Alcoholic Hepatitis, An Issue of Clinics in Liver Disease

1st Edition, Volume 25-3 - July 7, 2021
Editor: Paul Y. Kwo
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 8 9 7 0 0 - 6
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 8 9 7 0 1 - 3

In this issue of Clinics in Liver Disease, Guest Editor Paul Kwo brings his considerable expertise to the topic of Alcoholic Hepatitis. Top experts in the field cover key topics… Read more

Alcoholic Hepatitis, An Issue of Clinics in Liver Disease

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In this issue of Clinics in Liver Disease, Guest Editor Paul Kwo brings his considerable expertise to the topic of Alcoholic Hepatitis. Top experts in the field cover key topics such as the Epidemiology of Alcoholic Hepatitis, Nutrition in Those with Alcoholic Hepatitis, Current therapies for alcoholic hepatitis, Selection Criteria for Liver Transplantation for Acute Alcoholic Hepatitis, and more.

Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
Epidemiology of Alcohol-Associated Liver Disease
Key points
Introduction
Alcohol consumption and alcohol-associated liver disease
Spectrum of alcohol-associated liver disease
Epidemiology of alcohol-associated liver disease
Factors influencing the natural history and progression of alcohol-associated liver disease
Perspectives and conclusion
Current and Future Biomarkers in Alcoholic Hepatitis
Key points
Introduction
The ideal biomarker
Clinical settings where alcoholic hepatitis biomarkers are needed
Severe alcoholic hepatitis and acute-on-chronic liver failure
Fibrosis
Current algorithms to prognosticate in alcoholic hepatitis
Future biomarkers in alcoholic hepatitis
Summary
Clinics care points
Genetic and Environmental Susceptibility to Alcoholic Hepatitis
Key points
Introduction
Steatohepatitis and alcoholic hepatitis: Nomenclature
Natural history of alcohol-related liver disease
Risk factors for the development of alcohol-related cirrhosis
Genetic risk factors
Specific risk factors for the clinical syndrome of alcoholic hepatitis
Summary
Clinics care points
Disclosure
Moderate Alcoholic Hepatitis
Key points
Introduction
Natural history
Diagnosis
Management options
Summary
Clinics Care Points
Disclosure
Malnutrition and Alcohol-Associated Hepatitis
Key points
Introduction
Discussion
Summary
funding
Clinics Care Points
Diagnosis of Alcohol-Associated Hepatitis: When Is Liver Biopsy Required?
Key points
Introduction
Diagnosis of asymptomatic alcohol-associated hepatitis
Diagnosis of symptomatic alcohol-associated hepatitis
Liver biopsy in predicting prognosis of alcohol-associated hepatitis
Noninvasive biomarkers in diagnosis and prognosis of alcohol-associated hepatitis
Summary
Clinics care points
Assessing the Severity and Prognosis of Alcoholic Hepatitis
Key points
Introduction
Natural history
Established models/scoring systems
Other related clinical factors
Other prognostic and potentially more novel tools
Summary
Clinics care points
Current Therapies for Alcohol-Associated Hepatitis
Key points
Introduction
Corticosteroid therapy
Antitumor necrosis factor targets
N-acetylcysteine
Granulocyte colony-stimulating factor
Summary
Clinics care points
Emerging Therapies for Alcoholic Hepatitis
Key points
Introduction
Agents modulating the gut-liver axis
Agents with anti-inflammatory activity
Agents with antioxidant activity
Agents that modulate regenerative pathways
Summary
Clinics care points
Disclosure
Current Trends in Liver Transplantation for Alcoholic Hepatitis
Key points
Introduction
Historical justification to perform liver transplantation in alcohol-related liver disease
Evolution of alcohol-related liver disease as the leading indication for liver transplantation
Diagnostic criteria for alcoholic hepatitis
Evidence-based rationale for liver transplantation in alcoholic hepatitis
Controversies in duration of sobriety prior to liver transplantation for alcoholic hepatitis
Stepwise evaluation for liver transplantation in alcoholic hepatitis
Outcomes for liver transplantation in alcoholic hepatitis from Europe
Outcomes for liver transplantation in alcoholic hepatitis from United States
Summary
Clinics care points
Disclosure
Selection Criteria for Liver Transplantation for Acute Alcohol-Associated Hepatitis
Key points
Background
Ethical considerations
International experience with liver transplantation for alcohol-associated hepatitis
Medical selection criteria
Psychosocial selection criteria
Payer coverage
Summary
Clinics care points
Approaching Alcohol Use Disorder After Liver Transplantation for Acute Alcoholic Hepatitis
Key points
Introduction
Diagnosis and pretransplant medical management of alcoholic hepatitis
The role for early liver transplantation in alcoholic hepatitis and available clinical experience
Optimizing transplant outcomes in early liver transplantation for severe alcoholic hepatitis
Summary
Clinics care points