AGO-driven Non-Coding RNAs - 1st Edition - ISBN: 9780128156698

AGO-driven Non-Coding RNAs

1st Edition

Codes to Decode the Therapeutics of Diseases

Editors: Bibekanand Mallick
Paperback ISBN: 9780128156698
Imprint: Academic Press
Published Date: 1st March 2019
Page Count: 500
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Description

Great strides have been made to harness the potential of some classes of ncRNAs, especially microRNAs to translate them from bench to practice to improve health by early detection, prevention, cure, and therapeutics of diseases including cancer. AGO-driven Non-Coding RNAs introduces readers to the latest research in non-coding RNAs (ncRNAs) and Argonaute proteins. The book aims to provide an overview of updated concepts, genomic approaches, and research progress involved in utilizing non-coding RNAs, particularly two popular classes of small ncRNAs, microRNAs and PIWI-interacting RNAs, as well as their interacting proteins, AGO and PIWI, as biomarkers for diagnosis, prognosis, or therapeutic agents for treatment of diseases. The book also goes on to discuss the integration of high-throughput genomic technologies with molecular biology and bioinformatics which has revolutionized the fields of regulatory RNA research. For researchers, scientists, and medical professionals who want to learn more about ncRNAs, AGO-driven Non-Coding RNAs is a comprehensive resource that includes the latest research, integrative technologies, their regulation mechanisms, and their vital roles in early detection and treatment of complex diseases.

Key Features

  • Discusses recent discoveries on the involvement of Argonaute and PIWI proteins in normal biological processes and diseases
  • Covers major discoveries related to the fundamentals and applications of ncRNAs for diagnosis and therapeutics
  • Examines high-throughput technologies and other novel methods for detection of these ncRNAs and their targets

Readership

Researchers, biologists from other areas of biology, medical professionals and Bioinformaticists, postdoctoral fellows and graduate students in the field of molecular biology, genetics, and biomedical sciences

Table of Contents

1. Roles of microRNAs in neurodegeneration: lessons from Parkinson's disease models
Ilya A. Vinnikov
2. miRNAs shaping cellular reprogramming
Zhumur Ghosh
3. MicroRNAs in diagnosis and therapeutics
Dhafer Laouini, Fatma Guerfali and Chiraz Atri
4. microRNA therapeutics for Glioblastoma: Candidates and Targeting Strategies
Ritu Kulshreshtha
5. piRNAs in the pathophysiology of disease and potential clinical applications
Sambasivarao Damaraju
6. Rejuvenation of piRNAs in emergence of cancer hallmarks
Zhumur Ghosh
7. Two small non-Coding RNAs, Two different mechanisms: MicroRNAs and PIWI Interacting RNAs-From Origin to Diseases
Cagri Oner
8. Small RNA Machinery genes as novel Disease biomarker
Bibekanand Mallick
9. Role of miRNAs in cardiovascular diseases and their therapeutic implications
Santosh Kumar and Hemant Suryawanshi
10. Computational Methods for miRNA & piRNA in Gene Discovery & Functional Predictions
Chao Wu and Peter M. Clark
11. PiRNA-Cancer Connection: From Risk to Therapeutics
Yong Zhu
12. Emerging roles of miRNAs as a regulator in progression of lung cancer and their implications in its diagnosis and therapy
Bijesh K. Biswal
13. The role of microRNAs in bacterial infections
Joyoti Basu

Details

No. of pages:
500
Language:
English
Copyright:
© Academic Press 2019
Published:
Imprint:
Academic Press
Paperback ISBN:
9780128156698

About the Editor

Bibekanand Mallick

Dr. Bibekanand Mallick is Head of the Department of Life Science at the National Institute of Technology Rourkela. He received his M.Tech. degree in biotechnology from Indian Institute of Technology, Kharagpur, one of the premiere Institutes in India, and his PhD at the Indian Association for the Cultivation of Science, Kolkata, He has published in journals like NAR, RNA, BBRC, DNA Research, and JBSD as well as co-authored a book, Bioinformatics: Principles and Applications. He was invited to the Rockefeller University as a Visiting Fellow and was a research affiliate at the New York State Department of Health. He received the prestigious William J. Whelan Fellowship Award for presenting his work at Miami Winter Symposium in 2008. His research career is mainly focused on regulatory RNA biology and bioinformatics. His current research in the RNAi and Functional Genomics Laboratory focuses on the study of crosstalks or interference mediated by regulatory non-coding RNAs (rncRNAs), such as microRNA (miRNA), piwi-interacting RNA (piRNA), long non-coding RNA (lncRNA), competing endogenous RNA. (ceRNA), and many more.

Affiliations and Expertise

Head of the Department, Department of Life Science, National Institute of Technology Rourkela

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