Alcohol and Abnormal Protein Biosynthesis

Preface

Acknowledgments

List of Contributors

Section One Introduction and Methods


1. Malnutrition and Alcoholism—An Overview


2. Available Techniques for the Study of Protein Synthesis


3. In Vitro Analysis of Hepatic Plasma Protein Synthesis

Section Two Protein Synthesis and Transport: Adaptation to Alcohol and Malnutrition


4. Regulation of Protein Synthesis in Relation to Amino Acid Supply—A Review


5. Metabolic Adaptations to Protein Deficiency


6. Effect of Ethanol on Intestinal Amino Acid Transport


7. Cellular Protein Transport

Section Three Skeletal and Cardiac Muscle Protein Metabolism


8. Cardiac Morphologic Changes Produced by Ethanol


9. The Action of Ethanol Upon the Contractility of Normal Ventricular Myocardium


10. Diet and Protein Metabolism in Skeletal Muscle


11. The Control of Protein Turnover in the Isolated Perfused Rat Heart


12. Metabolic Adaptation to Alcohol in the Heart


13. Stress and Myocardial Protein Synthesis: The Effect of Alcohol and Acetaldehyde

Section Four Hepatic Protein Synthesis—Reaction to Malnutrition and Alcohol


14. Morphologic Studies of Alcoholic Liver Injury


15. Metabolic Adaptation to Alcohol in the Liver and Transition to Tissue Injury, Including Cirrhosis


16. The Influence of Alcohol and Altered Nutrition on Albumin Synthesis


17. The Effect of Ethanol on Albumin and Fibrinogen Synthesis In Vivo and in Hepatocyte Suspensions


18. Hepatic Blood Flow and Protein Synthesis


19. The Nutritional Potential of Enterohepatically Recycled Urea Nitrogen in Man

Section Five Effects of Alcohol on Brain RNA Metabolism


20. Chronic Ethanol Ingestion by Rodents: Effects on Brain RNA


21. Cerebral Metabolic Abnormalities in Thiamine Deficiency

Section Six Alcohol Associated Cardiac and Hepatic Disease


22. Alcoholic Cardiovascular Disease


23. Alcoholic Liver Disease


24. Therapy of Alcoholic Liver Disease

Index