Alcohol and Aldehyde Metabolizing Systems

Alcohol and Aldehyde Metabolizing Systems

Intermediary Metabolism and Neurochemistry

1st Edition - January 1, 1977

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  • Editors: Ronald G. Thurman, John R. Williamson, Henry R. Drott
  • eBook ISBN: 9781483265384

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Alcohol and Aldehyde Metabolizing Systems, Volume III: Intermediary Metabolism and Neurochemistry contains some of the papers presented at the Second International Symposium on Alcohol and Aldehyde Metabolizing Systems, held at the University of Pennsylvania in October 1976. Experts in the field from a wide variety of backgrounds tackled the problems of alcohol and aldehyde metabolism, discussed research findings, and examined controversial issues such as the effects of alcohol and aldehydes on intermediary metabolism. Comprised of 64 chapters, this volume begins with an analysis of the non-equilibrium behavior of biochemical systems, followed by a discussion on the configurational specificity of glycolytic enzymes. The reader is methodically introduced to redox compartmentation and the measurement of intracellular compartmentation of metabolites in rat liver; effect of chronic alcohol and oxygen tension on the development of hepatic necrosis in rats; and actions of ethanol metabolism on fatty acid synthesis in the liver. Subsequent chapters focus on regional metabolic rate in the central nervous system as related to function; effects of tetrahydroisoquinoline derivatives of catecholamines and aldehydes on tyrosine hydroxylase; and lowering of blood acetaldehyde levels as a therapeutic approach to alcoholism. This book will be of value to practitioners and researchers from a variety of disciplines, including neurochemistry, biochemistry, physiology, cell biology, and pharmacology.

Table of Contents

  • List Of Participants


    Biochemical Compartmentation

    Nonequilibrium Behavior of Biochemical Systems

    Configurational Specificity of Glycolytic Enzymes

    Interaction of the ADP, ATP Transport with the System of Oxidative Phosphorylation

    Measurement of Intracellular Compartmentation of Metabolites in Rat Liver

    Redox Compartmentation: A Survey with Emphasis on Current Problems

    Possible Metabolic Zonation of Liver Parenchyma into Glucogenic and Glycolytic Hepatocytes

    Intermediary Metabolism

    Oxygen Uptake by Isolated Liver Cells from Ethanol-Fed Rats

    Effect of Chronic Alcohol and Oxygen Tension on the Development of Hepatic Necrosis in Rats

    Mechanism of Increased Hepatic Oxygen Uptake due to Ethanol

    The Effect of Ethanol on the Metabolism of [1-14C] Palmitate in Perfused Rat Liver

    Specific and Nonspecific Effects of Long-Term Administration of Ethanol on Hepatic Fatty Acid Synthesis and Its Role in the Development of Fatty Liver

    Effect of Ethanol on the Number of Tritium Atoms Incorporated from Tritiated Water into Hepatic Cholesterol during Its Biosynthesis from Mevalonate in Vivo

    Actions of Ethanol Metabolism on Fatty Acid Synthesis in the Liver

    Reduced Protein Synthesis in Isolated Rat Liver Parenchymal Cells due to Ethanol

    New in Vitro Thiamin Reactions Catalyzed by Rat Tissues

    Effect of Ethanol on Folate Deficiency in Rats

    Liver Prolyl Hydroxylase as an Indicator of Fibrogenesis in Alcoholic Cirrhosis

    Isotope Effect in Metabolism of 3H-Ethanol

    Oxidation of Reducing Equivalents during Ethanol Metabolism. Studies with 1-3H-Ethanol

    The Oxidation of Acetaldehyde by Rat Hepatic, Non-Hepatic and Tumor Mitochondria

    Ethanol-Oxidizing Enzymes in Transplantable Hepatocellular Carcinoms

    Compartmentation of Metabolites between Cytosol and Mitochondria in Rat Liver Cells

    Thermodynamic Aspects of Hydrogen Transfer via the Malate-Aspartate Shuttle under Conditions of Steady-State Phosphorylation and Reduction Potentials

    Effect of Acute Murine Hepatitis (MHV-A-59) on Ethanol Oxidation in Vivo

    Changes of Microsomal Steroid-4en-5α-Reductase Activity in Rat Liver by Alcohol Feeding. Effect of Phenobarbital-Treatment and Feeding Standard or Low Protein Diets

    Acetaldehyde Oxidation by Isolated Hepatic Aldehyde Dehydrogenase, Mitochondria and Parenchymal Cells, and by Perfused Intact Liver of the Rat

    Hepatic Acetaldehyde Metabolism during Ethanol Oxidation

    Stimulation of Hepatic Acetaldehyde Uptake in Perfused Rat Liver by Fructose

    Mechanism of the Fructose Effect on Ethanol Oxidation

    Effectiveness of Fructose in the Management of Alcohol Withdrawal Syndrome in Man

    In Vivo Metabolism of Ethanol at High and Low Concentrations

    The Role of Alcohol Dehydrogenase in Governing Rates of Ethanol Metabolism in Rats

    Studies on the Role of the ADH Pathway in Increased Ethanol Elimination after Chronic Alcohol Intake in the Rat and Man

    Factors Altering the Rate of Alcohol Metabolism in Hepatocytes

    Regulation of Alcohol Oxidation in Man: Inhibition (Fasting) and Stimulation (Phenobarbital Treatment or Chronic Alcohol Consumption) Is Equalized by Fructose Infusion

    Inverse Distribution of Glycolytic and Gluconeogenic Enzymes in the Liver Lobule

    Pharmacokinetics and Hydroxylation of Phenazone in Chronic Alcoholism

    Urinary Electrolytes and Diuresis in Hangover

    Metabolism of Pyrazole in the Rat

    Effects of Dietary Ethanol and Disulfiram Metabolites in Weanling Rats

    Determination of Disulfiram and Metabolites in Plasma and Tissue

    Interactions between Ethanol and 4-Methylpyrazole in the Rat

    Neurochemistry and Neuropharmacology

    Control of Metabolic Systems in Brain

    Regional Metabolic Rate in Central Nervous System as Related to Function

    Distribution and Regulation of Cyclic Nucleotides Levels in Brain, in Vivo

    The Effect of Bilateral Ischemia and Recirculation on Energy Reserves and Cyclic Nucleotides in the Cerebral Cortex of Gerbils

    Regional Distribution of Amino Acid Neurotransmitters and Transmitter Candidates

    Acetaldehyde and Withdrawal

    Studies on the Effects of Tetrahydroisoquinoline Derivatives of Catecholamines and Aldehydes on Tyrosine Hydroxylase

    Acetaldehyde Occurrence in Cerebrospinal Fluid and Its Dependence on the Blood Level and on Aldehyde Dehydrogenase Inhibitors

    Lowering of Blood Acetaldehyde Levels as a Therapeutic Approach to Alcoholism

    New Strains of Rats with Alcohol Preference and Non-Preference

    Alcohol Drinking Induced in the Rat after Chronic Injections of Tetrahydropapaveroline (THP), Salsolinol or Noreleagnine in the Brain

    Ethanol and Acetaldehyde Metabolism during Ethanol Consumption

    Ethanol, Not Acetaldehyde, Determines Severity of Withdrawal Seizures in Mice

    Changes of Brain Cyclic Nucleotides Induced by Ethanol Administration and Withdrawal

    Kinetics of Alterations in Brain Cyclic AMP Levels during Ethanol Treatment and Withdrawal

    Effect of p-Chlorophenylalanine on the Acquisition, Maintenance and Loss of Tolerance to Ethanol

    Quantitative Histochemical Study of Metabolic Effects of Ethanol

    Ethanol Induced Changes in the Properties of Brain Ribosomes

    Alcohol Metabolism of Inbred Strains of Rats with Alcohol Preference and Nonpreference

    Selective Breeding of Rats for Differences in Reactivity to Alcohol: An Approach to an Animal Model of Alcoholism. IV. Some Behavioral and Chemical Measures

    Adoption Studies of Alcoholism

    Learned Preferences as an Approach to the Development of an Animal Model of Alcoholism

    Ethanol as a Teratogen


Product details

  • No. of pages: 698
  • Language: English
  • Copyright: © Academic Press 1977
  • Published: January 1, 1977
  • Imprint: Academic Press
  • eBook ISBN: 9781483265384

About the Editors

Ronald G. Thurman

John R. Williamson

Henry R. Drott

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