Aldosterone - 1st Edition - ISBN: 9780080133683, 9781483159973


1st Edition

International Series of Monographs in Pure and Applied Biology

Authors: Edith Gláz Paul Vecsei
Editors: P. N. Campbell S. P. Datta L. L. Engel
eBook ISBN: 9781483159973
Imprint: Pergamon
Published Date: 1st January 1971
Page Count: 628
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Aldosterone provides a comprehensive and detailed review of the problems that have arisen in the course of research on aldosterone, particularly with respect to their physiological roles and clinical implications. Topics covered include the biosynthesis, transport, and metabolism of aldosterone, as well as its biological activity and control of its secretion. A variety of pathological conditions, both acute and chronic, associated with aldosterone is also discussed. This volume is comprised of 10 chapters and opens with a historical background on aldosterone research, with emphasis on the discovery of the function of the adrenal cortex. The next chapter summarizes the methods suitable for the evaluation of aldosterone activity, from investigations of mineral metabolism to determination of the concentration of aldosterone or aldosterone metabolites; estimation of secretion of aldosterone; and examination of aldosterone metabolism. Subsequent chapters explore the biosynthesis, transport, and metabolism of aldosterone; secretion of aldosterone, factors affecting secretion, and how it can be controlled; pathological conditions caused by either an increase or a decrease in aldosterone secretion, including aldosteronism, Conn's syndrome, hypoaldosteronism, and hypomineralocorticism. The therapeutic uses of aldosterone are discussed in the last chapter. This book will appeal to biologists and biochemists.

Table of Contents

Preface Part I Chapter I Historical Survey Chapter II Methodology Electrolyte and Water Metabolism The Level of Biologically Active Aldosterone Aldosterone Levels in Blood Plasma Concentration of Aldosterone in the Urine Estimation of Aldosterone Secretion Estimation of the Metabolism of Aldosterone Description of Methods for the Estimation of Aldosterone Contemporary Methods in Aldosterone Research Chapter III Biosynthesis, Transport and Metabolism of Aldosterone Chapter IV Biological Activity Chapter V Control of Secretion of Aldosterone Control of Secretion of Aldosterone Factors Affecting the Secretion Rate Mechanisms Controlling Aldosterone Secretion Regulatory Mechanisms Affecting the Biosynthesis of Aldosterone Feedback Mechanism in the Control of Aldosterone Secretion Diurnal Variations in the Secretion of Aldosterone Part II (Edith Glaz) Chapter VI Aldosteronism. Mineralocorticism "Primary" Aldosteronism. Conn's Syndrome Symptoms and Signs of Primary Aldosteronism Case Report Diagnosis of Primary Aldosteronism Differential Diagnosis of Conn's Syndrome Therapy Chapter VII "Secondary" Aldosteronism
Acute Secondary Aldosteronisms Stress Chronic Secondary Aldosteronisms Bartter's Syndrome Hypertensive Diseases Renal Diseases: The Nephrotic Syndrome Congestive Heart Failure Diseases of the Liver: Cirrhosis Pregnancy Idiopathic Oedema Miscellaneous Aldosteronism "Mixed" Forms of Aldosteronism Cushing's Syndrome Congenital Adrenal Hyperplasia Chapter IX Hypoaldosteronism. Hypomineralocorticism Selecti


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© Pergamon 1971
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About the Author

Edith Gláz

Paul Vecsei

About the Editor

P. N. Campbell

S. P. Datta

L. L. Engel

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