1st Edition

Oxidative Stress and Dietary Antioxidants

Editors: Victor Preedy
Hardcover ISBN: 9780124059337
eBook ISBN: 9780124055230
Imprint: Academic Press
Published Date: 5th March 2014
Page Count: 316
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Aging: Oxidative Stress and Dietary Antioxidants bridges the trans-disciplinary divide and covers in a single volume the science of oxidative stress in aging and the potentially therapeutic use of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial, and oxidative stress is a single component of this.

Gerontologists, geriatricians, nutritionists, and dieticians are separated by divergent skills and professional disciplines that need to be bridged in order to advance preventative as well as treatment strategies. While gerontologists and geriatricians may study the underlying processes of aging, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of gerontology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of aging.

Key Features

  • Nutritionists can apply information related to mitochondrial oxidative stress in one disease to diet-related strategies in another unrelated disease
  • Dietitians can prescribe new foods or diets containing anti-oxidants for conditions resistant to conventional pharmacological treatments
  • Dietitians, after learning about the basic biology of oxidative stress, will be able to suggest new treatments to their multidisciplinary teams
  • Nutritionists and dietitians will gain an understanding of cell signaling and be able to suggest new preventative or therapeutic strategies with anti-oxidant rich foods


Nutritionists, dieticians, gerontologists, and aging researchers

Table of Contents

  • Contributors
  • Preface
  • Section 1 Oxidative Stress and Aging
  • Chapter 1. Oxidative Stress and Frailty: A Closer Look at the Origin of a Human Aging Phenotype
  • Introduction
  • Oxidative Stress and Aging
  • Frailty
  • Oxidative Stress and Frailty
  • Unanswered Questions
  • Conclusion and Future Perspectives
  • Summary Points
  • Chapter 2. Skin Aging and Oxidative Stress
  • Introduction
  • The Structure of Human Skin
  • Measuring Skin Aging
  • Cellular Correlates of Skin Aging
  • Oxidative Stress and Intrinsic Skin Aging
  • Environmental Exposures Associated With Skin Aging
  • Photoaging
  • Conclusions
  • Summary Points
  • Chapter 3. Cardiovascular Disease in Aging and the Role of Oxidative Stress
  • Introduction
  • Physiology of the Aging Cardiovascular System
  • The Molecular Basis of Oxidative Stress as Applied to the Cardiovascular System
  • Longevity Genes and the Longevity Network
  • Other Genes and Pathways in Oxidative Stress and Age-Related Cardiovascular Diseases
  • Summary Points
  • Chapter 4. Oxidative Stress, Aging and Mitochondrial Dysfunction in Liver Pathology
  • Introduction
  • Evidence for Age-Associated Morphologic, Structural and Functional Changes in the Liver
  • Evidence for Age-Associated Loss of Mitochondrial Bioenergetics in Liver
  • Oxidative Stress and Antioxidant Responses in Liver Aging
  • Oxidative Damage to the Nuclear and Mitochondrial Genomes in Liver Aging
  • Mitochondrial Dysfunction and Liver-Associated Disease
  • Conclusion
  • Summary Points
  • Chapter 5. Arthritis as a Disease of Aging and Changes in Antioxidant Status
  • Introduction
  • The Concept of Oxygen Toxicity and Free Radicals
  • Oxidative Stress in Arthritis
  • Summary Poin


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About the Editor

Victor Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC is a senior member of King's College London. He is also Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine. Professor Preedy has longstanding academic interests in substance misuse especially in relation to health and well being. He is a member of the Editorial Board of Drug and Alcohol Dependence and a founding member of the Editorial Board of Addiction Biology. In his career Professor Preedy was Reader at the Addictive Behaviour Centre at The University of Roehampton, and also Reader at the School of Pharmacy (now part of University College London; UCL). Professor Preedy is Editor of the influential works The Handbook Of Alcohol Related Pathology, The Neuropathology of Drug Addictions and Substance Misuse and The Handbook of Cannabis and Related Pathologies (all published by Academic Press-Elsevier). Professor Preedy graduated in 1974 with an Honours Degree in Biology and Physiology with Pharmacology. He gained his University of London PhD in 1981. In 1992, he received his Membership of the Royal College of Pathologists and in 1993 he gained his second doctoral degree (DSc). Professor Preedy was elected as a Fellow of the Institute of Biology in 1995 and also as a Fellow to the Royal College of Pathologists in 2000. He was then elected as a Fellow of the Royal Society for the Promotion of Health (2004) and The Royal Institute of Public Health and Hygiene (2004). In 2009, Professor Preedy became a Fellow of the Royal Society for Public Health and in 2012 a Fellow of the Royal Society of Chemistry. To his credit, Professor Preedy has published over 600 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.

Affiliations and Expertise

Department of Dietetics, King's College London, UK