1st Edition - January 23, 2019

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  • Editor: Gerald Litwack
  • eBook ISBN: 9780128177839
  • Hardcover ISBN: 9780128177822

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Aldosterone, Volume 109, the latest release in the Vitamins and Hormones series first published in 1943, covers the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms, with this release focusing on topics relating to Aldosterone Research, Aldosterone and Micrornas, the Evolution of the Mineralocorticoid Receptor, Aldosterone and Kidney Micrornas, Adipocyte Mineralocorticoid Receptor, Regulation of Aldosterone Secretion, Leptin and Aldosterone, Cell- and Ligand-Specific Interactions in Mineralocorticoid Receptor Signaling, Primary Aldosteronism, Present and Future, Aldosterone-Producing Adenomas, Overexpression of the Mineralocorticoid Receptor, Aldosterone and Myocardial Pathology, and much more.

Key Features

  • Focuses on the newest aspects of hormone action in connection with diseases, with this update focusing on aldosterone
  • Lays the groundwork for the focus of new chemotherapeutic targets
  • Represents reviews on emerging areas in hormone action, cellular regulators and signaling pathways


Intense basic science to the molecular and physiological aspects of a particular disease state. Basic scientists and clinicians interested in the focus of a given volume

Table of Contents

  • Preface
    Gerald Litwack
    1. Regulation of Aldosterone Signaling by MicroRNAs
    Michael B. Butterworth and Diego Alvarez de la Rosa
    2. Evolution of the Mineralocorticoid Receptor
    Michael E. Baker and Yoshinao Katsu
    3. Adipocyte Mineralocorticoid Receptor
    Marco Infante, Andrea Armani, Vincenzo Marzolla, Andrea Fabbri and Massimiliano Caprio
    4. Regulation of Aldosterone Secretion
    Scott M. MacKenzie, Josie van Kralingen and Eleanor Davies
    5. Leptin and Aldosterone
    Jessica L. Faulkner and Eric J. Belin de Chantemèle
    6. Mechanisms of Mineralocorticoid Receptor Signaling
    Peter J. Fuller, Jun Yang and Morag J. Young
    7. Aldosterone Research: 65 Years, and Counting
    John W. Funder
    8. Primary Aldosteronism: Present and Future
    John Funder
    9. Aldosterone-Producing Adenomas
    Per Hellman, Peyman Björklund and Tobias Åkerström
    10. Brain Mineralocorticoid Receptors and Resilience to Stress
    Sofia Kanatsou, Marian Joels and Harm Krugers
    11. Aldosterone and Myocardial Pathology
    Alessandro Cannavo, Andrea Elia, Daniela Liccardo, Giuseppe Rengo and Walter J. Koch
    12. Paracrine Regulation of Aldosterone Secretion in Physiological and Pathophysiological Conditions
    Hervé Lefebvre, Céline Duparc, Alexandre Naccache, Antoine-Guy Lopez, Mireille Castanet and Estelle Louiset
    13. Nongenomic Effects of Aldosterone
    Anastasia S. Mihailidou, Andreas G. Tzakos and Anthony W. Ashton
    14. Mineralocorticoid Receptor Antagonists
    Anneli Nordqvist and Kenneth L. Granberg
    15. Aldosterone and Ion Channels
    William C. Valinsky, Rhian M. Touyz and Alvin Shrier
    16. Inhibitors of Aldosterone Synthase
    Steven M. Weldon and Nicholas F. Brown
    17. Aldosterone, the Mineralocorticoid Receptor and Mechanisms of Cardiovascular Disease
    Morag J. Young and Gail K. Adler

Product details

  • No. of pages: 449
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: January 23, 2019
  • Imprint: Academic Press
  • eBook ISBN: 9780128177839
  • Hardcover ISBN: 9780128177822

About the Series Editor

Gerald Litwack

Gerald Litwack
Dr. Gerald Litwack obtained M.S. and PhD degrees from the University of Wisconsin Department of Biochemistry and remained there for a brief time as a Lecturer on Enzymes. Then he entered the Biochemical Institute of the Sorbonne as a Fellow of the National Foundation for Infantile Paralysis. He next moved to Rutgers University as an Assistant Professor of Biochemistry and later as Associate Professor of biochemistry at the University of Pennsylvania Graduate School of Medicine. After four years he moved to the Temple University School of Medicine as Professor of Biochemistry and Deputy Director of the Fels Institute for Cancer Research and Molecular Biology, soon after, becoming the Laura H. Carnell Professor. Subsequently he was appointed chair of Biochemistry and Molecular Pharmacology at the Jefferson Medical College as well as Vice Dean for Research and Deputy Director of the Jefferson Cancer Institute and Director of the Institute for Apoptosis. Following the move of his family, he became a Visiting Scholar at the Department of Biological Chemistry of the Geffen School of Medicine at UCLA and then became the Founding Chair of the Department of Basic Sciences at the Geisinger Commonwealth School of Medicine, becoming Professor of Molecular and Cellular Medicine and Associate Director of the Institute for Regenerative Medicine at the Texas A&M Health Science Center as his final position. During his career he was a visiting scientist at the University of California, San Francisco and Berkeley, Courtauld Institute of Biochemistry, London and the Wistar Institute. He was appointed Emeritus Professor and/or Chair at Rutgers University, Thomas Jefferson University and the Geisinger Commonwealth School of Medicine. He has published more than 300 scientific papers, authored three textbooks and edited more than sixty-five books. Currently he lives with his family and continues his authorship and editorial work in Los Angeles.

Affiliations and Expertise

Emeritus Professor and/or Chair at Rutgers University, Thomas Jefferson University and the Geisinger Commonwealth School of Medicine, USA; Toluca Lake, North Hollywood, California, USA

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