Chemical Induction of Cancer: Structural Bases and Biological Mechanisms, Volume IIIB: Aliphatic and Polyhalogenated Carcinogens covers environmentally and occupationally significant carcinogens of industrial origins.
The book discusses the structure-activity relationships, metabolism, and environmental significance of the halogenated linear alkanes and alkenes and the halogenated cycloalkanes; and cycloalkene pesticides, biphenyls, and related aromatics. The text also describes the structure-activity relationships, metabolism, and environmental significance of the halogenated phenoxy acids, aromatic ethers, dibenzofurans, and dibenzo-p-dioxins; and ethylene glycol, diethylene glycol, dioxane, and related compounds. The structure-activity relationships, metabolism, and environmental significance of phenols and phenolic compounds; nitroalkanes and nitroalkenes; and acetamide, dimethylcarbamyl chloride, and related compounds thiocarbonyl compounds are also encompassed. The book further tackles the structure-activity relationships, metabolism, and environmental significance if fatty acids, detergents, and other surfactants with oncogenic potential. The text then looks into the effect of chemical reactivity, molecular geometry, and metabolism on carcinogenic activity.
Chemists, geneticists, and those involved in cancer research will find the book invaluable.
General Plan Preface Acknowledgments Part III (Continued) Structure-Activity Relationships of Chemical Carcinogens. Effect of Reactivity, Molecular Geometry, and Metabolism on Carcinogenic Activity5. Structure-Activity Relationships 5.2.Nonconjugated Organic Compounds Updating Notes Notes Added after Completion of Section 188.8.131.52 Notes Added after Completion of Section 184.108.40.206 Notes Added after Completion of Section 220.127.116.11 Notes Added after Completion of Section 18.104.22.168 Notes Added after Completion of Section 22.214.171.124 Notes Added after Completion of Section 126.96.36.199 Notes Added after Completion of Section 188.8.131.52 Notes Added after Completion of Section 184.108.40.206 Appendix I. Novel Types of Carcinogens Carbazole Anthanthrene Benzene Furylfuramide (Furfurylamide; AF-2) Niridazole 4-Nitropyridine N-Oxide Quinoline and Its Derivatives Quinoxaline 1,4-Dioxide Benzoyl Chloride and Other Acylating Agents Acetone Oxime (Acetoxime) Pronamide ZAMI 1305 Hycanthone 1,3-Butadiene Aniline and Azobenzene 4-Aminoazobenzene References to Appendix I Appendix II. Update to Vol. I: New Developments in Short-Term Tests for Carcinogenicity: Genetic Toxicology Testing Introduction Application of Genotoxicity Data to Human Health Effects Development of Genetic Toxicology Bioassays Application of Short-Term Bioassays to the Assessment of Human Cancer and Mutation Risk Concluding Remarks References to Appendix II Appendix III. Update to Vol. I: New Perspectives in Cancer Research Data Search: Modern Computer-Based Information Systems Introduction Computer Databases Useful for Cancer Research
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- © Academic Press 1985
- 25th April 1985
- Academic Press
- eBook ISBN: