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Alcohol and Aldehyde Metabolizing Systems - 1st Edition - ISBN: 9780126914023, 9781483265469

Alcohol and Aldehyde Metabolizing Systems

1st Edition

Enzymology and Subcellular Organelles

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Editors: Ronald G. Thurman John R. Williamson Henry R. Drott
eBook ISBN: 9781483265469
Imprint: Academic Press
Published Date: 1st January 1977
Page Count: 472
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Alcohol and Aldehyde Metabolizing Systems, Volume II: Enzymology and Subcellular Organelles contains some of the papers presented at the Second International Symposium on Alcohol and Aldehyde Metabolizing Systems, held at the University of Pennsylvania in October 1976. Experts in the field from a wide variety of backgrounds tackled the problems of alcohol and aldehyde metabolism, discussed research findings, and examined controversial issues ranging from the molecular structure of enzymes to the clinical actions of alcohol in humans.

Comprised of 43 chapters, this volume begins by comparing the enzymatically catalyzed oxidation of glyceraldehyde-3-phosphate and lactate, followed by an analysis of liver alcohol dehydrogenase and its mechanism of action. The reader is methodically introduced to the kinetics and mechanism of activated liver alcohol dehydrogenase; structural and functional changes in different alcohol dehydrogenases during evolution; and localization and properties of aldehyde reductase. Subsequent chapters deal with the correlation between the activity of acetaldehyde dehydrogenase and the structure of mitochondria; the distribution of subcellular organelles; and peroxisomes and microsomes.

This book will be of value to practitioners and researchers from a variety of disciplines, including biochemistry, physiology, cell biology, and pharmacology.

Table of Contents

List of Participants


Enzyme Structure and Mechanism

A Comparison of the Enzymatically Catalyzed Oxidation of Glyceraldehyde-3-Phosphate and Lactate

Mechanism of Action of Liver Alcohol Dehydrogenase

Extrapolation of Mechanism Studies on Glyceraldehyde-3-Phosphate Dehydrogenase to the Treatment of Avian Muscular Dystrophy

Alcohol and Aldehyde Dehydrogenase

Kinetics and Mechanism of Activated Liver Alcohol Dehydrogenase

Solvent Isotope Effects in the Yeast Alcohol Dehydrogenase Reaction

Kinetics of Native and Chemically Activated Human Liver Alcohol Dehydrogenase

Substrate Specificity and the Hydrophobic Site of Liver Alcohol Dehydrogenase (L-ADH)

Properties of Horse Liver Alcohol Dehydrogenase SS

Room and Low Temperature Spectral Identification of the Cobalt Bindings Sites in Liver Alcohol Dehydrogenase

Heterogeneity in the Rapidly Exchanging Metals of Horse Liver Alcohol Dehydrogenase

Magnetic Resonance Studies of the Interactions of Imidazole and Other Ligands with Cobalt Substituted Alcohol Dehydrogenase from Liver

Water Proton Relaxation and Spectral Studies of Alcohol Dehydrogenase Partially Substituted with Cobalt

Interaction and Activities of NAD+ and NAD+ Analogs with Four Dehydrogenases

Modification of Tryptophan in Liver Alcohol Dehydrogenase

Structural and Functional Changes in Different Alcohol Dehydrogenases during Evolution

Metal Ion Effectors of Horse Liver Aldehyde Dehydrogenases

Interaction of Disulfiram with Horse Liver Aldehyde Dehydrogenase

Intracellular Location of 3,4-Dihydroxyphenylacetaldehyde and Acetaldehyde Oxidation in Rat Liver

Localization and Properties of Aldehyde Reductase

Human Liver Aldehyde Dehydrogenase

Inhibition of Rat-Liver Aldehyde Dehydrogenases in Vitro and in Vivo by Disulfiram, Cyanamide, and the Alcohol-Sensitizing Compound Coprine

Correlation between the Activity of Acetaldehyde Dehydrogenase and the Structure of Mitochondria

Induction of Cytosolic Aldehyde Dehydrogenase Isozymes: Influence on Acetaldehyde Metabolism

Subcellular Organelles and their Distribution

The Plastic and Fluid Nature of the Mitochondrial Energy Transducing Membrane

Peroxide Generation in Mitochondria and Utilization by Catalase

Metabolism of HjOj and Fatty Acids by Rat Liver Peroxisomes: ImpHcations for Ethanol Detoxification

Some Effects of Aging and Lipid-Lowering Drugs on Lipid Metabolism and the Hepatic Endoplasmic Reticulum

Peroxisomes and Microsomes

On the Question of Whether Cytochrome P-450 Catalyzes Ethanol Oxidation: Studies with Purified Forms of the Cytochrome from Rabbit Liver Microsomes

Evidence for the Direct Involvement of Hepatic Cytochrome P450 in Ethanol Metabolism

Advantages of Gas Chromatographic Determination of Acetaldehyde in Studies with Ethanol and a Reconstituted Enzyme System Containing Electrophoretically Homogenous Phenobarbital-Inducible Cytochrome P-450 from Rabbit Liver Microsomes

Reconstitution of the Hepatic Microsomal Ethanol Oxidizing System (MEOS) in Control Rats and After Ethanol Feeding

Microsomal Electron Transport Reactions: The Formation and Utilization of Hydrogen Peroxide as Related to Alcohol Metabolism

Studies of the Characterization of the Enzyme Components Participating in the Hepatic-Microsomal Oxidation of Aliphatic Alcohols

Quantitation of Pathways Responsible for NADPH-Dependent Methanol, Ethanol, and Butanol Oxidation by Hepatic Microsomes

Catalase and Alcohol Dehydrogenase-Mediated Oxidation of Ethanol in Hepatic Microsomes of Acatalasemic Mice

Analysis of Mitochondrial and Microsomal Cytochromes in Human Liver Biopsy

A Novel Route for the Metabolism of Ethanol: The Oxidation of Ethanol by Hydroxyl Free Radicals

Folate Deficiency and Methanol Poisoning in the Rat

The Monkey as a Model in Methanol Poisoning

Methanol Poisoning: Role of Formate Metabolism in the Monkey

Mitochondrial Injury in Experimental Chronic Alcoholism



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© Academic Press 1977
1st January 1977
Academic Press
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About the Editor

Ronald G. Thurman

John R. Williamson

Henry R. Drott

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