Aliphatic and Polyhalogenated Carcinogens - 1st Edition - ISBN: 9780120593231, 9781483216010

Aliphatic and Polyhalogenated Carcinogens

1st Edition

Structural Bases and Biological Mechanisms

Authors: Yin-Tak Woo David Y. Lai Joseph C. Arcos
eBook ISBN: 9781483216010
Imprint: Academic Press
Published Date: 25th April 1985
Page Count: 618
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Description

Chemical Induction of Cancer: Structural Bases and Biological Mechanisms, Volume IIIB: Aliphatic and Polyhalogenated Carcinogens covers environmentally and occupationally significant carcinogens of industrial origins.
The book discusses the structure-activity relationships, metabolism, and environmental significance of the halogenated linear alkanes and alkenes and the halogenated cycloalkanes; and cycloalkene pesticides, biphenyls, and related aromatics. The text also describes the structure-activity relationships, metabolism, and environmental significance of the halogenated phenoxy acids, aromatic ethers, dibenzofurans, and dibenzo-p-dioxins; and ethylene glycol, diethylene glycol, dioxane, and related compounds. The structure-activity relationships, metabolism, and environmental significance of phenols and phenolic compounds; nitroalkanes and nitroalkenes; and acetamide, dimethylcarbamyl chloride, and related compounds thiocarbonyl compounds are also encompassed. The book further tackles the structure-activity relationships, metabolism, and environmental significance if fatty acids, detergents, and other surfactants with oncogenic potential. The text then looks into the effect of chemical reactivity, molecular geometry, and metabolism on carcinogenic activity.
Chemists, geneticists, and those involved in cancer research will find the book invaluable.

Table of Contents


General Plan

Preface

Acknowledgments

Part III (Continued) Structure-Activity Relationships of Chemical Carcinogens. Effect of Reactivity, Molecular Geometry, and Metabolism on Carcinogenic Activity

5. Structure-Activity Relationships

5.2.Nonconjugated Organic Compounds

Updating Notes

Notes Added after Completion of Section 5.2.2.1

Notes Added after Completion of Section 5.2.2.2

Notes Added after Completion of Section 5.2.2.3

Notes Added after Completion of Section 5.2.2.4

Notes Added after Completion of Section 5.2.2.5

Notes Added after Completion of Section 5.2.2.7

Notes Added after Completion of Section 5.2.2.8

Notes Added after Completion of Section 5.2.2.9

Appendix I. Novel Types of Carcinogens

Carbazole

Anthanthrene

Benzene

Furylfuramide (Furfurylamide; AF-2)

Niridazole

4-Nitropyridine N-Oxide

Quinoline and Its Derivatives

Quinoxaline 1,4-Dioxide

Benzoyl Chloride and Other Acylating Agents

Acetone Oxime (Acetoxime)

Pronamide

ZAMI 1305

Hycanthone

1,3-Butadiene

Aniline and Azobenzene

4-Aminoazobenzene

References to Appendix I

Appendix II. Update to Vol. I: New Developments in Short-Term Tests for Carcinogenicity: Genetic Toxicology Testing

Introduction

Application of Genotoxicity Data to Human Health Effects

Development of Genetic Toxicology Bioassays

Application of Short-Term Bioassays to the Assessment of Human Cancer and Mutation Risk

Concluding Remarks

References to Appendix II

Appendix III. Update to Vol. I: New Perspectives in Cancer Research Data Search: Modern Computer-Based Information Systems

Introduction

Computer Databases Useful for Cancer Research

Automatic Selective Dissemination of Information

Special Cancer Databases

Other Databases of Interest for Cancer Research

Special Publications That Provide Useful Information to Cancer Researchers

Conclusion

References to Appendix III

Appendix IV. Update to Vol. IIA: Metabolic Activation by One-Electron and Two-Electron Oxidation in Aromatic Hydrocarbon Carcinogenesis

Introduction

Enzymology of One-Electron and Two-Electron Oxidation

Two-Electron Oxidation or Monooxygenation of Aromatic Hydrocarbons

One-Electron Oxidation of Aromatic Hydrocarbons: Radical Cations

Discussion

References to Appendix IV

Index




Details

No. of pages:
618
Language:
English
Copyright:
© Academic Press 1985
Published:
Imprint:
Academic Press
eBook ISBN:
9781483216010

About the Author

Yin-Tak Woo

David Y. Lai

Joseph C. Arcos