in dementia: A narrative review
    Ahmed A. Moustafa, Phoebe Bailey, Wafa Jaroudi, Lily Bilson and Mohamad El Haj
    3. Stress and anxiety in dementia
    Ahmed A. Moustafa, Shimaa Adel Heikal and Wafa Jaroudi

    Part II: Advanced Topics in Dementia Research
    4. Alzheimer's disease in the pupil: Pupillometry as a biomarker of cognitive processing in Alzheimer’s Disease
    Ahmed A. Moustafa and Mohamad El Haj
    5. Cognitive and neural correlates of vitamin D deficiency: Focus on healthy aging and Alzheimer’s Disease
    Ahmed A. Moustafa, Wafa Jaroudi and Abdrabo Soliman
    6. The effect of Alzheimer’s Disease on the thalamus
    Ahmed A. Moustafa and Rasu Karki
    7. Using big data methods to understand Alzheimer's Disease
    Ahmed A. Moustafa, Samuel L. Warren and Hany Alashwal
    8. Operational aspects of deep learning solutions for Alzheimer's Disease
    Ahmed A. Moustafa, Dustin van der Haar and Samuel L. Warren

    Part III: Treatment of Dementia
    9. Treatment of depression in Alzheimer's Disease
    Ahmed A. Moustafa, Lily Bilson and Wafa Jaroudi
    10. Developing a vulnerability to negative affect scale for music interventions for people with dementia
    Ahmed A. Moustafa, Sandra Garrido and Wafa Jaroudi
    11. Using music to improve mental health in people with dementia
    Ahmed A. Moustafa, Wafa Jaroudi and Sandra Garrido
    12. The efficacy of Donepezil for the treatment of Alzheimer's Disease
    Ahmed A. Moustafa and Samuel L. Warren

Product details

  • No. of pages: 254
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: August 28, 2021
  • Imprint: Academic Press
  • Paperback ISBN: 9780128213346
  • eBook ISBN: 9780128213353

About the Author

Ahmed Moustafa

Dr. Ahmed A. Moustafa is an associate professor in Cognitive and Behavioral Neuroscience at the Marcs Institute for Brain, Behavior, and Development, and in the School of Social Sciences and Psychology, Western Sydney University. He is trained in computer science, psychology, neuroscience, and cognitive science. His early training took place at Cairo University in mathematics and computer science. Before joining Western Sydney University as a lab director, he spent 11 years in America studying psychology and neuroscience. He researches computational and neuropsychological studies of addiction, schizophrenia, Parkinson’s disease, PTSD, and depression. He has published more than 150 papers in high-ranking journals including Science, PNAS, Journal of Neuroscience, Brain, Neuroscience and Biobehavioral Reviews, and Neuron.

Affiliations and Expertise

Associate Professor, Cognitive and Behavioral Neuroscience, Western Sydney University, Sydney, NSW, Australia; Department of Human Anatomy and Physiology, the Faculty of Health Sciences, University of Johannesburg, South Africa; Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland; School of Psychology and Marcs Institute for Brain and Behaviour, Western Sydney University, Sydney, NSW, Australia

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