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Chemical Induction of Cancer: Structural Bases and Biological Mechanisms, Volume IIIB: Aliphatic and Polyhalogenated Carcinogens covers environmentally and occupationally significant carcinogens of industrial origins.
The book discusses the structure-activity relationships, metabolism, and environmental significance of the halogenated linear alkanes and alkenes and the halogenated cycloalkanes; and cycloalkene pesticides, biphenyls, and related aromatics. The text also describes the structure-activity relationships, metabolism, and environmental significance of the halogenated phenoxy acids, aromatic ethers, dibenzofurans, and dibenzo-p-dioxins; and ethylene glycol, diethylene glycol, dioxane, and related compounds. The structure-activity relationships, metabolism, and environmental significance of phenols and phenolic compounds; nitroalkanes and nitroalkenes; and acetamide, dimethylcarbamyl chloride, and related compounds thiocarbonyl compounds are also encompassed. The book further tackles the structure-activity relationships, metabolism, and environmental significance if fatty acids, detergents, and other surfactants with oncogenic potential. The text then looks into the effect of chemical reactivity, molecular geometry, and metabolism on carcinogenic activity.
Chemists, geneticists, and those involved in cancer research will find the book invaluable.
Part III (Continued) Structure-Activity Relationships of Chemical Carcinogens. Effect of Reactivity, Molecular Geometry, and Metabolism on Carcinogenic Activity
5. Structure-Activity Relationships
5.2.Nonconjugated Organic Compounds
Notes Added after Completion of Section 220.127.116.11
Notes Added after Completion of Section 18.104.22.168
Notes Added after Completion of Section 22.214.171.124
Notes Added after Completion of Section 126.96.36.199
Notes Added after Completion of Section 188.8.131.52
Notes Added after Completion of Section 184.108.40.206
Notes Added after Completion of Section 220.127.116.11
Notes Added after Completion of Section 18.104.22.168
Appendix I. Novel Types of Carcinogens
Furylfuramide (Furfurylamide; AF-2)
Quinoline and Its Derivatives
Benzoyl Chloride and Other Acylating Agents
Acetone Oxime (Acetoxime)
Aniline and Azobenzene
References to Appendix I
Appendix II. Update to Vol. I: New Developments in Short-Term Tests for Carcinogenicity: Genetic Toxicology Testing
Application of Genotoxicity Data to Human Health Effects
Development of Genetic Toxicology Bioassays
Application of Short-Term Bioassays to the Assessment of Human Cancer and Mutation Risk
References to Appendix II
Appendix III. Update to Vol. I: New Perspectives in Cancer Research Data Search: Modern Computer-Based Information Systems
Computer Databases Useful for Cancer Research
Automatic Selective Dissemination of Information
Special Cancer Databases
Other Databases of Interest for Cancer Research
Special Publications That Provide Useful Information to Cancer Researchers
References to Appendix III
Appendix IV. Update to Vol. IIA: Metabolic Activation by One-Electron and Two-Electron Oxidation in Aromatic Hydrocarbon Carcinogenesis
Enzymology of One-Electron and Two-Electron Oxidation
Two-Electron Oxidation or Monooxygenation of Aromatic Hydrocarbons
One-Electron Oxidation of Aromatic Hydrocarbons: Radical Cations
References to Appendix IV
- No. of pages:
- © Academic Press 1985
- 25th April 1985
- Academic Press
- eBook ISBN:
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