AID for Immunoglobulin Diversity - 1st Edition - ISBN: 9780123737069, 9780080545929

AID for Immunoglobulin Diversity, Volume 94

1st Edition

Editors: Frederick Alt
eBook ISBN: 9780080545929
Hardcover ISBN: 9780123737069
Imprint: Academic Press
Published Date: 5th June 2007
Page Count: 344
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Table of Contents

Discovery of Activation-Induced Cytidine Deaminase, the Engraver of Antibody Memory DNA Deamination in Immunity: Aid in the Context of Its Apobec Relatives The Role of Activation Induced Deaminase in Antibody Diversification and Chromosome Translocations Targeting of AID-mediated Sequence Diversification by cis-acting Determinants AID-initiated Purposeful Mutations in Immunoglobulin Genes Post-translational AID Regulation Beyond SHM and CSR: AID and Related Cytidine Deaminases in the Host Response to Viral Infection AID expression and tumorigenesis
Pathophysiology of B Cell Intrinsic Immunoglobulin Class Switch Recombination Deficiencies


Advances in Immunology, a long established and highly respected serial, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.


Immunologists and infectious disease specialists, cell biologists and hematologists


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© Academic Press 2007
Academic Press
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Ratings and Reviews

About the Editors

Frederick Alt Editor

Affiliations and Expertise

Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA